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Joshua D. Hoffman
University of California, San Francisco
35Publications
8H-index
452Citations
Publications 35
Newest
#1Nima C. Emami (UCSF: University of California, San Francisco)H-Index: 3
#2Linda Kachuri (UCSF: University of California, San Francisco)H-Index: 8
Last.Elad Ziv (UCSF: University of California, San Francisco)H-Index: 51
view all 12 authors...
#1Nima C. Emami (UCSF: University of California, San Francisco)H-Index: 3
#2Linda Kachuri (UCSF: University of California, San Francisco)H-Index: 8
Last.Elad Ziv (UCSF: University of California, San Francisco)H-Index: 51
view all 12 authors...
Here we train cis-regulatory models of prostate tissue gene expression and impute expression transcriptome-wide for 233,955 European ancestry men (14,616 prostate cancer (PrCa) cases, 219,339 controls) from two large cohorts. Among 12,014 genes evaluated in the UK Biobank, we identify 38 associated with PrCa, many replicating in the Kaiser Permanente RPGEH. We report the association of elevated TMPRSS2 expression with increased PrCa risk (independent of a previously-reported risk variant) and wi...
#1Joshua D. Hoffman (UCSF: University of California, San Francisco)H-Index: 8
#2Laura Fejerman (UCSF: University of California, San Francisco)H-Index: 16
Last.Jeffrey N. Weitzel (City of Hope National Medical Center)H-Index: 49
view all 22 authors...
Background Breast cancer is a partially heritable trait and genome-wide association studies (GWAS) have identified over 180 common genetic variants associated with breast cancer. We have previously performed breast cancer GWAS in Latinas and identified a strongly protective single nucleotide polymorphism (SNP) at 6q25, with the protective minor allele originating from indigenous American ancestry. Here we report on fine mapping of the 6q25 locus in an expanded sample of Latinas.
#1Sara R. Rashkin (UCSF: University of California, San Francisco)H-Index: 1
#2Rebecca E. Graff (UCSF: University of California, San Francisco)H-Index: 11
Last.Joshua D. Hoffman (UCSF: University of California, San Francisco)H-Index: 8
view all 19 authors...
Deciphering the shared genetic basis of distinct cancers has the potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts. However, no studies have investigated pan-cancer pleiotropy within single, well-defined populations. We undertook novel genome-wide association studies (GWAS) and comprehensive evaluations of heritability and pleiotropy across 18 cancer types in two large, population-based cohorts: the UK Biobank (413,870 European ancestry individu...
#1Nick Shrine (University of Leicester)H-Index: 15
#2Anna L. Guyatt (University of Leicester)H-Index: 5
Last.Phuwanat Sakornsakolpat (MU: Mahidol University)H-Index: 5
view all 109 authors...
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological ...
#1Ioanna TachmazidouH-Index: 20
Last.Julia Steinberg (Cancer Council New South Wales)H-Index: 8
view all 21 authors...
Osteoarthritis is the most common musculoskeletal disease and the leading cause of disability globally. Here, we performed a genome-wide association study for osteoarthritis (77,052 cases and 378,169 controls), analyzing four phenotypes: knee osteoarthritis, hip osteoarthritis, knee and/or hip osteoarthritis, and any osteoarthritis. We discovered 64 signals, 52 of them novel, more than doubling the number of established disease loci. Six signals fine-mapped to a single variant. We identified put...
#1Manuel A. Ferreira (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 44
#2Judith M. Vonk (UMCG: University Medical Center Groningen)H-Index: 50
Last.Yi Lu (KI: Karolinska Institutet)H-Index: 19
view all 22 authors...
Background A recent genome-wide association study (GWAS) identified 99 loci that contain genetic risk variants shared between asthma, hay fever, and eczema. Many more risk loci shared between these common allergic diseases remain to be discovered, which could point to new therapeutic opportunities. Objective We sought to identify novel risk loci shared between asthma, hay fever, and eczema by applying a gene-based test of association to results from a published GWAS that included data from 360,8...
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