Match!
Hong Seok Kang
Konkuk University
VirologyHepatitis BHepatitis B virusBiologyHepatocyte nuclear factors
13Publications
5H-index
79Citations
What is this?
Publications 14
Newest
#1Gu Choul Shin (Konkuk University)H-Index: 11
#2Sung Ung Moon (Sookmyung Women's University)
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 6 authors...
Source
#1Gu Choul Shin (Konkuk University)H-Index: 11
#2Sung Ung Moon (Sookmyung Women's University)
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 6 authors...
Unfolded protein response (UPR) is an adaptive mechanism that aims at restoring ER homeostasis under severe environmental stress. Malignant cells are resistant to environmental stress, which is largely due to an activated UPR. However, the molecular mechanisms by which different UPR branches are selectively controlled in tumor cells are not clearly understood. Here, we provide evidence that PRKCSH, previously known as glucosidase II beta subunit, functions as a regulator for selective activation...
Source
#1Eun Sook Park (Konkuk University)H-Index: 11
#2Ah Ram Lee (Konkuk University)H-Index: 5
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 26 authors...
Background & Aims Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Methods Two patients with viral breakthrough during treatment with TDF-containing regimens were prospectively enrolled. The gene encoding HBV reverse transcriptase was sequenced. ...
5 CitationsSource
#1Eun Sook Park (Konkuk University)H-Index: 11
#2Young-Ho Byun (Yonsei University)H-Index: 12
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 25 authors...
3 CitationsSource
#1Doo Hyun Kim (Konkuk University)H-Index: 7
#2Eun Sook Park (Konkuk University)H-Index: 11
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 17 authors...
Cytokines are involved in early host defense against pathogen infections. In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes. However, the molecular mechanisms and mediator molecules are largely unknown. Here we show that interleukin-32 (IL-32) is induced by TNF and IFN-γ in hepatocytes, and inhibits the replication of HBV by acting intracellularly to suppress HBV transcription an...
3 CitationsSource
#1Ah Ram Lee (Konkuk University)H-Index: 5
#2Keo Heun Lim (Konkuk University)H-Index: 1
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 15 authors...
1 CitationsSource
#1Doo Hyun KimH-Index: 7
#2Hong Seok KangH-Index: 5
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 12 authors...
1 CitationsSource
#1Keo Heun Lim (Konkuk University)H-Index: 1
#2Eun Sook Park (Konkuk University)H-Index: 11
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 23 authors...
Objective Interferons (IFNs) mediate direct antiviral activity. They play a crucial role in the early host immune response against viral infections. However, IFN therapy for HBV infection is less effective than for other viral infections. Design We explored the cellular targets of HBV in response to IFNs using proteome-wide screening. Results Using LC-MS/MS, we identified proteins downregulated and upregulated by IFN treatment in HBV X protein (HBx)-stable and control cells. We found several IFN...
18 CitationsSource
#1Gu Choul Shin (Konkuk University)H-Index: 11
#2Hong Seok Kang (Konkuk University)H-Index: 5
Last. Kyun-Hwan Kim (Konkuk University)H-Index: 22
view all 4 authors...
ABSTRACTDeath receptors of TNFSF10/TRAIL (tumor necrosis factor superfamily member 10) contribute to immune surveillance against virus-infected or transformed cells by promoting apoptosis. Many viruses evade antiviral immunity by modulating TNFSF10 receptor signaling, leading to persistent infection. Here, we report that hepatitis B virus (HBV) X protein (HBx) restricts TNFSF10 receptor signaling via macroautophagy/autophagy-mediated degradation of TNFRSF10B/DR5, a TNFSF10 death receptor, and th...
15 CitationsSource
#1Doo Hyun KimH-Index: 7
#2Hong Seok KangH-Index: 5
Last. Kyun-Hwan KimH-Index: 22
view all 3 authors...
Approximately 350 million people are estimated to be persistently infected with hepatitis B virus (HBV) worldwide. HBV maintains persistent infection by employing covalently closed circular DNA (cccDNA), a template for all HBV RNAs. Chronic hepatitis B (CHB) patients are currently treated with nucleos(t)ide analogs such as lamivudine, adefovir, entecavir, and tenofovir. However, these treatments rarely cure CHB because they are unable to inhibit cccDNA transcription and inhibit only a late stage...
9 CitationsSource
12