Elizabeth R. Mann
University of Manchester
ImmunologyDendritic cellMedicineBiologyImmune system
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Publications 75
#1Nicholas A. Scott (University of Manchester)H-Index: 3
#2Elizabeth R. Mann (University of Manchester)H-Index: 16
Mucosal tissues contain distinct microbial communities that differ drastically depending on the barrier site, and as such, mucosal immune responses have evolved to be tailored specifically for their location. Whether protective or regulatory immune responses against invading pathogens or the commensal microbiota occur is controlled by local mononuclear phagocytes (MNPs). Comprising macrophages and dendritic cells (DCs), the functions of these cells are highly dependent on the local environment. ...
3 CitationsSource
#1María Martínez-López (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 8
#2Salvador Iborra (Complutense University of Madrid)H-Index: 21
Last. David Sancho (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 41
view all 23 authors...
Summary Production of interleukin-17 (IL-17) and IL-22 by T helper 17 (Th17) cells and group 3 innate lymphoid cells (ILC3s) in response to the gut microbiota ensures maintenance of intestinal barrier function. Here, we examined the mechanisms whereby the immune system detects microbiota in the steady state. A Syk-kinase-coupled signaling pathway in dendritic cells (DCs) was critical for commensal-dependent production of IL-17 and IL-22 by CD4+ T cells. The Syk-coupled C-type lectin receptor Min...
9 CitationsSource
#1Aoife Kelly (MAHSC: Manchester Academic Health Science Centre)H-Index: 5
#2Sezin Gunaltay (MAHSC: Manchester Academic Health Science Centre)H-Index: 1
Last. Mark A. TravisH-Index: 22
view all 10 authors...
10 CitationsSource
#1Nicholas A. Scott (University of Manchester)H-Index: 1
#2Anna Andrusaite (Glas.: University of Glasgow)H-Index: 2
Last. Elizabeth R. Mann (Glas.: University of Glasgow)H-Index: 16
view all 25 authors...
Macrophages in the healthy intestine are highly specialized and usually respond to the gut microbiota without provoking an inflammatory response. A breakdown in this tolerance leads to inflammatory bowel disease (IBD), but the mechanisms by which intestinal macrophages normally become conditioned to promote microbial tolerance are unclear. Strong epidemiological evidence linking disruption of the gut microbiota by antibiotic use early in life to IBD indicates an important role for the gut microb...
22 CitationsSource
#1John van Tuyn (Glas.: University of Glasgow)H-Index: 18
#2Farah Jaber-Hijazi (Glas.: University of Glasgow)H-Index: 5
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
view all 14 authors...
On acquisition of an oncogenic mutation, primary human and mouse cells can enter oncogene-induced senescence (OIS). OIS is characterized by a stable proliferation arrest and secretion of proinflammatory cytokines and chemokines, the senescence-associated secretory phenotype. Proliferation arrest and the senescence-associated secretory phenotype collaborate to enact tumor suppression, the former by blocking cell proliferation and the latter by recruiting immune cells to clear damaged cells. Howev...
7 CitationsSource
#1Ho Al-Hassi (University of Wolverhampton)
#2Gh Lee (University of Southampton)
Last. Stella C. Knight (Imperial College London)H-Index: 53
view all 11 authors...
Introduction Colorectal cancer (CRC) is a major cause of mortality. Dendritic cells (DC) promote tumour immunity or tolerance dictated by tissue microenvironment. Proximal colon (right-sided) CRC has lower incidence but poorer prognosis than distal colon (left-sided) CRC. This may be due to immunological differences between the proximal and distal colon. However, cellular and molecular studies on these differences especially in CRC are scarce. We aimed to characterise the immune activity in both...
#1Elizabeth R. Mann (Imperial College London)H-Index: 16
#2David Bernardo (Imperial College London)H-Index: 20
Last. Stella C. Knight (Imperial College London)H-Index: 53
view all 16 authors...
Objective Dendritic cells (DC) mediate intestinal immune tolerance. Despite striking differences between the colon and the ileum both in function and bacterial load, few studies distinguish between properties of immune cells in these compartments. Furthermore, information of gut DC in humans is scarce. We aimed to characterise human colonic versus ileal DC. Design Human DC from paired colonic and ileal samples were characterised by flow cytometry, electron microscopy or used to stimulate T cell ...
31 CitationsSource
#1David Bernardo (Imperial College London)H-Index: 20
#2Lydia Durant (Imperial College London)H-Index: 2
Last. Stella C. Knight (Imperial College London)H-Index: 53
view all 30 authors...
Background & Aims Most knowledge about gastrointestinal (GI)-tract dendritic cells (DC) relies on murine studies where CD103+ DC specialize in generating immune tolerance with the functionality of CD11b+/− subsets being unclear. Information about human GI-DC is scarce, especially regarding regional specifications. Here, we characterized human DC properties throughout the human colon.
15 CitationsSource
#1Romina Bertinat (Austral University of Chile)H-Index: 4
#2Pamela Silva (Austral University of Chile)H-Index: 4
Last. Alejandro J. Yáñez (Austral University of Chile)H-Index: 3
view all 6 authors...
Diabetic nephropathy (DN) is characterized by interstitial inflammation and fibrosis, which is the result of chronic accumulation of extracellular matrix produced by activated fibroblasts in the renal tubulointerstitium. Renal proximal tubular epithelial cells (PTECs), through the process of epithelial-to-mesenchymal transition (EMT), are the source of fibroblasts within the interstitial space, and loss of E-cadherin has shown to be one of the earliest steps in this event. Here, we studied the e...
4 CitationsSource