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Robert Wolk
Pfizer
EndocrinologyCardiologyObstructive sleep apneaDiabetes mellitusMedicine
59Publications
32H-index
4,014Citations
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Publications 58
Newest
#1Robert Wolk (Pfizer)H-Index: 32
#2Marnie Bertolet (University of Pittsburgh)H-Index: 17
Last. Virend K. Somers (Mayo Clinic)H-Index: 100
view all 11 authors...
Abstract Objective To evaluate the cardiovascular (CV) prognostic value of adipokines in a large prospective cohort of patients participating in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial. Patients and Methods The effects of the adipokine levels at baseline and change from baseline on the composite outcome (CV death, myocardial infarction, and stroke) were analyzed using unadjusted and fully adjusted Cox models in 2330 patients with type 2 diabetes and coronary arter...
6 CitationsSource
#1Robert Wolk (Pfizer)H-Index: 32
#2Marnie Bertolet (University of Pittsburgh)H-Index: 17
Last. Virend K. SomersH-Index: 100
view all 11 authors...
AimsTo determine the effects of insulin sensitization (IS) and insulin provision (IP) treatment strategies on adipokines associated with cardiovascular disease in patients with type 2 diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial (BARI 2D).Methods and resultsChanges in adipokine levels were compared in patients with type 2 diabetes mellitus and coronary artery disease randomized to IS (n = 1037) versus IP (n = 1019) treat...
7 CitationsSource
#1Michal Hoffmann (Gdańsk Medical University)H-Index: 10
#2Prachi Singh (Mayo Clinic)H-Index: 17
Last. Virend K. Somers (Mayo Clinic)H-Index: 100
view all 5 authors...
Objective Dual specificity phosphatase 1 (DUSP1) inhibits mitogen activated protein kinase activity, and is activated by several stimuli such as sustained hypoxia, oxidative stress, and hormones. However, the effect of intermittent hypoxia is not known. The aim of this study was to evaluate the role of intermittent hypoxia on DUSP1 expression, and to validate its role in a human model of intermittent hypoxia, as seen in obstructive sleep apnea (OSA). OSA is characterized by recurrent episodes of...
12 CitationsSource
Source
#1Burton E. Sobel (UVM: University of Vermont)H-Index: 96
#2Regina M. Hardison (UVM: University of Vermont)H-Index: 17
Last. Robert L. Frye (UVM: University of Vermont)H-Index: 58
view all 11 authors...
Background—Effects were compared in patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial of 2 mechanistically different strategies for treatment of hyperglycemia, insulin-sensitizing and insulin-providing strategies, on biomarker profiles reflecting the balance between fibrinolysis and thrombosis and the intensity of inflammation implicated in diabetic vasculopathy. Methods and Results—A total of 2368 patients with type 2 diabetes mellitus and clinically ...
49 CitationsSource
#1Paola A. Lanfranchi (Mayo Clinic)H-Index: 7
#2Michael J. Ackerman (Mayo Clinic)H-Index: 112
Last. Virend K. Somers (Mayo Clinic)H-Index: 100
view all 8 authors...
Background Patients with congenital long QT syndrome (LQTS) type 2 (LQT2) may develop arrhythmias during emotional stress, acoustic stimuli, or sleep. Women with LQT2 are more susceptible to fatal arrhythmias than are men. Objective The purpose of this study was to examine the effects of sleep on RR and QT intervals in patients with LQT1, in those with LQT2, and in controls and to test the hypothesis that there is a gene-specific effect of sleep on the QT interval in LQT2 that may be especially ...
11 CitationsSource
#1Anna Svatikova (Mayo Clinic)H-Index: 19
#2Lyle J. Olson (Mayo Clinic)H-Index: 33
Last. Virend K. Somers (Mayo Clinic)H-Index: 100
view all 7 authors...
OBSTRUCTIVE SLEEP APNEA (OSA) HAS BEEN ASSOCIATED WITH INCREASED RISK FOR CARDIOVASCULAR MORBIDITY INCLUDING HYPERTENSION. HOWEVER, disease mechanisms linking OSA to hypertension have not been completely elucidated.1–3 High sympathetic activity in normotensive patients with OSA, both during sleep and wakefulness, may promote hypertension4,5 as may increased oxidative stress,6–9 inflammation10–12 and endothelial dysfunction.13,14 The renin-angiotensin-aldosterone system (RAS) plays a central role...
37 CitationsSource
ILLUMINATE, the phase 3 morbidity and mortality trial of the cholesteryl ester transfer protein (CETP) inhibitor, torcetrapib, plus atorvastatin terminated in 2006. The underlying morbidity and mortality cause remains undetermined. In addition to lipoprotein changes, off-target increases in blood pressure (BP), sodium, bicarbonate, and aldosterone and potassium decreases were described. We report nonclinical and clinical studies using torcetrapib and a closely related CETP inhibitor, CP-532,623,...
19 CitationsSource
#1Abel Romero-Corral (Mayo Clinic)H-Index: 32
#2Justo Sierra-Johnson (KI: Karolinska Institutet)H-Index: 21
Last. Virend K. Somers (Mayo Clinic)H-Index: 100
view all 10 authors...
Leptin may be a key regulator of C-reactive protein (CRP) levels, which in turn, is a marker of systemic inflammation. Both leptin and CRP are predictors of cardiovascular disease (CVD). High leptin levels are independently associated with CVD even after adjustment for CRP; elevated CRP levels are not associated with CVD after adjustment for leptin. However, subjects with increased leptin and CRP are at the highest risk for CVD.
57 CitationsSource
#1Prachi SinghH-Index: 17
#2Michal Hoffmann (Gdańsk Medical University)H-Index: 10
Last. Virend K. SomersH-Index: 100
view all 5 authors...
Objective— There is increasing evidence of an association between leptin and increased cardiovascular risk. Higher leptin levels are associated with increased levels of C-reactive protein (CRP), which itself elicits proatherogenic effects in the vascular endothelium. We tested the hypothesis that leptin induces CRP expression in human coronary artery endothelial cells (HCAECs). Methods and Results— We confirmed the presence of both long and short isoforms of the leptin receptor in cultured HCAEC...
98 CitationsSource
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