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Peter R. Williamson
National Institutes of Health
ImmunologyCryptococcus neoformansVirulenceBiologyMicrobiology
110Publications
38H-index
11kCitations
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Publications 114
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#1Yoon-Dong Park (NIH: National Institutes of Health)H-Index: 13
#2Shu Hui Chen (NIH: National Institutes of Health)H-Index: 2
Last. Peter R. Williamson (NIH: National Institutes of Health)H-Index: 38
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The endosomal sorting complex required for transport (ESCRT) plays a crucial role in the transportation and degradation of proteins. We determined that Vps27, a key protein of the ESCRT-0 complex, is required for the transport of the virulence factor laccase to the cell wall in Cryptococcus neoformans Laccase activity was perturbed as well as melanin production in vps27Delta strains. In the absence of VPS27 there was an accumulation of multi-vesicular bodies with vacuolar fragmentation and mista...
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#1Kieren A. Marr (Johns Hopkins University)H-Index: 82
#2Seher AnjumH-Index: 1
Last. Peter R. WilliamsonH-Index: 38
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#1Katherine Traino (NIH: National Institutes of Health)H-Index: 1
#2Joseph Snow (NIH: National Institutes of Health)H-Index: 15
Last. Peter R. Williamson (NIH: National Institutes of Health)H-Index: 38
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Twenty-seven previously healthy (of 36 consecutive eligible patients), HIV-negative cryptococcal meningoencephalitis (CM) patients underwent comprehensive neuropsychological evaluation during the late post-treatment period (1.3–4 years post diagnosis), assessing attention, language, learning, memory, visuospatial, executive function, information processing, psychomotor functioning, as well as mood symptoms. Seven of eight domains (all except attention) showed increased percentages of CM patients...
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Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) that leads to the death of neurons and oligodendrocytes, which cannot be measured in living subjects. Physiological cellular death, otherwise known as apoptosis, progresses through a series of stages which culminates in the discharge of cellular contents into vesicles known as apoptotic bodies (ABs) or apoptosomes. These ABs can be detected in bodily fluids as Annexin-V-positive vesicles of 0.5-4.0 µm in size....
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#1Seher Anjum (NIH: National Institutes of Health)H-Index: 1
#2Peter R. WilliamsonH-Index: 38
Last. Peter Kosa (NIH: National Institutes of Health)H-Index: 12
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#1Yu-Shan Cheng (NIH: National Institutes of Health)H-Index: 1
#2Peter R. Williamson (NIH: National Institutes of Health)H-Index: 38
Last. Wei Zheng (NIH: National Institutes of Health)H-Index: 105
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Infections from multidrug resistant (MDR) pathogens and emerging viruses present challenges for effective clinical treatments. Drug repurposing and combination screens may provide therapies at a fraction of the time and cost of traditional methods of drug development. Synergistic combinations of two or three known compounds can increase therapeutic efficacy and reduce concentrations required for individual drugs, in turn, reducing the risk of drug toxicity. Using libraries of approved drugs, tra...
2 CitationsSource
#1Davis P. Argersinger (NIH: National Institutes of Health)H-Index: 2
#2Vitaliy P. Natkha (TTUHSC: Texas Tech University Health Sciences Center)
Last. John D. Heiss (NIH: National Institutes of Health)H-Index: 32
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#1Seher Anjum (NIH: National Institutes of Health)H-Index: 1
#2Peter R. Williamson (NIH: National Institutes of Health)H-Index: 38
Purpose of Review To perform an extensive review of recent literature and provide an update on the current epidemiology, clinical features, and management of cryptococcal disease with a focus on the differences between patients depending on their immune status.
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#1Kelly A. KingH-Index: 16
#2Ghedak AnsariH-Index: 1
Last. Peter R. WilliamsonH-Index: 38
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1 CitationsSource
#1Ruying LuH-Index: 2
#2Christopher Hollingsworth (NIH: National Institutes of Health)
Last. Peter R. Williamson (NIH: National Institutes of Health)H-Index: 38
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ABSTRACT Cryptococcus neoformans is an encapsulated yeast responsible for approximately a quarter of a million deaths worldwide annually despite therapy, and upwards of 11% of HIV/AIDS-related deaths, rivaling the impact of tuberculosis and malaria. However, the most effective antifungal agent, amphotericin B, requires intravenous delivery and has significant renal and hematopoietic toxicity, making it difficult to utilize, especially in resource-limited settings. The present studies describe a ...
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