Peter R. Williamson
National Institutes of Health
Publications 106
#1Yu-Shan Cheng (NIH: National Institutes of Health)
#2Peter R. Williamson (NIH: National Institutes of Health)H-Index: 36
Last.Wei Zheng (NIH: National Institutes of Health)H-Index: 110
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Infections from multidrug resistant (MDR) pathogens and emerging viruses present challenges for effective clinical treatments. Drug repurposing and combination screens may provide therapies at a fraction of the time and cost of traditional methods of drug development. Synergistic combinations of two or three known compounds can increase therapeutic efficacy and reduce concentrations required for individual drugs, in turn, reducing the risk of drug toxicity. Using libraries of approved drugs, tra...
#1Seher Anjum (NIH: National Institutes of Health)
#2Peter R. Williamson (NIH: National Institutes of Health)H-Index: 36
Purpose of Review To perform an extensive review of recent literature and provide an update on the current epidemiology, clinical features, and management of cryptococcal disease with a focus on the differences between patients depending on their immune status.
#1Davis P Argersinger (NIH: National Institutes of Health)H-Index: 2
#2Vitaliy P. Natkha (TTUHSC: Texas Tech University Health Sciences Center)
Last.John D. Heiss (NIH: National Institutes of Health)H-Index: 30
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#1Ruying LuH-Index: 2
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ABSTRACT Cryptococcus neoformans is an encapsulated yeast responsible for approximately a quarter of a million deaths worldwide annually despite therapy, and upwards of 11% of HIV/AIDS-related deaths, rivaling the impact of tuberculosis and malaria. However, the most effective antifungal agent, amphotericin B, requires intravenous delivery and has significant renal and hematopoietic toxicity, making it difficult to utilize, especially in resource-limited settings. The present studies describe a ...
#1Nathan C. Bahr (KU: University of Kansas)H-Index: 12
#2Anil A. Panackal (NIH: National Institutes of Health)H-Index: 8
Last.Kieren A. Marr (Johns Hopkins University)H-Index: 80
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#1Damián Gatica (UM: University of Michigan)H-Index: 9
#2Guowu Hu (NIH: National Institutes of Health)H-Index: 4
Last.Daniel J. Klionsky (UM: University of Michigan)H-Index: 106
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Summary Macroautophagy/autophagy is a key catabolic recycling pathway that requires fine-tuned regulation to prevent pathologies and preserve homeostasis. Here, we report a new post-transcriptional pathway regulating autophagy involving the Pat1-Lsm (Lsm1 to Lsm7) mRNA-binding complex. Under nitrogen-starvation conditions, Pat1-Lsm binds a specific subset of autophagy-related ( ATG ) transcripts and prevents their 3′ to 5′ degradation by the exosome complex, leading to ATG mRNA stabilization and...