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Clifton Bogardus
National Institutes of Health
271Publications
75H-index
25.3kCitations
Publications 273
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Abstract The Pima Indians of the Gila River Indian Community in Arizona have participated in a long-range study of type 2 diabetes mellitus since 1965 and have been the subject of HLA typing and population studies since the early days of serological assays. These data have been in numerous HLA workshops and conferences and have been the source of at least five novel alleles at the classical HLA loci. In recent time nearly the entire study group was subject to next generation sequencing by whole ...
1 CitationsSource
The ability to switch fuels for oxidation in response to changes in macronutrient composition of diet (metabolic flexibility) may be informative of the individual susceptibility to weight gain. Seventy-nine healthy, weight-stable participants underwent 24-h assessments of energy expenditure and respiratory quotient (RQ) in a whole-room calorimeter during energy balance (EBL; 50% carbohydrate, 30% fat) and then during 24-h fasting and three 200% overfeeding diets in a crossover design. Metabolic ...
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#1Robert L. HansonH-Index: 72
Last.William C. KnowlerH-Index: 90
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#1Joon HaH-Index: 8
#2Stephanie T. ChungH-Index: 11
Last.Arthur ShermanH-Index: 46
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#1Samantha E. DayH-Index: 4
#2Yunhua L. MullerH-Index: 15
Last.Leslie J. BaierH-Index: 36
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American Indians suffer from a high prevalence of obesity. Although their obesity is typically polygenic in nature, we are systematically analyzing known monogenic obesity genes in a population-based sample of Pima Indians. Previously, we have reported that 3% of this population carries functional mutations in MC4R. The goal of the current study is to determine whether variation in any of the 21 known BBS genes also contribute to obesity in this population. Analysis of whole exome sequence data ...
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#1Yunhua L. MullerH-Index: 15
#2Samantha E. DayH-Index: 4
Last.Leslie J. BaierH-Index: 36
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#2Paolo PiaggiH-Index: 26
Last.Leslie J. BaierH-Index: 36
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Identification of high-impact loss-of-function variants for common disease is challenging because these variants are typically rare and thus statistical power is low when sample sizes are limited. In this study, we utilized whole-exome variant detection, variant prediction programs, tissue expression data, and case-control analysis to identify potentially highly penetrant obesity-susceptibility variants for prioritization for functional testing. Whole-exome sequencing was performed on DNA sample...
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#1Yunhua L. MullerH-Index: 15
#2Robert L. HansonH-Index: 72
Last.Leslie J. BaierH-Index: 36
view all 12 authors...
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#1Karyne L. Vinales (NIH: National Institutes of Health)H-Index: 4
#2Brittany Begaye (NIH: National Institutes of Health)H-Index: 1
Last.Paolo Piaggi (NIH: National Institutes of Health)H-Index: 26
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Fibroblast growth factor 21 (FGF21) regulates energy expenditure (EE) and influences weight change during low-protein overfeeding in rodent models. The change in EE after a low-protein overfeeding diet is a predictor of weight change in humans and a feature of the “thrifty” metabolic phenotype. However, there are no studies showing an association between circulating FGF21 and diet-related EE in humans. We assessed the changes in plasma FGF21 concentrations after 24 h of seven dietary interventio...
10 CitationsSource
#1Takafumi Ando (Japan Society for the Promotion of Science)H-Index: 6
#2Paolo Piaggi (NIH: National Institutes of Health)H-Index: 26
Last.Jonathan Krakoff (NIH: National Institutes of Health)H-Index: 37
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Abstract Background/Objectives Energy expenditure measured under sedentary conditions predicts weight change but evidence that directly measured VO2max is associated with weight change is lacking. The aim of this study was to determine the associations of VO2max with measures of predominantly sedentary 24-h thermogenesis, and subsequent weight change. Subjects/Methods Three hundred fifty-seven individuals (162 females; 27 Blacks, 72 Caucasians, and 258 American Indians) had measures of body comp...
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