Match!
Mohammad Razuanul Hoque
Tohoku University
6Publications
3H-index
135Citations
Publications 6
Newest
#1Mohammad Razuanul Hoque (Tohoku University)H-Index: 3
#2Toru Ishizuka (Tohoku University)H-Index: 17
Last.Hiromu Yawo (Tohoku University)H-Index: 35
view all 8 authors...
With the progress of optogenetics, the activities of genetically identified neurons can be optically silenced to determine whether the neurons in question are necessary for the network performance of the behavioral expression. This logical induction is expected to be improved by the application of the Na+ pump rhodopsins (NaRs), which hyperpolarize the membrane potential with negligible influence on the ionic/pH balance. Here, we made several chimeric NaRs between two NaRs, KR2 and IaNaR from Kr...
7 CitationsSource
#1S. Watanabe (Tohoku University)H-Index: 5
#2Toru Ishizuka (Tohoku University)H-Index: 17
Last.Hiromu Yawo (Tohoku University)H-Index: 35
view all 6 authors...
The five glutamate (E) residues of transmembrane (TM)-2 of channelrhodopsin (CrChR)-2 are conserved among several members of the ChR family. A point mutation of one of them, E97, to a nonpolar alanine (E97A) reduced the photocurrent amplitude without influencing other photocurrent properties. The charge at this position is also the determinant of the Gd3+-dependent block of the channel. It has thus been suggested that E97 interacts with hydrated cations to facilitate their permeation and that th...
3 CitationsSource
#1Shoko HososhimaH-Index: 4
#2Hideya YuasaH-Index: 21
Last.Hiromu YawoH-Index: 35
view all 9 authors...
Non-invasive remote control technologies designed to manipulate neural functions in the brain have been long-awaited for advancing a comprehensive and quantitative understanding of the neuronal network in the brain as well as for the therapy of neurological disorders such as Parkinson’s disease. Using optogenetics, target neurons have been genetically engineered to express light-sensitive proteins such as channelrhodopsin (ChR)-21, one of the algal photoreceptor proteins, and controlled to becom...
45 CitationsSource
#1Hideaki E. KatoH-Index: 16
#2Keiichi InoueH-Index: 21
Last.Osamu NurekiH-Index: 56
view all 23 authors...
Known microbial rhodopsins were classified into two groups, either outward proton pumps or inward chloride pumps, until the recent discovery of a light-driven Na+-pumping rhodopsin from the marine bacterium Krokinobacter eikastus. This novel protein, termed KR2, is attracting attention as a potential tool for use in optogenetics: its activation would change the sodium concentration of a targeted cell, not just the pH or chloride concentration. Now Osamu Nureki and colleagues have solved two X-ra...
80 CitationsSource
#1Hideaki E. KatoH-Index: 16
#2Keiichi InoueH-Index: 21
Last.Osamu NurekiH-Index: 56
view all 23 authors...
Source
#1Hideaki E. KatoH-Index: 16
#2Keiichi InoueH-Index: 21
Last.Osamu NurekiH-Index: 56
view all 23 authors...
Source
1