Shiv Pillai
Massachusetts Institute of Technology
Molecular biologyImmunologyB cellBiologyMicrobiology
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Publications 281
#1Vinay S. Mahajan (Ragon Institute of MGH, MIT and Harvard)H-Index: 20
#2Hamid Mattoo (Ragon Institute of MGH, MIT and Harvard)H-Index: 16
Last. Yesim Tuncay (Ragon Institute of MGH, MIT and Harvard)
view all 11 authors...
We show that DNA methylation is a layered process in B lymphocytes. An underlying foundational methylome is stably established during B lineage commitment and overlaid with a DNMT3A-maintained dynamic methylome which is sculpted in distinct ways in B1 and B2 B cells during B cell development. An engineered loss of DNMT3A after commitment to the B lineage unmasks a foundational methylome that is shared in both B1 and B2 sub-lineages. The dynamic methylome is comprised of novel enhancers whose met...
#1Blake Oberfeld (Harvard University)H-Index: 1
#2Aditya Achanta (Harvard University)
Last. Amy K. Barczak (Harvard University)H-Index: 18
view all 11 authors...
Abstract Coronavirus disease 2019 (COVID-19) is a novel respiratory illness caused by SARS-CoV-2. Viral entry is mediated through viral spike protein and host ACE2 enzyme interaction. Most cases are mild; severe disease often involves cytokine storm and organ failure. Therapeutics including antivirals, immunomodulators, and vaccines are in development. To view this SnapShot, open or download the PDF.
#1Marco Matucci-Cerinic (UniFI: University of Florence)H-Index: 71
#2Cosimo Bruni (UniFI: University of Florence)H-Index: 11
Last. David A. Fox (UM: University of Michigan)H-Index: 49
view all 20 authors...
Due to the frequent presence of interstitial lung disease and widespread use of immunosuppressive treatment, systemic sclerosis (SSc) patients may be considered at risk for a more severe disease course and higher mortality when they develop Severe Acute Respiratory Syndrome - Coronavirus - 2 (SARS-CoV-2) virus infection. Therefore, with World Scleroderma Foundation endorsement, experts from different specialties including rheumatology, virology and clinical immunology gathered virtually to answe...
#1Sandra Diaz (UCSD: University of California, San Diego)H-Index: 25
#2Yang Ji (UCSD: University of California, San Diego)
Last. Ajit Varki (UCSD: University of California, San Diego)H-Index: 108
view all 7 authors...
Purpose of reviewTo summarize recent advances in the understanding of the pathogenesis of IgG4-related disease.Recent findingsLimited data exist to explain genetic susceptibility to IgG4-related disease and the underlying triggers for this disease have not yet been identified. Cytotoxic CD4+ T cells
#1Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 14
#2Elena Rigamonti (UniSR: Vita-Salute San Raffaele University)H-Index: 8
Last. Shiv Pillai (Ragon Institute of MGH, MIT and Harvard)H-Index: 55
view all 19 authors...
Background IgG4-related disease (IgG4-RD) is a fibroinflammatory condition marked by rapid clinical improvement after selective depletion of B lymphocytes with rituximab. This feature suggests that B cells might participate in fibrogenesis and wound healing. Objective In the present work we aimed to demonstrate that B lymphocytes contribute directly to tissue fibrosis in patients with IgG4-RD. Methods Total circulating CD19+ B lymphocytes, naive B cells, memory B cells, or plasmablasts from pati...
#1Hang Liu (Ragon Institute of MGH, MIT and Harvard)
#1Hang Liu (PRC: China Medical University (PRC))H-Index: 1
Last. Shiv Pillai (Ragon Institute of MGH, MIT and Harvard)H-Index: 55
view all 7 authors...
OBJECTIVE: Four autoantigens have been described recently in IgG4-related disease (IgG4-RD): prohibitin, annexin A11, laminin 511-E8, and galectin-3. However, no external validation has been performed, and the possibility that some individuals break tolerance to more than 1 autoantigen has not been explored. We undertook this study to evaluate the relative frequencies of antibody responses against these autoantigens in order to explore the role of adaptive immune response in IgG4-RD. METHODS: Au...
#1Shiv Pillai (Ragon Institute of MGH, MIT and Harvard)H-Index: 55
#2Faisal Alsufyani (Ragon Institute of MGH, MIT and Harvard)H-Index: 1
The accumulation of B cells and tertiary lymphoid organs in metastatic melanoma patients receiving checkpoint blockade therapy was associated with long-term survival.
#1Takashi MaeharaH-Index: 16
#2Naoki Kaneko (MIT: Massachusetts Institute of Technology)H-Index: 1
Last. Musie GhebremichaelH-Index: 31
view all 16 authors...
Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly understood and lacks effective therapies. We undertook quantitative analyses of T cell infiltrates in the skin of thirty-five untreated patients with early diffuse SSc and here show that CD4+ cytotoxic T cells and CD8+ T cells contribute prominently to these infiltrates. We also observed an accumulation of apoptotic cells in SSc tissues, suggesting that recurring cell death may contribute to tissue damage and...
1 CitationsSource
#1Vinay S. MahajanH-Index: 20
#2Ezana DemissieH-Index: 2
Last. Shiv PillaiH-Index: 55
view all 11 authors...
The control of cytoskeletal dynamics by dedicator of cytokinesis 2 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicated in TCR signaling and T cell migration. Biallelic mutations in Dock2 have been identified in patients with a recessive form of combined immunodeficiency with defects in T, B, and NK cell activation. Surprisingly, we show in this study that certain immune functions of CD8(+) T cells are enhanced in the absence of DOCK2. Dock2-deficient mice have a pr...
1 CitationsSource