Shiv Pillai
Ragon Institute of MGH, MIT and Harvard
Publications 195
#1Ilka A Netravali (Ragon Institute of MGH, MIT and Harvard)
#2Annaiah Cariappa (Ragon Institute of MGH, MIT and Harvard)H-Index: 23
Last.Shiv Pillai (Ragon Institute of MGH, MIT and Harvard)H-Index: 45
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#1Takashi Maehara (Kyushu University)H-Index: 16
#2Shiv Pillai (Harvard University)H-Index: 45
Last.Seiji Nakamura (Kyushu University)H-Index: 33
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Abstract Immunoglobulin G4-related disease (IgG4-RD), recognized only recently as a single diagnostic entity, is a chronic inflammatory condition of unknown etiology. The diagnosis of IgG4-RD relies heavily on histopathological analysis and the correlation of histology findings with clinical, serological, and radiological data. CD4 + T and B cells, including IgG4-expressing plasmablasts, constitute the major inflammatory cell populations in IgG4-RD and are believed to cause organ damage and tiss...
#1Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 13
#2Elena Rigamonti (UniSR: Vita-Salute San Raffaele University)H-Index: 7
Last.Raffaella MilaniH-Index: 18
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Abstract Background IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition marked by rapid clinical improvement after selective depletion of B lymphocytes with rituximab. This feature suggests that B cells might participate in fibrogenesis and wound healing. Objective In the present work we aimed to demonstrate that B lymphocytes contribute directly to tissue fibrosis in IgG4-RD. Methods Total circulating CD19 + B-lymphocytes, naive B cells, memory B cells, or plasmablasts from IgG4-RD...
#1John H. Newman (Vandy: Vanderbilt University)H-Index: 56
#2Aaron C. Shaver (Vandy: Vanderbilt University)H-Index: 3
Last.William M. Stone (Ragon Institute of MGH, MIT and Harvard)
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#1Faisal Alsufyani (MIT: Massachusetts Institute of Technology)H-Index: 1
#2Faisal Alsufyani (MIT: Massachusetts Institute of Technology)
Last.Shiv Pillai (MIT: Massachusetts Institute of Technology)H-Index: 45
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T cells that target β-synuclein induce damage to the gray matter of the brain in multiple sclerosis and contribute to neurodegeneration.
#1Ezana Demissie (Ragon Institute of MGH, MIT and Harvard)H-Index: 1
#2Vinay S. Mahajan (Ragon Institute of MGH, MIT and Harvard)H-Index: 20
Last.Darrell J Irvine D J (MIT: Massachusetts Institute of Technology)H-Index: 61
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The control of cytoskeletal dynamics by Dedicator of cytokinesis 2 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicated in TCR signaling and T cell migration. Biallelic mutations in Dock2 have been identified in patients with a recessive form of combined immunodeficiency with defects in T, B and NK cell activation. Surprisingly, we show here that certain immune functions of CD8+ T cells are enhanced in the absence of DOCK2. Dock2-deficient mice have a pronounced exp...
#1Lei Wang (A&M: Texas A&M University)
#2Weining Cheng (NWAFU: Northwest A&F University)H-Index: 5
Last.Keyan Zhu-Salzman (A&M: Texas A&M University)H-Index: 29
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#1Vinay S. Mahajan (Brigham and Women's Hospital)H-Index: 20
#2Faisal Alsufyani (Ragon Institute of MGH, MIT and Harvard)H-Index: 1
Last.Shiv Pillai (Harvard University)H-Index: 45
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#1Cory A. Perugino (Harvard University)H-Index: 5
#2Sultan B. AlSalem (KSU: King Saud University)H-Index: 1
Last.Johannes Kreuzer (Harvard University)H-Index: 2
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Background The antigenic trigger that drives expansion of circulating plasmablasts and CD4 + cytotoxic T cells in patients with IgG 4 -related disease (IgG 4 -RD) is presently unknown. Objective We sought to sequence immunoglobulin genes from single-cell clones of dominantly expanded plasmablasts and generate recombinant human mAbs to identify relevant antigens in patients with IgG 4 -RD by using mass spectrometry. Methods Paired heavy and light chain cDNAs from dominant plasmablast clones were ...