Lara Menzies
University College London
PsychiatryDevelopmental psychologyPsychologyEndophenotypeAnxiety disorder
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Publications 22
1 CitationsSource
#1Anne-Lise Goddings (UCL: University College London)H-Index: 11
#2Lara Menzies (UCL: University College London)H-Index: 12
Last. Russell M. Viner (UCL: University College London)H-Index: 52
view all 6 authors...
During adolescence, risk-taking emerges as an important behaviour. One prominent theory proposes that this increased risk-taking results from a dissociation in the maturational timing of the brain regions involved in reward processing and cognitive control. It is hypothesised that the regions involved in reward processing, particularly the limbic system, mature relatively early in adolescence, in tandem with pubertal maturation. In contrast, the cognitive control regions of the brain, found prin...
#1Lara Menzies (UCL: University College London)H-Index: 12
#2Anne-Lise Goddings (UCL: University College London)H-Index: 11
Last. Russell M. Viner (UCL: University College London)H-Index: 52
view all 5 authors...
Neuroimaging studies demonstrate considerable changes in white matter volume and microstructure during adolescence. Most studies have focused on age-related effects, whilst puberty-related changes are not well understood. Using diffusion tensor imaging and tract-based spatial statistics, we investigated the effects of pubertal status on white matter mean diffusivity (MD) and fractional anisotropy (FA) in 61 males aged 12.7–16.0 years. Participants were grouped into early-mid puberty (≤Tanner Sta...
30 CitationsSource
#1Lara Menzies (UCL: University College London)H-Index: 12
#2Susan MinsonH-Index: 1
Last. C Fertleman (Whittington Hospital)H-Index: 2
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Objective To determine if demographic factors are associated with outcome in a multiple-choice, electronically marked paediatric postgraduate examination. Method Retrospective analysis of pass rates of UK trainees sitting Membership of the Royal College of Paediatrics and Child Health (MRCPCH) part 1B from 2007 to 2011. Data collected by the RCPCH from examination candidates were analysed to assess the effects of gender, age, and country and university of medical qualification on examination out...
2 CitationsSource
#1Lara Menzies (UCL: University College London)H-Index: 12
#2W Leith (Whittington Hospital)
End of life care is a challenging but vital aspect for children with life-threatening conditions, requiring parental discussion to plan appropriately. Parents express a need for open and honest information, delivered in a sensitive and timely manner. In adults, advanced care discussions (ACD) result in end of life care closer to patient preference, aligning care with patients’ wishes. However there is often patient dissatisfaction regarding the timing and content of ACD. A recent article in Pedi...
#1Samuel R. Chamberlain (University of Cambridge)H-Index: 42
#2Lara Menzies (University of Cambridge)H-Index: 12
#2Adam HampshireH-Index: 31
Last. Barbara J. SahakianH-Index: 133
view all 9 authors...
Context Trichotillomania is an Axis I disorder characterized by repetitive, pathological hair pulling. Objective To assess the integrity of white matter tracts in subjects with the disorder. Design Between-group comparison using permutation cluster analysis, with stringent correction for multiple comparisons. Setting Academic psychiatry department. Participants Eighteen volunteers meeting DSM-IV criteria for trichotillomania and 19 healthy control subjects. Main Outcome Measures Fractional aniso...
47 CitationsSource
#1Naomi A. Fineberg (University of Cambridge)H-Index: 44
#2Marc N. Potenza (Yale University)H-Index: 79
Last. Eric Hollander (Albert Einstein College of Medicine)H-Index: 88
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Failures in cortical control of fronto-striatal neural circuits may underpin impulsive and compulsive acts. In this narrative review, we explore these behaviors from the perspective of neural processes and consider how these behaviors and neural processes contribute to mental disorders such as obsessive–compulsive disorder (OCD), obsessive–compulsive personality disorder, and impulse-control disorders such as trichotillomania and pathological gambling. We present findings from a broad range of d...
377 CitationsSource
#2Adam HampshireH-Index: 31
Last. Barbara J. SahakianH-Index: 133
view all 9 authors...
Department of Psychiatry andMedical Research CouncilWellcome Trust Behaviouraland Clinical NeurosciencesInstitute (Drs Chamberlain,Menzies, Craig, Fineberg, andSahakian) and Medical ResearchCouncil Cognition and BrainSciences Unit (Dr Hampshireand Mr Garyfallidis), Universityof Cambridge, Cambridge,England; and Department ofPsychiatry, University ofMinnesota Medical Center,Minneapolis (Dr Grant andMr Odlaug).
1 Citations
#2Lara MenziesH-Index: 12
Last. Barbara J. SahakianH-Index: 133
view all 12 authors...
El trastorno obsesivo compulsivo (TOC) se caracteriza por pensamientos y comportamientos repetidos asociados con la desregulacion subyacente del circuito frontoestriado. El centro de los modelos neurobiologicos del TOC es la corteza orbitofrontal, una region neural que facilita la flexibilidad conductual tras un feedback negativo (aprendizaje inverso). Nosotros identificamos una activacion anormalmente reducida de diversas regiones corticales, incluyendo la corteza orbitofrontal lateral durante ...