Dipender Gill
Imperial College London
Physical therapyMendelian randomizationStrokeDiabetes mellitusMedicine
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Publications 79
#1Xiaomeng Zhang (Edin.: University of Edinburgh)
#2Dipender Gill (Imperial College London)H-Index: 7
Last. Maria Timofeeva (Medical Research Council)H-Index: 10
view all 11 authors...
#1Marios K. Georgakis (LMU: Ludwig Maximilian University of Munich)H-Index: 8
#2Rainer Malik (LMU: Ludwig Maximilian University of Munich)H-Index: 36
Last. Martin Dichgans (LMU: Ludwig Maximilian University of Munich)H-Index: 77
view all 6 authors...
#1Michael Wainberg (Stanford University)H-Index: 6
#2Dipender Gill (Imperial College London)H-Index: 7
Last. Manuel A. Rivas (Stanford University)H-Index: 29
view all 9 authors...
Parkinson9s disease is characterized by dopaminergic neurodegeneration in the substantia nigra. Although dopaminergic drugs are the mainstay of Parkinson9s treatment, their putative disease-modifying properties remain controversial. We explored whether prescription of dopaminergic stimulants for attention-deficit hyperactivity disorder (ADHD) might affect Parkinson9s incidence. We performed Cox survival analyses for outpatient Parkinson9s diagnosis among ADHD-diagnosed seniors in the Optum Clinf...
#1Ashish Patel (University of Cambridge)
#2Stephen Burgess (University of Cambridge)H-Index: 43
Last. Paul J. Newcombe (University of Cambridge)H-Index: 12
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This paper concerns inference in instrumental variable models with a high-dimensional set of correlated weak instruments. Our focus is motivated by Mendelian randomization, the use of genetic variants as instrumental variables to identify the unconfounded effect of an exposure on disease. In particular, we consider the scenario where a large number of genetic instruments may be exogenous, but collectively they explain a low proportion of exposure variation. Additionally, we assume that individua...
#1Dipender GillH-Index: 7
#2Marios Arvanitis (Johns Hopkins University)H-Index: 1
Last. Amy M. MasonH-Index: 4
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Objectives: To use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk factors to provide insight into how these exposures affect lung ACE2 and TMPRSS2 gene expression and circulating ACE2 levels. Design: Two-sample Mendelian randomization (MR) analysis. Setting: Summary-level genetic association data. Participants: Participants were predominantly of European ancestry. Variants that proxy ACE inhibitor drug effects and cardiometabo...
#1Guido J. Falcone (Yale University)H-Index: 23
#2Elayna P Kirsch (Yale University)
Last. Devin L. Brown (UM: University of Michigan)H-Index: 36
view all 38 authors...
OBJECTIVE: Observational studies point to an inverse correlation between LDL cholesterol levels and risk of intracerebral hemorrhage (ICH), but it remains unclear whether this association is causal. We tested the hypothesis that genetically-elevated LDL is associated with reduced risk of ICH. METHODS: We constructed one polygenic risk score (PRS) per lipid trait (total cholesterol, LDL, HDL and triglycerides) using independent genome-wide significant SNPs for each trait. We used data from 316,42...
#1Saranya Palaniswamy (Imperial College London)H-Index: 3
#2Dipender Gill (Imperial College London)H-Index: 7
Last. Daniel I. Chasman (Brigham and Women's Hospital)H-Index: 98
view all 17 authors...
BACKGROUND: Obesity is associated with inflammation but the role of vitamin D in this process is not clear. OBJECTIVES: We aimed to assess the associations between serum 25-hydroxyvitamin D [25(OH)D], BMI, and 16 inflammatory biomarkers, and to assess the role of vitamin D as a potential mediator in the association between higher BMI and inflammation. METHODS: Northern Finland Birth Cohort 1966 (NFBC1966) 31-y data on 3586 individuals were analyzed to examine the observational associations betwe...
#1Sandro Marini (Harvard University)H-Index: 8
#2Jordi MerinoH-Index: 11
Last. Christopher D. AndersonH-Index: 47
view all 10 authors...
OBJECTIVE: To systematically investigate causal relationships between obesity and cerebrovascular disease and the extent to which hypertension and hyperglycemia mediate the effect of obesity on cerebrovascular disease. METHODS: We used summary statistics from genome-wide association studies for body mass index (BMI), waist-to-hip ratio (WHR), and multiple cerebrovascular disease phenotypes. We explored causal associations with 2-sample Mendelian randomization (MR) accounting for genetic covariat...
3 CitationsSource
#1Verena Zuber (Imperial College London)
#2Dipender Gill (Imperial College London)H-Index: 7
Last. Stephen Burgess (University of Cambridge)H-Index: 43
view all 7 authors...
Background: Genetic variants can be used to prioritize risk factors as potential therapeutic targets via Mendelian randomization (MR). An agnostic statistical framework using Bayesian model averaging (MR-BMA) can disentangle the causal role of correlated risk factors with shared genetic predictors. Here, our objective is to identify lipoprotein measures as mediators between lipid-associated genetic variants and coronary artery disease (CAD) for the purpose of detecting therapeutic targets for CA...
#1Michael G. Levin (UPenn: University of Pennsylvania)H-Index: 1
#2Renae Judy (UPenn: University of Pennsylvania)H-Index: 2
Last. Scott M. Damrauer (UPenn: University of Pennsylvania)H-Index: 17
view all 9 authors...
Objective: To determine whether height has a causal effect on risk of atrial fibrillation Design: Mendelian randomization study Setting: Genome-wide association studies of height and atrial fibrillation; Penn Medicine Biobank Participants: Multiethnic (predominantly European ancestry) participants in genome-wide association studies of height (693,529 individuals) and atrial fibrillation (65,446 cases and 522,744 controls); 7,023 Penn Medicine Biobank participants of European ancestry Exposures: ...