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Vassilios Myrianthopoulos
National and Kapodistrian University of Athens
54Publications
13H-index
588Citations
Publications 57
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#1Efthymios-Spyridon Gavriil (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Aris Doukatas (Academy of Athens)
Last.Nicole Pouli (UoA: National and Kapodistrian University of Athens)H-Index: 15
view all 9 authors...
Abstract Novel substituted purine isosters, were designed and synthesized as potential inhibitors of the Epidermal Growth Factor Receptor (EGFR). The compounds were rationally designed through bioisosteric replacement of the central quinazoline core of lapatinib, an approved drug that inhibits both EGFR and HER2, another important member of this family of receptors. The new target molecules were evaluated as inhibitors of receptor phosphorylation at the cellular level, for their direct inhibitor...
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#1Panagiota-Efstathia Nikolaou (UoA: National and Kapodistrian University of Athens)H-Index: 2
#2Kerstin Boengler (University of Giessen)H-Index: 10
Last.Ioanna Andreadou (UoA: National and Kapodistrian University of Athens)H-Index: 32
view all 16 authors...
2 CitationsSource
1 CitationsSource
#1Sophia V. Rizou (UoA: National and Kapodistrian University of Athens)H-Index: 4
#2Konstantinos Evangelou (UoI: University of Ioannina)H-Index: 2
Last.Vassilis G. GorgoulisH-Index: 47
view all 15 authors...
4 CitationsSource
#1Vassilios Myrianthopoulos (UoA: National and Kapodistrian University of Athens)H-Index: 13
#2Emmanuel Mikros (UoA: National and Kapodistrian University of Athens)H-Index: 28
Abstract The discipline of drug discovery has greatly benefited by computational tools and in silico algorithms aiming at rationalization of many related processes, from the stage of early hit identification to the preclinical phases of drug candidate validation. The various methodologies referred to as molecular modeling tools span a broad spectrum of applications, from straightforward approaches such as virtual screening of compound libraries to more advanced techniques involving the precise e...
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#1Vassilios Myrianthopoulos (UoA: National and Kapodistrian University of Athens)H-Index: 13
#2Konstantinos Evangelou (UoI: University of Ioannina)H-Index: 18
Last.Vassilis G. GorgoulisH-Index: 47
view all 10 authors...
Abstract Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal activation during embryonic development or normal adult life is linked with beneficial properties. In contrast, persistent (chronic) senescence seems to exert detrimental effects fostering aging and age-related disorders, such as cancer. Due to the lack of a reliable marker able to detect senescence in vivo, its precise impact in age-related diseases is to a large extent still undetermined. A novel rea...
11 CitationsSource
#1Erofili Giannakopoulou (UoA: National and Kapodistrian University of Athens)H-Index: 2
#2Vasiliki Pardali (UoA: National and Kapodistrian University of Athens)H-Index: 1
Last.Grigoris Zoidis (UoA: National and Kapodistrian University of Athens)H-Index: 11
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Infections with Flaviviridae viruses, such as hepatitis C virus (HCV) and dengue virus (DENV) pose global health threats. Infected individuals are at risk of developing chronic liver failure or haemorrhagic fever respectively, often with a fatal outcome if left untreated. Diseases caused by tropical parasites of the Trypanosoma species, T. brucei and T. cruzi, constitute significant socioeconomic burden in sub-Saharan Africa and continental Latin America, yet drug development is under-funded. An...
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In the era of precision medicine immunohistochemistry (IHC) and immunocytochemistry (ICC) share some of the highlights in personalized treatment. Survival data obtained from clinical trials shape the cut-offs and IHC scoring that serve as recommendations for patient selection both for targeted and conventional therapies. Assessment of Estrogen and Progesterone Receptors along with HER2 status has been among the first approved immunostaining assays revolutionizing breast cancer treatment. Similar...
#1Sophia V. Rizou (UoA: National and Kapodistrian University of Athens)H-Index: 4
#2Konstantinos Evangelou (UoI: University of Ioannina)H-Index: 18
Last.Vassilis G. GorgoulisH-Index: 47
view all 15 authors...
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#1Maria E Mavrogeni (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Filippos Pronios (UoA: National and Kapodistrian University of Athens)H-Index: 1
Last.Emmanuel Mikros (UoA: National and Kapodistrian University of Athens)H-Index: 28
view all 9 authors...
Background: Virtual screening is vital for contemporary drug discovery but striking performance fluctuations are commonly encountered, thus hampering error-free use. Results and Methodology: A conceptual framework is suggested for combining screening algorithms characterized by orthogonality (docking-scoring calculations, 3D shape similarity, 2D fingerprint similarity) into a simple, efficient and expansible python-based consensus ranking scheme. An original experimental dataset is created for c...
2 CitationsSource
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