Match!
Vassilios Myrianthopoulos
National and Kapodistrian University of Athens
Virtual screeningKinaseChemistryBiochemistryBiology
57Publications
16H-index
973Citations
What is this?
Publications 56
Newest
#1Vasiliki Pardali (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Erofili Giannakopoulou (UoA: National and Kapodistrian University of Athens)H-Index: 3
Last. Grigoris Zoidis (UoA: National and Kapodistrian University of Athens)H-Index: 12
view all 9 authors...
In this report, we extend the SAR analysis of a number of lipophilic guanylhydrazone analogues with respect to in vitro growth inhibition of Trypanosoma brucei and Trypanosoma cruzi. Sleeping sickness and Chagas disease, caused by the tropical parasites T. brucei and T. cruzi, constitute a significant socioeconomic burden in low-income countries of sub-Saharan Africa and Latin America, respectively. Drug development is under-funded. Moreover, current treatments are outdated and difficult to admi...
1 CitationsSource
#1Nikolaos AntoniouH-Index: 6
#1N. G. Antoniou (UoA: National and Kapodistrian University of Athens)H-Index: 11
Last. Vassilis G. GorgoulisH-Index: 51
view all 11 authors...
The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. UBE4B is a newly identified member of E3 ubiquitin ligases that appears to be overexpressed in several human neoplasms. The aim of this review is to pro...
Source
#1Efthymios-Spyridon Gavriil (UoA: National and Kapodistrian University of Athens)H-Index: 2
#2Aris Doukatas (Academy of Athens)H-Index: 1
Last. Nicole Pouli (UoA: National and Kapodistrian University of Athens)H-Index: 16
view all 9 authors...
Abstract Novel substituted purine isosters, were designed and synthesized as potential inhibitors of the Epidermal Growth Factor Receptor (EGFR). The compounds were rationally designed through bioisosteric replacement of the central quinazoline core of lapatinib, an approved drug that inhibits both EGFR and HER2, another important member of this family of receptors. The new target molecules were evaluated as inhibitors of receptor phosphorylation at the cellular level, for their direct inhibitor...
1 CitationsSource
#1Konstantinos Vougas (UoA: National and Kapodistrian University of Athens)H-Index: 20
#1Konstantinos Vougas (UoA: National and Kapodistrian University of Athens)H-Index: 1
Last. Vassilis G. GorgoulisH-Index: 51
view all 21 authors...
Abstract A major challenge in cancer treatment is predicting the clinical response to anti-cancer drugs on a personalized basis. The success of such a task largely depends on the ability to develop computational resources that integrate big “omic” data into effective drug-response models. Machine learning is both an expanding and an evolving computational field that holds promise to cover such needs. Here we provide a focused overview of: 1) the various supervised and unsupervised algorithms use...
5 CitationsSource
#1Erofili Giannakopoulou (UoA: National and Kapodistrian University of Athens)H-Index: 3
#2Vasiliki Pardali (UoA: National and Kapodistrian University of Athens)H-Index: 1
Last. Grigoris Zoidis (UoA: National and Kapodistrian University of Athens)H-Index: 12
view all 10 authors...
Infections with Flaviviridae viruses, such as hepatitis C virus (HCV) and dengue virus (DENV) pose global health threats. Infected individuals are at risk of developing chronic liver failure or haemorrhagic fever respectively, often with a fatal outcome if left untreated. Diseases caused by tropical parasites of the Trypanosoma species, T. brucei and T. cruzi, constitute significant socioeconomic burden in sub-Saharan Africa and continental Latin America, yet drug development is under-funded. An...
Source
#1Panagiota-Efstathia Nikolaou (UoA: National and Kapodistrian University of Athens)H-Index: 3
#2Kerstin Boengler (University of Giessen)H-Index: 11
Last. Ioanna Andreadou (UoA: National and Kapodistrian University of Athens)H-Index: 33
view all 16 authors...
AIMS: Glycogen synthase kinase 3 beta (GSK3β) link with the mitochondrial Permeability Transition Pore (mPTP) in cardioprotection is debated. We investigated the role of GSK3β in ischaemia (I)/reperfusion (R) injury using pharmacological tools. METHODS AND RESULTS: Infarct size using the GSK3β inhibitor BIO (6-bromoindirubin-3'-oxime) and several novel analogues (MLS2776-MLS2779) was determined in anaesthetized rabbits and mice. In myocardial tissue GSK3β inhibition and the specificity of the co...
7 CitationsSource
#1Antonia Efstathiou (Pasteur Institute)H-Index: 4
#2Nicolas Gaboriaud-Kolar (UoA: National and Kapodistrian University of Athens)H-Index: 11
Last. Despina SmirlisH-Index: 14
view all 11 authors...
: The protozoan parasite Trypanosoma brucei is the causative agent of human African trypanosomiasis (HAT). The disease is fatal if it remains untreated, whereas most drug treatments are inadequate due to high toxicity, difficulties in administration, and low central nervous system penetration. T. brucei glycogen synthase kinase 3 short (TbGSK3s) is essential for parasite survival and thus represents a potential drug target that could be exploited for HAT treatment. Indirubins, effective leishman...
2 CitationsSource
#1Tomer Cooks (BGU: Ben-Gurion University of the Negev)H-Index: 2
#1Tomer CooksH-Index: 13
Last. Ioannis S. Pateras (UoA: National and Kapodistrian University of Athens)H-Index: 21
view all 7 authors...
In the era of precision medicine immunohistochemistry (IHC) and immunocytochemistry (ICC) share some of the highlights in personalized treatment. Survival data obtained from clinical trials shape the cut-offs and IHC scoring that serve as recommendations for patient selection both for targeted and conventional therapies. Assessment of Estrogen and Progesterone Receptors along with HER2 status has been among the first approved immunostaining assays revolutionizing breast cancer treatment. Similar...
3 CitationsSource
#1Vassilios Myrianthopoulos (UoA: National and Kapodistrian University of Athens)H-Index: 16
#2Emmanuel Mikros (UoA: National and Kapodistrian University of Athens)H-Index: 28
Abstract The discipline of drug discovery has greatly benefited by computational tools and in silico algorithms aiming at rationalization of many related processes, from the stage of early hit identification to the preclinical phases of drug candidate validation. The various methodologies referred to as molecular modeling tools span a broad spectrum of applications, from straightforward approaches such as virtual screening of compound libraries to more advanced techniques involving the precise e...
Source
#1Vassilios Myrianthopoulos (UoA: National and Kapodistrian University of Athens)H-Index: 16
#2Konstantinos Evangelou (UoI: University of Ioannina)H-Index: 21
Last. Vassilis G. GorgoulisH-Index: 51
view all 10 authors...
Abstract Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal activation during embryonic development or normal adult life is linked with beneficial properties. In contrast, persistent (chronic) senescence seems to exert detrimental effects fostering aging and age-related disorders, such as cancer. Due to the lack of a reliable marker able to detect senescence in vivo, its precise impact in age-related diseases is to a large extent still undetermined. A novel rea...
28 CitationsSource
123456