(CAS: Chinese Academy of Sciences)+ 6 AuthorsSong Xiang1
Estimated H-index: 1
(CAS: Chinese Academy of Sciences)
Background Men are at higher risk of developing chronic lymphocytic leukemia (CLL) than women. DNA methylation has been shown to play important roles in a number of cancers. There are differences in the DNA methylation pattern between men and women. In this study, we investigated whether this contributes to the sex-related difference of B cell CLL risk.
Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre-diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. We used pre-diagnostic biomarker data from 5183 case–control pairs nested within 20 prospective cohorts, and genetic data from 29,2...
(VUMC: Vanderbilt University Medical Center)+ 57 AuthorsQin Wang35
Estimated H-index: 35
(University of Cambridge)
Common genetic variants in 183 loci have been identified in relation to breast cancer risk in genome-wide association studies (GWAS). These risk variants combined explain only a relatively small proportion of breast cancer heritability, particularly in Asian populations. To search for additional genetic susceptibility loci for breast cancer, we performed a meta-analysis of data from GWAS conducted in Asians (24,206 cases and 24,775 controls). Variants showing an association with breast cancer ri...
(IU: Indiana University), Ying Zhang (UNMC: University of Nebraska Medical Center)+ 35 AuthorsXiao-Ou Shu96
Estimated H-index: 96
(VUMC: Vanderbilt University Medical Center)
Objective To study the association of educational level and risk of death from all causes, cardiovascular disease (CVD) and cancer among Asian populations. Design A pooled analysis of 15 population-based cohort studies. Setting and participants 694 434 Asian individuals from 15 prospective cohorts within the Asia Cohort Consortium. Interventions None. Main outcome measures HRs and 95% CIs for all-cause mortality, as well as for CVD-specific mortality and cancer-specific mortality. Results A tota...
Biliary tract cancers are rare but highly fatal with poorly understood etiology. Identifying potentially modifiable risk factors for these cancers is essential for prevention. Here we estimated the relationship between adiposity and cancer across the biliary tract, including cancers of the gallbladder (GBC), intrahepatic bile ducts (IHBDC), extrahepatic bile ducts (EHBDC), and the ampulla of Vater (AVC). We pooled data from 27 prospective cohorts with over 2.7 million adults. Adiposity was measu...