Mi-Kyoung Kim
Pusan National University
Molecular biologyAngiogenesisBiochemistryInterleukin 8Biology
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Publications 40
#1Hyun-Joo ParkH-Index: 12
#2Yeon Jeong KimH-Index: 15
Last. Moon-Kyoung BaeH-Index: 20
view all 7 authors...
Vascular calcification is the pathological deposition of calcium/phosphate in the vascular system and is closely associated with cardiovascular morbidity and mortality. Here, we investigated the role of gastrin-releasing peptide (GRP) in phosphate-induced vascular calcification and its potential regulatory mechanism. We found that the silencing of GRP gene and treatment with the GRP receptor antagonist, RC-3095, attenuated the inorganic phosphate-induced calcification of vascular smooth muscle c...
Pentraxin-3 (PTX3) is recognized as a modulator of inflammation and a mediator of tissue repair. In this study, we characterized the role of PTX3 on some biological functions of human dental pulp stem cells (HDPSCs). The expression level of PTX3 significantly increased during osteogenic/odontogenic differentiation of HDPSCs, whereas the knockdown of PTX3 decreased this differentiation. Silencing of PTX3 in HDPSCs inhibited their migration and C-X-C chemokine receptor type 4 (CXCR4) expression. O...
#3Ki-Soo SeongH-Index: 1
Last. Hye-Ock JangH-Index: 12
view all 11 authors...
#1Yeon Jeong KimH-Index: 15
#3Jooyeon ParkH-Index: 16
Last. Moon-Kyoung BaeH-Index: 20
view all 8 authors...
Gastrin-releasing peptide (GRP), a member of bombesin-like peptides, and its receptor (GRP-R) play an important role in various physiological and pathological conditions. In this work, we investigated the role of GRP-R on adipogenesis in 3T3-L1 adipocytes. The expression of GRP-R was significantly increased during the adipocyte differentiation of 3T3-L1 cells. The inhibition of GRP-R by the antagonist RC-3095 affected adipogenesis in 3T3-L1 cells, which reduced lipid accumulation and regulated t...
#1Yeon Jeong Kim (PNU: Pusan National University)H-Index: 15
#2Jin-Sung Park (PNU: Pusan National University)
Last. Moon-Kyoung Bae (PNU: Pusan National University)H-Index: 20
view all 9 authors...
Abstract Introduction Pentraxin 3 (PTX3) has been suggested as a novel inflammatory biomarker in inflammation-associated diseases. The aim of this study was to examine the role of PTX3 in the inflammatory response of human dental pulp cells (HDPCs). Methods HDPCs were treated with tumor necrosis factor alpha (TNF-α), and total RNA and protein were extracted. PTX3 messenger RNA and protein expression levels were analyzed using reverse transcription polymerase chain reaction and Western blotting, ...
#1Jeong-Oh Shin (Yonsei University)H-Index: 11
#2Jong-Joo Lee (Yonsei University)H-Index: 11
Last. Jinwoong Bok (Yonsei University)H-Index: 16
view all 8 authors...
3 CitationsSource
#1Hyun-Joo Park (PNU: Pusan National University)H-Index: 12
#2Mi-Kyoung Kim (PNU: Pusan National University)H-Index: 12
Last. Moon-Kyoung Bae (PNU: Pusan National University)H-Index: 20
view all 7 authors...
5 CitationsSource
#1KimJi-Young (Yonsei University)H-Index: 141
#2Hemin Lee (Yonsei University)H-Index: 7
Last. Sang Ho Oh (Yonsei University)H-Index: 22
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Abstract Background Nrf2-Keap1 signaling pathway protects cells against photo-oxidative stress. Yet in recent works, its role in melanogenesis together with cell protection functions against oxidative stress has been gaining interest. However, its effect on melanogenesis still has contradictory results from different studies. Objective The aims of our study were to investigate the effect of Keap1 silencing in melanocyte on melanogenesis and its associated mechanism. Methods Primary human epiderm...
1 CitationsSource
#1Tae-Gyun Kim (Yonsei University)H-Index: 15
#2Sueun Kim (Yonsei University)H-Index: 1
Last. Hyoung-Pyo Kim (Yonsei University)H-Index: 18
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Hematopoiesis involves a series of lineage differentiation programs initiated in hematopoietic stem cells (HSCs) found in bone marrow (BM). To ensure lifelong hematopoiesis, various molecular mechanisms are needed to maintain the HSC pool. CCCTC-binding factor (CTCF) is a DNA-binding, zinc-finger protein that regulates the expression of its target gene by organizing higher order chromatin structures. Currently, the role of CTCF in controlling HSC homeostasis is unknown. Using a tamoxifen-inducib...
2 CitationsSource