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Judit Váradi
University of Debrecen
46Publications
15H-index
688Citations
Publications 48
Newest
Abstract Nowadays, the sorbates are the third largest group of antimicrobial preservatives in food and pharmaceutical industries, following the parabens and benzoates whose safety is questioned by recent publications. A disadvantage of sorbates is their pH dependence, as their antimicrobial effect is greatly reduced in alkaline environment. The main, widely used sorbate derivatives are sorbic acid and potassium sorbate, no sorbic acid esters are involved in current industrial application. We aim...
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Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have several applications in the pharmaceutical field like solubility enhancers or the building blocks of larger drug delivery systems. On the other hand, they have numerous effects on cells or biological b...
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#1Gábor Vasvári (University of Debrecen)H-Index: 3
#2Ádám Haimhoffer (University of Debrecen)H-Index: 1
Last.Ferenc Fenyvesi (University of Debrecen)H-Index: 14
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Dosage forms with increased gastric residence time are promising tools to increase bioavailability of drugs with narrow absorption window. Low-density floating formulations could avoid gastric emptying; therefore, sustained drug release can be achieved. Our aim was to develop a new technology to produce low-density floating formulations by melt foaming. Excipients were selected carefully, with the criteria of low gastric irritation, melting range below 70°C and well-known use in oral drug formul...
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#1Ferenc FenyvesiH-Index: 14
#2Judit VáradiH-Index: 15
Last.Peter TakacsH-Index: 17
view all 7 authors...
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#1Judit Váradi (University of Debrecen)H-Index: 15
#2Anca Hermenean (UWO: University of Western Ontario)H-Index: 15
Last.Ferenc Fenyvesi (University of Debrecen)H-Index: 14
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2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is utilized in the formulation of pharmaceutical products and recently orphan designation was granted for the treatment of Niemann–Pick disease, type C. The exact mechanism of HPBCD action and side effects are not completely explained. We used fluorescently labelled hydroxypropyl-beta-cyclodextrin (FITC-HPBCD) to study its pharmacokinetic parameters in mice and compare with native HPBCD data. We found that FITC-HPBCD has fast distribution and elimination...
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#1Petra AranyH-Index: 1
#2Eszter RókaH-Index: 5
Last.Ildikó BácskayH-Index: 15
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3D printing is attracting considerable interest for its capacity to produce prototypes and small production runs rapidly. Fused deposit modeling (FDM) was used to produce polyvalent test plates for investigation of the physical, chemical, and in-vitro biological properties of printed materials. The polyvalent test plates (PVTPs) are poly-lactic acid cylinders, 14 mm in diameter and 3 mm in height. The polymer ester backbone was surface modified by a series of ramified and linear oligoamines to i...
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#2Zsolt FejesH-Index: 5
Last.Béla NagyH-Index: 17
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#1Zsolt BeneH-Index: 3
#2Zsolt FejesH-Index: 5
Last.Béla NagyH-Index: 17
view all 9 authors...
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#1Judit Váradi (University of Debrecen)H-Index: 15
#2Tímea Szűcs (University of Debrecen)
Last.Mária Strenáčiková (University of Debrecen)
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Recent changes in higher education have not left the structure of art education. Now, in accordance with the Bologna Process in Hungary and Slovakia also, music and other arts are taught on two lev...
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#1István Hajdu (University of Debrecen)H-Index: 7
#2János Angyal (University of Debrecen)H-Index: 3
Last.Ferenc Fenyvesi (University of Debrecen)H-Index: 14
view all 16 authors...
Abstract A new renaissance started in the research and application of cyclodextrins a few years ago. 2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is used in the formulation of drugs and recently orphan designation was granted for the treatment of Niemann-Pick disease, type C. HPBCD is considered to be safe, but the exact mechanism of action and side effects are not completely explained. Labeled cyclodextrin derivatives are required to reveal the biological activity and in vivo distribution by imagi...
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