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Gregory T. Jones
University of Otago
142Publications
30H-index
6,686Citations
Publications 142
Newest
#1Gregory T. Jones (University of Otago)H-Index: 30
#2Judith Marsman (University of Otago)H-Index: 4
Last.A.M. van Rij (University of Otago)H-Index: 43
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Recent reports have suggested a reproducible association between the rs11121615 SNP, located within an intron of the castor zinc finger 1 (CASZ1) gene, and varicose veins. This study aimed to determine if this variant is also differentially associated with the various clinical classifications of chronic venous disease (CVD). The rs11121615 SNP was genotyped in two independent cohorts from New Zealand (n = 1876 controls /1606 CVD cases) and the Netherlands (n = 1626/2966). Participants were clini...
#1Amélie PinardH-Index: 2
#2Gregory T. JonesH-Index: 30
Last.Dianna M. MilewiczH-Index: 56
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Dissections or ruptures of aortic aneurysms remain a leading cause of death in the developed world, with the majority of deaths being preventable if individuals at risk are identified and properly ...
#1Amélie Pinard (University of Texas Health Science Center at Houston)H-Index: 2
#2Gregory T. Jones (University of Otago)H-Index: 30
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 56
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#1Gregory T. Jones (University of Otago)H-Index: 30
#2Peter SandifordH-Index: 4
Last.A.M. van Rij (University of Otago)H-Index: 43
view all 9 authors...
Objective Recently, the prevalence of abdominal aortic aneurysm (AAA) using screening strategies based on elevated cardiovascular disease (CVD) risk was reported. AAA was defined as a diameter ≥30 mm, with prevalence of 6.1% and 1.8% in men and women respectively, consistent with the widely reported AAA predominant prevalence in males. Given the obvious differences in body size between sexes this study aimed to re-evaluate the expanded CVD risk based AAA screening dataset to determine the effect...
While a relationship between large infrarenal aortic diameter and both cardiovascular disease (CVD) prevalence and all-cause mortality has been previously suggested, there is also evidence that small aortic size may also be associated with increased CVD risk. We examined a total of 4882 elderly (>50 years) participants (mean age 69.4) by duplex ultrasound to assess infrarenal abdominal aortic diameters and correlated these with each individual's history of CVDs, including ischaemic heart disease...
#1Reade B. Roberts (University of Otago)H-Index: 74
#2Mary C. Wallace (University of Otago)H-Index: 7
Last.Murray L. Barclay (Christchurch Hospital)H-Index: 44
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Background: Up to 20% of patients with inflammatory bowel disease (IBD) who are refractory to thiopurine therapy preferentially produce 6-methylmercaptopurine (6-MMP) at the expense of 6-thioguanine nucleotides (6-TGN), resulting in a high 6-MMP:6-TGN ratio (>20). The objective of this study was to evaluate whether genetic variability in guanine monophosphate synthetase (GMPS) contributes to preferential 6-MMP metabolizer phenotype. Methods: Exome sequencing was performed in a cohort of IBD pati...
#1Euan J. Rodger (University of Otago)H-Index: 11
#2Carolyn M. Porteous (University of Otago)H-Index: 19
Last.Sally P. A. McCormick (University of Otago)H-Index: 21
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Background. Mouse models of hypercholesterolaemia have been used to identify arterial proteins involved in atherosclerosis. As the liver is extremely sensitive to dyslipidemia, one might expect major changes in the abundance of liver proteins in these models even before atherosclerosis develops. Methods. Lipid levels were measured and a proteomic approach was used to quantify proteins in the livers of mice with an elevated low-density lipoprotein (LDL) and the presence of lipoprotein(a) [Lp(a)] ...
#1Manar Khashram (University of Otago)H-Index: 5
#2Giorgi Kvizhinadze (University of Otago)H-Index: 9
Last.Justin A. Roake (University of Otago)H-Index: 23
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Objective/Background Predicting outcomes prior to elective abdominal aortic aneurysm repair (AAA) requires critical decision making, as the treatment offered is a prophylactic procedure to prevent death from a ruptured AAA. The aim of this work was to develop and validate a model that may predict outcomes for patients with an AAA and hence aid in clinical decision making. Methods A discrete event simulation model was built to simulate the natural history of a patient with an AAA and to predict t...
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