Gregory T. Jones
University of Otago
CardiologyAbdominal aortic aneurysmDiabetes mellitusMedicineBiology
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Publications 147
#1Dhananjie N. K. Chandrasekera (University of Otago)H-Index: 1
Last. Philip Davis (University of Otago)H-Index: 5
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: Type 2 diabetes has a strong association with the development of cardiovascular disease, which is grouped as diabetic heart disease (DHD). DHD is associated with the progressive loss of cardiovascular cells through the alteration of molecular signalling pathways associated with cell death. In this study, we sought to determine whether diabetes induces dysregulation of miR-532 and if this is associated with accentuated apoptosis. RT-PCR analysis showed a significant increase in miR-532 expressi...
#1Gregory T. Jones (University of Otago)H-Index: 32
#2Judith Marsman (University of Otago)H-Index: 5
Last. Sally P. A. McCormick (University of Otago)H-Index: 23
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Changes in whole blood DNA methylation levels at several CpG sites have been associated with circulating blood lipids, specifically high-density lipoprotein and triglycerides. This study performs a...
#1Judith Marsman (University of Otago)H-Index: 5
#2Gregory Gimenez (University of Otago)H-Index: 20
Last. Gregory T. Jones (University of Otago)H-Index: 32
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Abdominal aortic aneurysm (AAA) is a major cause of sudden death in the elderly. While AAA has some overlapping genetic and environmental risk factors with atherosclerosis, there are substantial differences, and AAA-specific medication is lacking. A recent meta-analysis of genome-wide association studies has identified four novel single-nucleotide polymorphisms (SNPs) specifically associated with AAA. Here, we investigated the gene regulatory function for one of four non-coding SNPs associated w...
1 CitationsSource
#1Tanjina Kader (University of Otago)H-Index: 1
#2Carolyn M. Porteous (University of Otago)H-Index: 19
Last. Sally P. A. McCormick (University of Otago)H-Index: 23
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Ribose-cysteine is a synthetic compound designed to increase glutathione (GSH) synthesis. Low levels of GSH and the GSH-dependent enzyme, glutathione peroxidase (GPx), is associated with cardiovascular disease (CVD) in both mice and humans. Here we investigate the effect of ribose-cysteine on GSH, GPx, oxidised lipids and atherosclerosis development in apolipoprotein E-deficient (apoE-/-) mice. Female 12-week old apoE-/- mice (n = 15) were treated with 4-5 mg/day ribose-cysteine in drinking wate...
#1Gregory T. Jones (University of Otago)H-Index: 32
#2Judith Marsman (University of Otago)H-Index: 5
Last. A. M. Van Rij (University of Otago)H-Index: 45
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Recent reports have suggested a reproducible association between the rs11121615 SNP, located within an intron of the castor zinc finger 1 (CASZ1) gene, and varicose veins. This study aimed to determine if this variant is also differentially associated with the various clinical classifications of chronic venous disease (CVD). The rs11121615 SNP was genotyped in two independent cohorts from New Zealand (n = 1876 controls /1606 CVD cases) and the Netherlands (n = 1626/2966). Participants were clini...
#1Nisha Nair (University of Otago)H-Index: 5
#2Giorgi Kvizhinadze (University of Otago)H-Index: 10
Last. A. Blakely (University of Otago)
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BACKGROUND: Abdominal aortic aneurysm (AAA) rupture carries a high fatality rate. AAAs can be detected before rupture by abdominal ultrasound imaging, allowing elective repair. Population-based screening for AAA in older men reduces AAA-related mortality by about 40 per cent. The UK began an AAA screening programme offering one-off scans to men aged 65 years in 2009. Sweden has a similar programme. Currently, there is no AAA screening programme in New Zealand. This cost-utility analysis aimed to...
#1Amélie Pinard (University of Texas Health Science Center at Houston)H-Index: 2
#2Gregory T. Jones (University of Otago)H-Index: 32
Last. Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 62
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2 CitationsSource
#1Amélie PinardH-Index: 2
#2Gregory T. JonesH-Index: 32
Last. Dianna M. MilewiczH-Index: 62
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Dissections or ruptures of aortic aneurysms remain a leading cause of death in the developed world, with the majority of deaths being preventable if individuals at risk are identified and properly ...
18 CitationsSource
#1Gregory T. Jones (University of Otago)H-Index: 32
#2Peter SandifordH-Index: 5
Last. A. M. Van Rij (University of Otago)H-Index: 45
view all 9 authors...
Objective Recently, the prevalence of abdominal aortic aneurysm (AAA) using screening strategies based on elevated cardiovascular disease (CVD) risk was reported. AAA was defined as a diameter ≥30 mm, with prevalence of 6.1% and 1.8% in men and women respectively, consistent with the widely reported AAA predominant prevalence in males. Given the obvious differences in body size between sexes this study aimed to re-evaluate the expanded CVD risk based AAA screening dataset to determine the effect...
3 CitationsSource
#1Reade B. Roberts (University of Otago)H-Index: 67
#2Mary C Wallace (University of Otago)H-Index: 7
Last. Murray L. Barclay (Christchurch Hospital)H-Index: 46
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Background: Up to 20% of patients with inflammatory bowel disease (IBD) who are refractory to thiopurine therapy preferentially produce 6-methylmercaptopurine (6-MMP) at the expense of 6-thioguanine nucleotides (6-TGN), resulting in a high 6-MMP:6-TGN ratio (>20). The objective of this study was to evaluate whether genetic variability in guanine monophosphate synthetase (GMPS) contributes to preferential 6-MMP metabolizer phenotype. Methods: Exome sequencing was performed in a cohort of IBD pati...