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Hsin-Su Yu
Kaohsiung Medical University
PathologyImmunologyBiochemistryMedicineBiology
224Publications
33H-index
3,953Citations
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Publications 221
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#1Wen‐Li Hsu (NPUST: National Pingtung University of Science and Technology)
#2Ming‐Hsien Tsai (NPUST: National Pingtung University of Science and Technology)
Last. Tohru Yoshioka (KMU: Kaohsiung Medical University)H-Index: 30
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Aging, cancer, and longevity have been linked to intracellular Ca(2+) signaling and nociceptive transient receptor potential (TRP) channels. We found that TRP canonical 7 (TRPC7) is a nociceptive mechanoreceptor and that TRPC7 channels specifically mediate the initiation of ultraviolet B (UVB)-induced skin aging and tumor development due to p53 gene family mutations. Within 30 min after UVB irradiation, TRPC7 mediated UVB-induced Ca(2+) influx and the subsequent production of reactive oxygen spe...
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#1Jian-He Lu (KMU: Kaohsiung Medical University)H-Index: 2
#2Hsin-Su Yu (KMU: Kaohsiung Medical University)H-Index: 33
Last. Chih-Hung Lee (Memorial Hospital of South Bend)H-Index: 12
view all 3 authors...
Abstract The prevalence of human cancers, including skin, lung, and bladder, are increased in arsenism areas, where humans are exposed to inorganic arsenic (As) from drinking water. The skin is the most sensitive organ of chronic arsenic poisoning. Arsenic-induced skin cancers tend to be multiple and include Bowen’s disease (intraepidermal carcinoma in situ), squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). Arsenic-induced Bowen’s disease (As-BD) is the main and early form of arsen...
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#1Hsin-Wei Huang (CGU: Chang Gung University)H-Index: 1
#2Chih-Hung Lee (CGU: Chang Gung University)H-Index: 12
Last. Hsin-Su Yu (KMU: Kaohsiung Medical University)H-Index: 33
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Arsenic, a metal ubiquitously distributed in the environment, remains an important global health threat. Drinking arsenic-contaminated water is the major route of human exposure. Exposure to arsenic contributes to several malignancies, in the integumentary, respiratory, hepatobiliary, and urinary systems. Cutaneous lesions are important manifestations after long-term arsenic exposure. Arsenical skin cancers usually herald the development of other internal cancers, making the arsenic-induced skin...
2 CitationsSource
#1Ching-Ying WuH-Index: 3
#2Hsin-Su YuH-Index: 33
Last. Jui-Hsiu TsaiH-Index: 4
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BACKGROUND: Behcet's disease (BD) is a recurrent, multisystemic, inflammatory disorder that mainly affects blood vessels. Because recurrent inflammation of blood vessels in the brain plays a crucial role in the development of ischemic stroke, we hypothesized that patients with BD might have an elevated risk of ischemic stroke. This potential association has been suggested in a few case reports, but not epidemiological studies. Hence, the present study aimed to examine the relation between BD and...
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#1Sebastian Yu (UC Davis: University of California, Davis)H-Index: 6
#2Stephen Chu-Sung Hu (KMU: Kaohsiung Medical University)H-Index: 13
Last. Chih-Hung Lee (CGU: Chang Gung University)H-Index: 12
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BACKGROUND: Skin physiology measurement is receiving more attention for detecting vasculopathy in systemic sclerosis (SSc). Laser Doppler flowmetry (LDF) is a widely used physiological measurement to assess cutaneous microcirculation. However, findings of LDF may be subtle during early stage of microangiopathy in SSc. OBJECTIVE: We hypothesized that cold stress test combined with LDF could detect early-stage microangiopathy in patients with SSc. METHODS: A 67-year-old male came with multiple ulc...
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#1Stephen Chu-Sung Hu (KMU: Kaohsiung Medical University)H-Index: 13
#2Chi-Ling Lin (KMU: Kaohsiung Medical University)H-Index: 7
Last. Hsin-Su Yu (KMU: Kaohsiung Medical University)H-Index: 33
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Background Skin aging can be classified as either physiological or pathological aging. Pathological aging is most often due to chronic sunlight exposure (photoaging). Age-dependent changes in dermoscopic features of normal skin have not previously been well defined.
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#1Hsin-Yi TsaiH-Index: 2
Last. Hsin-Su Yu (NIH: National Institutes of Health)H-Index: 33
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Optical measurement is conducted by employing components such as a spectrometer or photodiode (PD) to detect light intensity. However, the size of spectrometer is large because of its complex optical path and component. Moreover, a PD usually detects the total light intensity instead of the intensity of light at a specific wavelength. Therefore, a novel inverse light-emitting diode (LED) sensor was developed to measure light intensity at specific wavelengths because of the reverse effect of LEDs...
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#1Ching-Ying WuH-Index: 3
#2Wen-Li HsuH-Index: 2
Last. Tohru YoshiokaH-Index: 30
view all 9 authors...
Transforming growth factor-β (TGF-β) is an important target for treating systemic sclerosis (SSc). However, our study revealed three levels of TGF-β1 expression in SSc patients, indicating that inhibiting TGF-β is not sufficient to treat SSc. A previous clinical trial also displayed disappointing results. Thus, our study attempted to search for a potential novel approach. Ingenuity Pathway Analysis (IPA) indicated that the SSc pathological pathways were closely associated with store-operated Ca2...
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#1Sebastian YuH-Index: 6
#2Cheng-Che E. Lan (KMU: Kaohsiung Medical University)H-Index: 21
Last. Hsin-Su Yu (KMU: Kaohsiung Medical University)H-Index: 33
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: Photobiomodulation (PBM) therapy is based on the exposure of biological tissues to low-level laser light (coherent light) or light-emitting diodes (LEDs; noncoherent light), leading to the modulation of cellular functions, such as proliferation and migration, which result in tissue regeneration. PBM therapy has important clinical applications in regenerative medicine. Vitiligo is an acquired depigmentary disorder resulting from disappearance of functional melanocytes in the involved skin. Viti...
1 CitationsSource
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