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Sinead King
King's College London
PsychiatryPsychologyAnxietyGlutamate receptorClinical psychology
13Publications
4H-index
72Citations
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Publications 13
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#1Sinead King ('KCL': King's College London)H-Index: 4
#2James M. StoneH-Index: 33
Last. Allan H. YoungH-Index: 77
view all 4 authors...
Neuropsychological dysfunction is a well-established finding in individuals with bipolar disorder type I (BP-I), even during euthymic periods; however, it is less clear whether this also pertains to bipolar disorder type II (BP-II) or those with subthreshold states (SBP; subthreshold bipolar disorder), such as bipolar not otherwise specified (BP-NOS). Herein, we compare the literature regarding neuropsychological performance in BP-II vs BP-I to determine the extent of relative impairment, and we...
1 CitationsSource
#1Sinead King ('KCL': King's College London)H-Index: 4
#2Luke A. Jelen ('KCL': King's College London)H-Index: 3
Last. James M. Stone ('KCL': King's College London)H-Index: 33
view all 7 authors...
BACKGROUND: Two current theories regarding the neuroscientific bases of mood disorders involve alterations in glutamatergic neurotransmission and excessive activation of inflammatory pathways. We hypothesized that glutamate (Glu) levels and peripheral inflammatory markers would be associated with cognitive function, in patients with Bipolar Disorder Type II (BP-II), and that such factors would be associated with psychological treatment outcomes. AIMS: The primary aim of this study was to explore...
Source
#1Luke A. Jelen ('KCL': King's College London)H-Index: 3
#2Sinead King ('KCL': King's College London)H-Index: 4
Last. James M. Stone ('KCL': King's College London)H-Index: 33
view all 6 authors...
Abstract The glutamate system is implicated in the pathophysiology of schizophrenia and mood disorders. Using functional magnetic resonance spectroscopy ( 1 H-fMRS), it is possible to monitor glutamate dynamically in activated brain areas and may give a closer estimate of glutamatergic neurotransmission than standard magnetic resonance spectroscopy. 14 patients with schizophrenia, 15 patients with bipolar disorder II (BPII) and 14 healthy volunteers underwent a 15 min N-back task in a 48s block ...
Source
#1Sinead KingH-Index: 4
#2Luke A. JelenH-Index: 3
Last. James M. StoneH-Index: 33
view all 6 authors...
Source
#1Susanne Fischer ('KCL': King's College London)H-Index: 19
#2Sinead King ('KCL': King's College London)H-Index: 4
Last. Anthony J. Cleare ('KCL': King's College London)H-Index: 52
view all 6 authors...
OBJECTIVE: Around 30-50% of patients with depression and anxiety disorders fail to respond to standard psychological therapy. Given that cortisol affects cognition, patients with altered hypothalamic-pituitary-adrenal (HPA) axis functioning may benefit less from such treatments. To investigate this, reliable pretreatment cortisol measures are needed. METHOD: N = 89 outpatients with depression and anxiety disorders were recruited before undergoing therapy within an Improving Access to Psychologic...
4 CitationsSource
#1Luke A. Jelen (South London and Maudsley NHS Foundation Trust)H-Index: 3
#2Sinead King ('KCL': King's College London)H-Index: 4
Last. James M. Stone ('KCL': King's College London)H-Index: 33
view all 3 authors...
2 CitationsSource
#1Luke A. Jelen ('KCL': King's College London)H-Index: 3
#2Sinead King ('KCL': King's College London)H-Index: 4
Last. James M. Stone ('KCL': King's College London)H-Index: 33
view all 4 authors...
Abnormalities of the glutamate system are increasingly implicated in schizophrenia but their exact nature remains unknown. Proton magnetic resonance spectroscopy (1H-MRS), while fundamental in revealing glutamatergic alterations in schizophrenia, has, until recently, been significantly limited and thought to only provide static measures. Functional magnetic resonance spectroscopy (fMRS), which uses sequential scans for dynamic measurement of a range of brain metabolites in activated brain areas,...
9 CitationsSource
#1Susanne FischerH-Index: 19
#2Sinead KingH-Index: 4
Last. Anthony J. CleareH-Index: 52
view all 6 authors...
Source
#1James M. StoneH-Index: 33
#2Sinead KingH-Index: 4
Last. David J. LythgoeH-Index: 28
view all 5 authors...
Source
#1Nilay Hepgul ('KCL': King's College London)H-Index: 15
#2Sinead King ('KCL': King's College London)H-Index: 4
Last. Anthony J. Cleare ('KCL': King's College London)H-Index: 52
view all 13 authors...
A substantial number of patients do not benefit from first line psychological therapies for the treatment of depression and anxiety. Currently, there are no clear predictors of treatment outcomes for these patients. The PROMPT project aims to establish an infrastructure platform for the identification of factors that predict outcomes following psychological treatment for depression and anxiety. Here we report on the first year of recruitment and describe the characteristics of our sample to date...
8 CitationsSource
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