Hyo Suk Lee
Seoul National University
Publications 333
#1Dong Hee Kim (Stanford University)H-Index: 38
#2Goh Eun Chung (Seoul National University Hospital)H-Index: 16
Last.Chung Yong Kim (SNU: Seoul National University)H-Index: 31
view all 10 authors...
Background & Aims Some studies have examined correlations between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) with nonalcoholic fatty liver disease (NAFLD) or between VAT and NAFLD. We investigated the longitudinal association between body fat distribution (VAT vs SAT) and incidence and regression of NAFLD, adjusting for risk factors, in a large population-based cohort. Methods We collected data from adults who underwent abdominal ultrasonography (to identify liver fat), ...
#1Jong Bin Kim (SNU: Seoul National University)H-Index: 10
#2Minjong Lee (SNU: Seoul National University)H-Index: 11
Last.Yoon Jun Kim (SNU: Seoul National University)H-Index: 36
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Abstract Sorafenib is a systemic chemotherapeutic agent for advanced hepatocellular carcinoma (HCC). The aim of the present study was to evaluate the anticancer effect of sorafenib in cancer stem cell‑like cells, such as side population (SP) cells, in HCC and to analyze the signaling pathway for drug‑resistance. To evaluate the anticancer effects of sorafenib, Huh7 and Huh‑BAT cells were treated with sorafenib, fluorouracil (5‑FU), and sorafenib plus 5‑FU. These cells were examined for growth ra...
#1Min Sun Kwak (Seoul National University Hospital)H-Index: 8
#2Jeong Yoon Yim (Seoul National University Hospital)H-Index: 13
Last.Mi Na Kim (Seoul National University Hospital)H-Index: 2
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Background In patients with diabetes, studies investigating the association between nonalcoholic fatty liver disease (NAFLD) and coronary artery calcium score (CACS) have shown conflicting results. The aim of this study was to evaluate the association between NAFLD and CACS in diabetic patients.
#1Min-Sun Kwak (SNU: Seoul National University)H-Index: 10
#2Su Jong Yu (SNU: Seoul National University)H-Index: 19
Last.Chung Yong Kim (SNU: Seoul National University)H-Index: 31
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Purpose A previous study showed that flavopiridol increased doxorubicin sensitivity in hypoxic hepatocellular carcinoma (HCC) cells by increasing apoptosis through suppressing hypoxia-inducible N-myc downstream-regulated gene-1 (NDRG1) expression. However, this has not been investigated in an in vivo HCC model. Therefore, we aimed to elucidate whether the combination of doxorubicin and flavopiridol has a synergistic anti-tumor effect in an in vivo HCC model.
#1Su Jong Yu (SNU: Seoul National University)H-Index: 19
#2Seyeon Bae (SNU: Seoul National University)H-Index: 10
Last.Hyo Suk Lee (SNU: Seoul National University)H-Index: 47
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Abstract Prevention and restoration of hepatic fibrosis from chronic liver injury is essential for the treatment of patients with chronic liver diseases. Vitamin C is known to have hepatoprotective effects, but their underlying mechanisms are unclear, especially those associated with hepatic fibrosis. Here, we analyzed the impact of vitamin C on bile acid induced hepatocyte apoptosis in vitro and lithocholic acid (LCA)-induced liver injury in vitamin C-insufficient Gulo(−/−) mice, which cannot s...
#1Hyun Sub Cheong (Sogang University)H-Index: 26
#2Jeong-Hoon Lee (SNU: Seoul National University)H-Index: 22
Last.Suhg Namgoong (Sogang University)H-Index: 5
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Background & Aims Hepatitis B virus (HBV) infection is the most serious risk factor for chronic hepatitis B (CHB), cirrhosis, and hepatocellular carcinoma. Recently, several genome-wide association studies (GWASs) identified important variants associated with the risk of CHB in Asian populations. Specifically, our previous GWAS identified the VARS2-SFTA2 gene region as one of the genetic risk loci for CHB. Methods To further characterize this association and to isolate possible causal variants w...
#1Won Mook Choi (SNU: Seoul National University)H-Index: 14
#2Jeong-Hoon Lee (SNU: Seoul National University)H-Index: 22
Last.Yun Bin Lee (SNU: Seoul National University)H-Index: 8
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Background & Aims Advanced liver fibrosis is associated with recurrence after curative resection of hepatocellular carcinoma (HCC). This study aimed to investigate whether noninvasive fibrosis indices could predict intrahepatic recurrence and death after curative resection of HCC. Methods Patients who underwent curative resection for hepatitis B virus (HBV)-related HCC between 2006 and 2010 at a single tertiary hospital were included. This study analysed the association of noninvasive fibrosis i...
#1Eun Ju Cho (SNU: Seoul National University)H-Index: 15
#2Jeong-Hoon Lee (SNU: Seoul National University)H-Index: 22
Last.Jung-Hwan Yoon (SNU: Seoul National University)H-Index: 33
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The efficacy of entecavir (ETV) and tenofovir (TDF) for the treatment of nucleos(t)ide analogue (NA)-experienced chronic hepatitis B (CHB) patients has been little studied. Here, we compare the efficacy of both ETV and TDF in NA-experienced CHB patients without detectable genotypic resistance. This retrospective cohort study included consecutive NA-experienced patients who had neither current nor previous genotypic resistance and had received ETV or TDF for at least 6 months. Overall, 202 patien...