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Haili Huang
Guangdong Medical College
10Publications
8H-index
150Citations
Publications 10
Newest
#1Yahong WangH-Index: 11
#2Ting ChenH-Index: 7
Last.Gang LiuH-Index: 18
view all 12 authors...
// Yahong Wang 1, * , Ting Chen 1, * , Haili Huang 1 , Yun Jiang 1 , Lawei Yang 1 , Ziying Lin 1 , Huijuan He 1 , Tie Liu 4 , Bin Wu 2 , Jie Chen 3 , David W. Kamp 5 , Gang Liu 1, 2 1 Clinical Research Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China 2 Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China 3 Department of Cardiothoracic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China 4 ...
#1Haili HuangH-Index: 8
#2Ya-Peng ShiH-Index: 2
Last.Gang LiuH-Index: 18
view all 11 authors...
Background: Our previous study identified a novel microRNA, miR-4673, which is upregulated in A549 cells exposed to paclitaxel (PTX). In this study, we investigated the role of miR-4673 in PTX-induced cytotoxicity. Methods: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, apoptosis assay, 5,5’,6,6’-Tetrachloro-1,1’,3,3’-tetraethyl-imidacarbocyanine iodide (JC-1) staining and 2’,7’-Dichlorofluorescein (DCFH) staining were used to evaluate cell viability, apoptosis, mitoc...
#1Yahong WangH-Index: 11
#2Jie ChenH-Index: 4
Last.Gang LiuH-Index: 18
view all 10 authors...
Non-small cell lung cancer (NSCLC) is responsible for the highest number of cancer-associated mortalities worldwide, and the five-year survival rate is <15% following the initial diagnosis. MicroRNAs (miRNAs) serve important functions in a number of human diseases, including cancer. The present study investigated the expression status, clinical relevance and functional role of miRNA in NSCLC. miRNA expression profiling was performed in lung adenocarcinoma and adjacent unaffected lung tissues usi...
#1Lawei Yang (Guangdong Medical College)H-Index: 12
#2Yahong Wang (Guangdong Medical College)H-Index: 11
Last.Gang Liu (Guangdong Medical College)H-Index: 18
view all 13 authors...
Abstract The enzyme 8-oxoguanine glycosylase 1 (OGG1) has been shown to be involved in the repair of oxidative DNA damage. However, the effect of OGG1 on oxidative DNA damage caused by particulate matter 2.5 (PM2.5) is unknown. Herein, we demonstrated that OGG1 could inhibit the generation of ROS and alleviate mitochondrial dysfunction and increased the expression of IL-1β caused by PM2.5. The dichlorodihydrofluorescein diacetate (DCFH-DA) staining and 5,5′,6,6′-tetrachloro-1,1′,3,3′-. tetraethy...
#1Tie Liu (Guangdong Medical College)H-Index: 5
#2Bin Wu (Guangdong Medical College)H-Index: 5
Last.Gang Liu (Guangdong Medical College)H-Index: 18
view all 14 authors...
Abstract Particulate matter 2.5 (PM2.5) is a significant risk factor for asthma. A recent study revealed that autophagy was associated with asthma pathogenesis. However, the specific mechanisms underlying PM2.5-induced autophagy in asthma have remained elusive. In the present study, PM2.5-induced autophagy was evaluated in Beas-2B human bronchial epithelial cells and the potential molecular mechanisms were investigated. Using electron microscopy, immunofluorescence staining and immunoblot studie...
#1Haili Huang (Guangdong Medical College)H-Index: 8
#2Yun Jiang (Guangdong Medical College)H-Index: 8
Last.Gang Liu (Guangdong Medical College)H-Index: 18
view all 12 authors...
Abstract Our previous study demonstrated that microRNA 5100 (miR-5100) is overexpressed in lung cancer tissues; however, the function of miR-5100 remained elusive. In this study, we demonstrate that miR-5100 is highly expressed in a wide variety of lung cancer tissues and lung cancer cell lines. Exogenous expression of miR-5100 in A549 and H1299 lung cancer cells enhanced proliferation and colony formation, and conversely, suppression of miR-5100 exhibited inhibitory effects. Furthermore, we dem...
#1Haili HuangH-Index: 8
#2Yun JiangH-Index: 8
Last.Gang LiuH-Index: 18
view all 13 authors...
FBXO31 is a member of F-box family which is involved in diverse biological functions and development of disease. Recent reports in breast cancer, hepatocellular carcinoma and ovarian cancer demonstrated inhibitory effect of FBXO31 on proliferation and tumorigenesis. However, the function of FBXO31 is not analyzed in lung cancer so far. In this study, we reported that expression of FBXO31 was higher in lung cancer tissues compared with non-cancerous lung tissues, and that higher expression of FBX...
#1Yahong Wang (Guangdong Medical College)H-Index: 11
#2Lawei Yang (Guangdong Medical College)H-Index: 12
Last.Gang Liu (Guangdong Medical College)H-Index: 18
view all 13 authors...
BACKGROUND: MicroRNAs (miRNAs) exist stably and reproducibly in plasma and may be used as biomarkers for various diseases. Little is known about circulating miRNAs in the peripheral blood of juvenile patients with asthma. METHODS: In this study, we used hybridization arrays to compare the miRNA expression profiles among 6 juvenile patients with or without asthma. Using quantitative PCR (qPCR), we verified the expression levels of these miRNAs in plasma from patients with asthma (n = 40) and heal...
#1Yahong Wang (Guangdong Medical College)H-Index: 11
#2Ziying Lin (Guangdong Medical College)H-Index: 12
Last.Gang Liu (Guangdong Medical College)H-Index: 18
view all 13 authors...
The aim is to investigate the molecular mechanisms underlying the PM2.5-induced autophagy in human lung cancer epithelial cells (A549). The effects of the PM2.5 on morphological and biochemical markers of autophagy in A549 were analyzed by electron microscopy, GFP-LC3 puncta was observed by confocal fluorescence microscope. The effects of phosphorylation of AMPK, mTOR, AKT, ERK, JNK, and p53 on LC3II in A549 were observed following PM2.5 exposure; the role of autophagy in PM2.5-induced apoptosis...
#1Jin-Feng TangH-Index: 2
#2Zhong-Hua YuH-Index: 1
Last.Gang LiuH-Index: 18
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MicroRNAs (miRNAs) play an essential role in the development and progression of nasopharyngeal carcinomas (NPC). Despite advances in the field of cancer molecular biology and biomarker discovery, the development of clinically validated biomarkers for primary NPC has remained elusive. In this study, we investigated the expression and clinical significance of miRNAs as novel primary NPC diagnostic biomarkers. We used an array containing 2, 500 miRNAs to identify 22 significant miRNAs, and these ca...
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