Match!
Andrzej Mogielnicki
Medical University of Białystok
46Publications
15H-index
661Citations
Publications 47
Newest
Source
#1Joanna MikloszH-Index: 2
#2Bartlomiej KalaskaH-Index: 6
Last.Andrzej MogielnickiH-Index: 15
view all 8 authors...
Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced aggregation, P-selectin, platelet factor 4, β-thromboglobulin, prostacyclin metabolite, D-dimers, activated partial thromboplastin time, prothrombin time, anti-factor Xa, fibrinogen, thrombus weight a...
Source
#1Bartlomiej Kalaska (UMB: Medical University of Białystok)H-Index: 6
#2Joanna Miklosz (UMB: Medical University of Białystok)H-Index: 2
Last.Andrzej Mogielnicki (UMB: Medical University of Białystok)H-Index: 15
view all 9 authors...
Besides regulating ligand–receptor and cell–cell interactions, heparan sulfate (HS) may participate in the development of many diseases, such as cancer, bacterial or viral infections, and their complications, like bleeding or inflammation. In these cases, the neutralization of HS could be a potential therapeutic target. The heparin-binding copolymer (HBC, PEG41-PMAPTAC53) was previously reported by us as a fully synthetic compound for efficient and safe neutralization of heparins and synthetic a...
2 CitationsSource
Source
#1Bartlomiej Kalaska (UMB: Medical University of Białystok)H-Index: 6
#2Kamil Kamiński (Jagiellonian University)H-Index: 10
Last.Krzysztof Szczubiałka (Jagiellonian University)H-Index: 18
view all 9 authors...
Di- and triblock copolymers with low dispersity of molecular weight were synthesized using radical addition–fragmentation chain transfer polymerization. The copolymers contained anionic poly(sodium 2-acrylamido-2-methylpropanesulfonate) (PAMPS) block as an anticoagulant component. The block added to lower the toxicity was either poly(ethylene glycol) (PEG) or poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC). The polymers prolonged clotting times both in vitro and in vivo. The influence of...
1 CitationsSource
#1Joanna Miklosz (UMB: Medical University of Białystok)H-Index: 2
#2Bartlomiej Kalaska (UMB: Medical University of Białystok)H-Index: 6
Last.Andrzej Mogielnicki (UMB: Medical University of Białystok)H-Index: 15
view all 7 authors...
Source
#1Joanna MikloszH-Index: 2
#2Bartlomiej KalaskaH-Index: 6
Last.Andrzej MogielnickiH-Index: 15
view all 4 authors...
Protamine is widely used to neutralize the anticoagulant effects of unfractionated heparin, particularly after cardiac surgery. Recent reports suggest that some patients undergoing cardiopulmonary bypass exposed to heparin and protamine may develop thrombocytopenia. Multimolecular protamine-heparin complexes lead to immunization and production of immunoglobulin G class antibodies that may activate platelets through FcγIIa receptors. Some patients injected with protamine during cardiopulmonary by...
Source
#1Krzysztof Szczubiałka (Jagiellonian University)H-Index: 18
#2Bartlomiej Kalaska (UMB: Medical University of Białystok)H-Index: 6
Last.Andrzej Mogielnicki (UMB: Medical University of Białystok)H-Index: 15
view all 11 authors...
#1Bartlomiej Kalaska (UMB: Medical University of Białystok)H-Index: 6
#2Kamil Kamiński (Jagiellonian University)H-Index: 10
Last.Andrzej Mogielnicki (UMB: Medical University of Białystok)H-Index: 15
view all 12 authors...
The parenteral anticoagulants may cause uncontrolled and life-threatening bleeding. Protamine, the only registered heparin antidote, is partially effective against low–molecular weight heparins, completely ineffective against fondaparinux and may cause unacceptable toxicity. Therefore, we aimed to develop a synthetic compound for safe and efficient neutralization of all parenteral anticoagulants. We synthesized pegylated PMAPTAC block copolymers, and then, we selected a lead heparin-binding copo...
6 CitationsSource
#1Emilia Sokolowska (UMB: Medical University of Białystok)H-Index: 5
#2Bartlomiej Kalaska (UMB: Medical University of Białystok)H-Index: 6
Last.Andrzej Mogielnicki (UMB: Medical University of Białystok)H-Index: 15
view all 4 authors...
ABSTRACTIntroduction: Unfractionated heparin is a strongly anionic anticoagulant used extensively in medicine to prevent blood clotting. In the case of an emergency bleeding in response to heparin, the protamine sulfate is administered. Despite its extensive clinical use, protamine may produce life-threatening side effects such as systemic hypotension, catastrophic pulmonary vasoconstriction or allergic reactions. Recent studies have demonstrated new organ-specific complications of the heparin r...
18 CitationsSource
12345