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Andrzej Mogielnicki
Medical University of Białystok
45Publications
14H-index
618Citations
Publications 45
Newest
Published on Jan 1, 2019in RSC Advances3.05
Bartlomiej Kalaska6
Estimated H-index: 6
(UMB: Medical University of Białystok),
Joanna Miklosz2
Estimated H-index: 2
(UMB: Medical University of Białystok)
+ 6 AuthorsAndrzej Mogielnicki14
Estimated H-index: 14
(UMB: Medical University of Białystok)
Besides regulating ligand–receptor and cell–cell interactions, heparan sulfate (HS) may participate in the development of many diseases, such as cancer, bacterial or viral infections, and their complications, like bleeding or inflammation. In these cases, the neutralization of HS could be a potential therapeutic target. The heparin-binding copolymer (HBC, PEG41-PMAPTAC53) was previously reported by us as a fully synthetic compound for efficient and safe neutralization of heparins and synthetic a...
Published on Jul 9, 2018in Biomacromolecules5.67
Bartlomiej Kalaska6
Estimated H-index: 6
(UMB: Medical University of Białystok),
Kamil Kamiński9
Estimated H-index: 9
(Jagiellonian University)
+ 6 AuthorsKrzysztof Szczubiałka18
Estimated H-index: 18
(Jagiellonian University)
Di- and triblock copolymers with low dispersity of molecular weight were synthesized using radical addition–fragmentation chain transfer polymerization. The copolymers contained anionic poly(sodium 2-acrylamido-2-methylpropanesulfonate) (PAMPS) block as an anticoagulant component. The block added to lower the toxicity was either poly(ethylene glycol) (PEG) or poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC). The polymers prolonged clotting times both in vitro and in vivo. The influence of...
Published on Apr 1, 2018in Cardiovascular Research7.01
Joanna Miklosz2
Estimated H-index: 2
(UMB: Medical University of Białystok),
Bartlomiej Kalaska6
Estimated H-index: 6
(UMB: Medical University of Białystok)
+ 4 AuthorsAndrzej Mogielnicki14
Estimated H-index: 14
(UMB: Medical University of Białystok)
Published on Sep 19, 2017in Folia Cardiologica
Joanna Miklosz2
Estimated H-index: 2
,
Bartlomiej Kalaska6
Estimated H-index: 6
+ 1 AuthorsAndrzej Mogielnicki14
Estimated H-index: 14
Protamine is widely used to neutralize the anticoagulant effects of unfractionated heparin, particularly after cardiac surgery. Recent reports suggest that some patients undergoing cardiopulmonary bypass exposed to heparin and protamine may develop thrombocytopenia. Multimolecular protamine-heparin complexes lead to immunization and production of immunoglobulin G class antibodies that may activate platelets through FcγIIa receptors. Some patients injected with protamine during cardiopulmonary by...
Published on Jan 1, 2017in Engineering of Biomaterials
Krzysztof Szczubiałka18
Estimated H-index: 18
(Jagiellonian University),
Bartlomiej Kalaska6
Estimated H-index: 6
(UMB: Medical University of Białystok)
+ 8 AuthorsMaria Nowakowska26
Estimated H-index: 26
(Jagiellonian University)
Published on Nov 1, 2016in Translational Research4.92
Bartlomiej Kalaska6
Estimated H-index: 6
(UMB: Medical University of Białystok),
Kamil Kamiński9
Estimated H-index: 9
(Jagiellonian University)
+ 9 AuthorsDariusz Pawlak23
Estimated H-index: 23
(UMB: Medical University of Białystok)
The parenteral anticoagulants may cause uncontrolled and life-threatening bleeding. Protamine, the only registered heparin antidote, is partially effective against low–molecular weight heparins, completely ineffective against fondaparinux and may cause unacceptable toxicity. Therefore, we aimed to develop a synthetic compound for safe and efficient neutralization of all parenteral anticoagulants. We synthesized pegylated PMAPTAC block copolymers, and then, we selected a lead heparin-binding copo...
Published on Aug 2, 2016in Expert Opinion on Drug Metabolism & Toxicology3.49
Emilia Sokolowska4
Estimated H-index: 4
(UMB: Medical University of Białystok),
Bartlomiej Kalaska6
Estimated H-index: 6
(UMB: Medical University of Białystok)
+ 1 AuthorsAndrzej Mogielnicki14
Estimated H-index: 14
(UMB: Medical University of Białystok)
ABSTRACTIntroduction: Unfractionated heparin is a strongly anionic anticoagulant used extensively in medicine to prevent blood clotting. In the case of an emergency bleeding in response to heparin, the protamine sulfate is administered. Despite its extensive clinical use, protamine may produce life-threatening side effects such as systemic hypotension, catastrophic pulmonary vasoconstriction or allergic reactions. Recent studies have demonstrated new organ-specific complications of the heparin r...
Published on Mar 17, 2016in Frontiers in Pharmacology3.85
Emilia Sokolowska4
Estimated H-index: 4
(UMB: Medical University of Białystok),
Bartlomiej Kalaska6
Estimated H-index: 6
(UMB: Medical University of Białystok)
+ 8 AuthorsMaria Nowakowska26
Estimated H-index: 26
(Jagiellonian University)
Though protamine sulfate is the only approved antidote of unfractionated heparin (UFH), yet may produce life threatening side effects such as systemic hypotension, catastrophic pulmonary vasoconstriction or allergic reactions. We have described 40 kDa dextrans (Dex40) substituted with glycidyltrimethylammonium chloride (GTMAC) as effective, immunogenically and hemodynamically neutral inhibitors of UFH. The aim of the present study was to evaluate in mice and rats toxicokinetic profile of the mos...
Published on Mar 17, 2015in PLOS ONE2.78
Bartlomiej Kalaska6
Estimated H-index: 6
(UMB: Medical University of Białystok),
Kamil Kamiński9
Estimated H-index: 9
(Jagiellonian University)
+ 8 AuthorsMaria Nowakowska26
Estimated H-index: 26
(Jagiellonian University)
Protamine, the only registered antidote of unfractionated heparin (UFH), may produce a number of adverse effects, such as anaphylactic shock or serious hypotension. We aimed to develop an alternative UFH antidote as efficient as protamine, but safer and easier to produce. As a starting material, we have chosen generally non-toxic, biocompatible, widely available, inexpensive, and easy to functionalize polysaccharides. Our approach was to synthesize, purify and characterize cationic derivatives o...
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