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Md. Rizwanullah
Jamia Hamdard
CancerIn vivoChemotherapyMedicinePharmacology
18Publications
5H-index
71Citations
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Publications 23
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Abstract Acyclovir (ACV) is an antiviral drug given as tablet that has variable and incomplete absorption from the gastrointestinal tract. Also the absorption is saturated with multi-dose regime leading to only 10-20% bioavailability. Since the drug absorption site is the upper segment of the small intestine so we hypothesised that absorption of acyclovir would increase through novel carriers such as bilosomes which are resistant to digestive enzymes disruption and offer greater drug absorption ...
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#1Md. RizwanullahH-Index: 5
Last. Saima AminH-Index: 13
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#1Md. Abul BarkatH-Index: 3
#1Abul BarkatH-Index: 6
Last. HarshitaH-Index: 4
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Nanoemulsions (NEs) or nanometric-scaled emulsions are transparent or translucent, optically isotropic and kinetically stable heterogeneous system of two immiscible liquids namely, water and oil stabilized with an amphiphilic surfactant having droplet size ranges up to 100 nm. It offers a variety of potential benefits for certain applications: improved long-term stability; high optical clarity; and, enhanced bioavailability due to its nanoscale of particles. Though there is still comparatively n...
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#1Md. Rizwanullah (Jamia Hamdard)H-Index: 5
#2Meraj Alam (Jamia Hamdard)
Last. Saima Amin (Jamia Hamdard)H-Index: 13
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At present, cancer is the most deadly disease and one of the most common causes of death worldwide providing different obstacles to chemotherapy including non-specific biodistribution of chemotherapeutic drugs, dose-related adverse effects, development of metastasis and chemoresistance. Nanoparticle-based targeted delivery of chemotherapeutics gained enormous attention in the treatment of solid tumors as they provide many significant advantages including prolonged drug release, enhanced systemic...
2 CitationsSource
#1Md. RizwanullahH-Index: 5
#2Sadaf Jamal GilaniH-Index: 7
Last. Syed Sarim ImamH-Index: 1
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#1Mohammad Ahmed Khan (Jamia Hamdard)H-Index: 5
#2Vineet JainH-Index: 2
Last. Keerti JainH-Index: 19
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Triple-negative breast cancer (TNBC) is a highly malignant subtype of breast cancer associated with poor prognosis. Although conventional chemotherapy regimens have shown some effectiveness in early TNBC cases, the outcome in advanced stages is poor. The PI3K/AKT/mTOR pathway is one of the important and active pathways involved in chemoresistance and survival of TNBC. This pathway is speculated to play an important part in malignant transformation and has been considered as a potential molecular...
2 CitationsSource
#1Asiya Mahtab (Jamia Hamdard)H-Index: 1
#2Md. Rizwanullah (Jamia Hamdard)H-Index: 5
Last. Sushama Talegaonkar (Jamia Hamdard)H-Index: 28
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Abstract The objective of the present research was to develop teriflunomide-loaded nanoliposomes by thin-film hydration technique for the management of rheumatoid arthritis. Quality by design approach was applied statistically for the optimization of the teriflunomide-nanoliposomalformulation. The vesicle size, polydispersity index, zeta potential and entrapment efficiency of the optimized teriflunomide-nanoliposomal formulation was found to be 128.92 ± 5.42 nm, 0.206 ± 0.06, +12.6 ± 1.2 mV and ...
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#1Md. Rizwanullah (Jamia Hamdard)H-Index: 5
#2Javed AhmadH-Index: 14
Last. Mahfoozur Rahman (H.I., S.I.: University of Agriculture, Faisalabad)H-Index: 16
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#1Sadaf Jamal GilaniH-Index: 7
#2Md. Rizwanullah (Jamia Hamdard)H-Index: 5
Last. Sarwar Beg (Hamdard University)H-Index: 20
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Abstract Pharmaceutical quality by design (QbD) widely used in the optimization of transdermal and topical delivery systems. These approaches mainly depend upon the understanding of both the product and the process. The purpose of this chapter is to provide a background of different QbD approach in different transdermal drug delivery systems (TDDS). The optimization processes is required for an accurate research in these fields and therefore, the right implementation is carried out for different...
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