Match!
Armaz Aschrafi
Laboratory of Molecular Biology
56Publications
25H-index
1,877Citations
Publications 56
Newest
#1Armaz Aschrafi (LMB: Laboratory of Molecular Biology)H-Index: 25
#2Adama Berndt (LMB: Laboratory of Molecular Biology)H-Index: 1
Last.Barry B. Kaplan (LMB: Laboratory of Molecular Biology)H-Index: 18
view all 6 authors...
2 CitationsSource
#1Jenna R. Gale (LMB: Laboratory of Molecular Biology)H-Index: 3
#2Armaz Aschrafi (LMB: Laboratory of Molecular Biology)H-Index: 25
Last.Barry B. Kaplan (LMB: Laboratory of Molecular Biology)H-Index: 18
view all 4 authors...
Axons, their growth cones, and synaptic nerve terminals are neuronal subcompartments that have high energetic needs. As such, they are enriched in mitochondria, which supply the ATP necessary to meet these demands. To date, a heterogeneous population of nuclear-encoded mitochondrial mRNAs has been identified in distal axons and growth cones. Accumulating evidence suggests that the local translation of these mRNAs is required for mitochondrial maintenance and axonal viability. Here, we review evi...
7 CitationsSource
#1C.D. Schoen (Radboud University Nijmegen)H-Index: 1
#2Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
Last.J.W. Von den Hoff (Radboud University Nijmegen)H-Index: 19
view all 7 authors...
6 CitationsSource
#1Amanda Jager (Radboud University Nijmegen)H-Index: 3
#2Houshang Amiri (Radboud University Nijmegen)H-Index: 10
Last.Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
view all 10 authors...
Abstract Reduced top-down control by cortical areas is assumed to underlie pathological forms of aggression. While the precise underlying molecular mechanisms are still elusive, it seems that balancing the excitatory and inhibitory tones of cortical brain areas has a role in aggression control. The molecular mechanisms underpinning aggression control were examined in the BALB/cJ mouse model. First, these mice were extensively phenotyped for aggression and anxiety in comparison to BALB/cByJ contr...
6 CitationsSource
#1Aron Kos (Radboud University Nijmegen)H-Index: 8
#2Annetrude Johanne de Mooij-Malsen (Radboud University Nijmegen)H-Index: 2
Last.Armaz Aschrafi (LMB: Laboratory of Molecular Biology)H-Index: 25
view all 7 authors...
AbstractThe precise spatial and temporal regulation of gene expression orchestrates the many intricate processes during brain development. In the present study we examined the role of the brain-enriched microRNA-338 (miR-338) during mouse cortical development. Reduction of miR-338 levels in the developing mouse cortex, using a sequence-specific miR-sponge, resulted in a loss of neuronal polarity in the cortical plate and significantly reduced the number of neurons within this cortical layer. Con...
2 CitationsSource
#1Aron Kos (Radboud University Nijmegen)H-Index: 8
#2T. Klein-Gunnewiek (Radboud University Nijmegen)H-Index: 1
Last.Armaz Aschrafi (NIH: National Institutes of Health)H-Index: 25
view all 9 authors...
MicroRNAs (miRs) are small non-coding RNAs that confer robustness to gene networks through post-transcriptional gene regulation. Previously, we identified miR-338 as a modulator of axonal outgrowth in sympathetic neurons. In the current study, we examined the role of miR-338 in the development of cortical neurons and uncovered its downstream mRNA targets. Long-term inhibition of miR-338 during neuronal differentiation resulted in reduced dendritic complexity and altered dendritic spine morpholog...
13 CitationsSource
#1Nikkie F.M. Olde Loohuis (Radboud University Nijmegen)H-Index: 6
#2Gerard J. M. Martens (Radboud University Nijmegen)H-Index: 40
Last.Armaz Aschrafi (LMB: Laboratory of Molecular Biology)H-Index: 25
view all 6 authors...
Autism spectrum disorders (ASD) are a highly heterogeneous group of neurodevelopmental disorders caused by complex interplay between various genes and environmental factors during embryonic development. Changes at the molecular, cellular and neuroanatomical levels are especially evident in the medial prefrontal cortex (mPFC) of ASD patients and are particularly contributing to social impairments. In the present study we tested the hypothesis that altered neuronal development and plasticity, as s...
3 CitationsSource
#1Armaz Aschrafi (NIH: National Institutes of Health)H-Index: 25
#2Anthony E. Gioio (NIH: National Institutes of Health)H-Index: 15
Last.Barry B. Kaplan (NIH: National Institutes of Health)H-Index: 18
view all 4 authors...
Abstract Tyrosine hydroxylase (TH) is the enzyme that catalyzes the rate-limiting step in the biosynthesis of the catecholamine neurotransmitters. In a previous communication, evidence was provided that TH mRNA is trafficked to the axon, where it is locally translated. In addition, a 50-bp sequence element in the 3′untranslated region (3’UTR) of TH mRNA was identified that directs TH mRNA to distal axons (i.e., zip-code). In the present study, the hypothesis was tested that local translation of ...
4 CitationsSource
#1Armaz Aschrafi (LMB: Laboratory of Molecular Biology)H-Index: 25
#2Anthony E. Gioio (LMB: Laboratory of Molecular Biology)H-Index: 15
Last.Barry B. Kaplan (NIH: National Institutes of Health)H-Index: 18
view all 4 authors...
Source
#1Christian Schoen (Radboud University Nijmegen)H-Index: 1
#2Armaz Aschrafi (LMB: Laboratory of Molecular Biology)H-Index: 25
Last.Carine Carels (Katholieke Universiteit Leuven)H-Index: 29
view all 6 authors...
Palatogenesis requires a precise spatiotemporal regulation of gene expression, which is controlled by an intricate network of transcription factors and their corresponding DNA motifs. Even minor perturbations of this network may cause cleft palate, the most common congenital craniofacial defect in humans. MicroRNAs (miRNAs), a class of small regulatory non-coding RNAs, have elicited strong interest as key regulators of embryological development, and as etiological factors in disease. MiRNAs func...
9 CitationsSource
123456