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Alexander J. Lazar
University of Texas MD Anderson Cancer Center
486Publications
71H-index
17.2kCitations
Publications 486
Newest
#1Shefali Chopra (SC: University of Southern California)H-Index: 6
#2Alexander J. Lazar (University of Texas MD Anderson Cancer Center)H-Index: 71
Last.Wei Lien Wang (University of Texas MD Anderson Cancer Center)H-Index: 27
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Context.— The performance of laboratory testing has recently come under increased scrutiny as part of important and ongoing debates on regulation and reimbursement. To address this critical issue, ...
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#1Florent PetitprezH-Index: 7
#2A de ReynièsH-Index: 7
Last.Wolf-Hervé Fridman (University of Paris)H-Index: 1
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#1John S.A. Chrisinger (University of Texas MD Anderson Cancer Center)H-Index: 3
#2Tariq Al-ZaidH-Index: 5
Last.Wei Lien Wang (University of Texas MD Anderson Cancer Center)H-Index: 27
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#1Eric R. Molina (Rice University)H-Index: 3
#2Letitia K. Chim (Rice University)H-Index: 1
Last.Antonios G. Mikos (Rice University)H-Index: 121
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Abstract Current in vitro methods for assessing cancer biology and therapeutic response rely heavily on monolayer cell culture on hard, plastic surfaces that do not recapitulate essential elements of the tumor microenvironment. While a host of tumor models exist, most are not engineered to control the physical properties of the microenvironment and thus may not reflect the effects of mechanotransduction on tumor biology. Utilizing coaxial electrospinning, we developed three-dimensional (3D) tumo...
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#1Lauren E. HayduH-Index: 4
#2Serigne LoH-Index: 23
Last.Michael N. DaviesH-Index: 3
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#1Ruiping Wang (University of Texas MD Anderson Cancer Center)H-Index: 2
#2Shumei Song (University of Texas MD Anderson Cancer Center)H-Index: 17
Last.Linghua Wang (University of Texas MD Anderson Cancer Center)H-Index: 26
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Intra-tumoral heterogeneity (ITH) is the fundamental property of cancer, however, the origin of ITH remains poorly understood. Here we performed single-cell RNA sequencing of peritoneal carcinomatosis (PC) from 20 patients with advanced gastric adenocarcinoma (GAC), constructed a transcriptome map of 45,048 PC cells, determined the cell-of-origin of each tumor cell, and incisively explored ITH of PC tumor cells at single-cell resolution. The links between cell-of-origin and ITH was illustrated a...
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