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Andrew M. Courtwright
Hospital of the University of Pennsylvania
Health careIntensive care medicineLung transplantationEthics ConsultationMedicine
50Publications
9H-index
425Citations
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Publications 55
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Abstract To understand the challenges for thoracic transplantation and mechanical circulatory support during the current COVID-19 pandemic, we propose separating the effects of the pandemic into 5 distinct stages from a healthcare system perspective. We discuss how the classical ethical principles of utility, justice and efficiency may need to be adapted, and we give specific recommendations for thoracic transplantation and mechanical circulatory support centers to balance their clinical decisio...
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#1Ashwin S. Nathan (Leonard Davis Institute of Health Economics)H-Index: 8
#2Catherine Blebea (UPenn: University of Pennsylvania)
Last. Andrew M. Courtwright (HUP: Hospital of the University of Pennsylvania)H-Index: 9
view all 9 authors...
INTRODUCTION: One-year post-transplant survival is a significant quality measure for solid organ transplant programs in the United States. It is not known whether the use of this metric is associated with changes in life-sustaining clinical practices that would delay mortality for solid organ recipients until just beyond the one-year time point. METHODS: We compared trends in mortality in the time period immediately preceding the one-year post-transplant mark compared to the period immediately a...
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#1Julia I. Bandini (Brandeis University)
#2Andrew M. Courtwright (Harvard University)H-Index: 9
Last. Ellen M. Robinson (Harvard University)H-Index: 7
view all 8 authors...
Abstract Background The opioid epidemic has resulted in an increased number of patients with opioid use disorder (OUD) hospitalized for serious medical conditions. The intersection between hospital ethics consultation and the opioid crisis has not received significant attention. Objective The aim of this single center retrospective cohort study was to characterize ethics consult questions among inpatients with OUD. Results Between 1993-2017, OUD played a central role in the ethics consultation i...
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#1Andrew M. Courtwright (HUP: Hospital of the University of Pennsylvania)H-Index: 9
#2Severine CaoH-Index: 2
Last. Hilary J. Goldberg (Brigham and Women's Hospital)H-Index: 16
view all 9 authors...
Rationale: There is significant variation in approach to pre–lung transplant donor-specific antibodies (DSA), with some centers declining to cross any DSA. We implemented a protocol for transplanta...
1 CitationsSource
#1Andrew M. Courtwright (HUP: Hospital of the University of Pennsylvania)H-Index: 9
#2Anthony M. Lamattina (Brigham and Women's Hospital)H-Index: 3
Last. Souheil El-Chemaly (Brigham and Women's Hospital)H-Index: 19
view all 12 authors...
Hyaluronan (HA) is associated with innate immune response activation and may be a marker of allograft dysfunction in lung transplant recipients. This was a prospective, single center study comparing levels of bronchioalveolar lavage (BAL) and serum HA and the HA immobilizer LYVE-1 in lung transplant recipients with and without acute cellular rejection (ACR). Chronic lung allograft dysfunction (CLAD)-free survival was also evaluated based on HA and LYVE-1 levels. 78 recipients were enrolled with ...
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#1Anthony M. Lamattina (Brigham and Women's Hospital)H-Index: 3
#2Sergio Poli (Brigham and Women's Hospital)
Last. Souheil El-Chemaly (Brigham and Women's Hospital)H-Index: 19
view all 13 authors...
Endostatin is a naturally occurring collagen fragment with anti-angiogenic properties. We investigated the association between serum endostatin levels and DLCO in a cohort of patients with lymphangioleiomyomatosis (LAM). Associations of endostatin levels to clinical features of LAM were explored using logistic regression models. Endostatin levels were associated with DLCO and were higher in subjects with TSC-associated LAM compared to sporadic LAM. These data suggest that endostatin could be a p...
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#1Andrew M. Courtwright (Harvard University)H-Index: 9
#2Emily Rubin (Harvard University)H-Index: 9
Last. Hilary J. Goldberg (Brigham and Women's Hospital)H-Index: 16
view all 7 authors...
The lung allocation score system in the United States and several European countries gives more weight to risk of death without transplantation than to survival following transplantation. As a result, centers transplant sicker patients, leading to increased length of initial hospitalization. The care of patients who have accumulated functional deficits or additional organ dysfunction during their prolonged stay can be ethically complex. Disagreement occurs between the transplant team, patients a...
1 CitationsSource
#1Andrew M. Courtwright (HUP: Hospital of the University of Pennsylvania)H-Index: 9
#2Souheil El-Chemaly (Brigham and Women's Hospital)H-Index: 19
Telomeres are repetitive nucleotide sequences that cap linear chromosomes, thereby limiting progressive chromosomal shortening during cell replication. In conjunction with environmental factors, co...
2 CitationsSource
#1Andrew M. Courtwright (Harvard University)H-Index: 9
#2Emily Rubin (Harvard University)H-Index: 9
Last. Hilary J. Goldberg (Brigham and Women's Hospital)H-Index: 16
view all 7 authors...
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#1Joshua K. Cho (HUP: Hospital of the University of Pennsylvania)
#2Michael Acord (Children's Hospital of Philadelphia)H-Index: 4
Last. Andrew M. Courtwright (HUP: Hospital of the University of Pennsylvania)H-Index: 9
view all 6 authors...
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