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Leon P. McLean
University of Maryland, Baltimore
27Publications
9H-index
237Citations
Publications 27
Newest
#1Elisabeth Cole (University of Pittsburgh)H-Index: 2
#2Yash ShahH-Index: 5
Last.Nabeel Khan (UPenn: University of Pennsylvania)H-Index: 13
view all 5 authors...
Abstract Background The risk of developing colorectal cancer (CRC) in patients with chronic ulcerative colitis (UC) is increased. The aim of this study was to evaluate if patients who developed CRC in the setting of UC were undergoing guideline-recommended surveillance colonoscopies and to determine the impact of surveillance on the staging of CRC. Patients and Methods Data was obtained from the Veterans Affairs healthcare system to identify patients with UC and CRC. Stage 0 and I were considere...
3 CitationsSource
#1Leon P. McLean (UMB: University of Maryland, Baltimore)H-Index: 9
#2Raymond K. Cross (UMB: University of Maryland, Baltimore)H-Index: 22
ABSTRACTIntroduction: Vedolizumab is an anti-integrin approved for the treatment of Crohn’s disease and ulcerative colitis. By binding the α4β7-integrin heterodimer, vedolizumab blocks leukocyte translocation into gastrointestinal tissue.Areas covered: This review discusses the chemistry, pharmacologic properties, clinical efficacy, and safety of vedolizumab in ulcerative colitis. Other medications available for the treatment of ulcerative colitis are also discussed.Expert opinion: Vedolizumab i...
Source
#1Leon P. McLean (UMB: University of Maryland, Baltimore)H-Index: 9
#2Allen Smith (USDA: United States Department of Agriculture)H-Index: 17
Last.Terez Shea-Donohue (UMB: University of Maryland, Baltimore)H-Index: 34
view all 10 authors...
Despite increased appreciation for the role of nicotinic receptors in the modulation of and response to inflammation, the contribution of muscarinic receptors to mucosal homeostasis, clearance of enteric pathogens, and modulation of immune cell function remains relatively undefined. Uninfected and Nippostrongylus brasiliensis -infected wild-type and type 3 muscarinic receptor (M3R)-deficient ( Chrm3 −/− ) mice were studied to determine the contribution of M3R to mucosal homeostasis as well as ho...
11 CitationsSource
#1Leon P. McLean (UMB: University of Maryland, Baltimore)H-Index: 9
#2Raymond K. Cross (UMB: University of Maryland, Baltimore)H-Index: 22
ABSTRACTIntroduction: Anti-integrin therapy for the treatment of patients with Crohn’s disease is rapidly evolving. Two agents, natalizumab and vedolizumab, are approved by the United States Food and Drug Administration for the treatment of Crohn’s disease, with vedolizumab the primary anti-integrin used due to a more favorable safety profile. Several other anti-integrins are in various stages of development.Areas Covered: This review discusses the current state of anti-integrin therapy as well ...
11 CitationsSource
Source
#1Terez Shea-Donohue (UMB: University of Maryland, Baltimore)H-Index: 34
#2Rex Sun (UMB: University of Maryland, Baltimore)H-Index: 11
Last.Aiping Zhao (UMB: University of Maryland, Baltimore)H-Index: 22
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Abstract Protective immunity against enteric parasitic nematodes is dependent on IL-4, IL-13 activation of their exclusive transcription factor STAT6. The precise pathways by which enteric parasitic nematodes are recognized by the host is unclear, but elimination of this important interaction in developed nations is thought to contribute to the dysregulated immune responses that are a characteristic of autoimmune diseases. Nematode-derived products are involved in evading host defenses to promot...
9 CitationsSource
#1Leon P. McLean (UMB: University of Maryland, Baltimore)H-Index: 9
#2Allen Smith (USDA: United States Department of Agriculture)H-Index: 17
Last.Terez Shea-Donohue (UMB: University of Maryland, Baltimore)H-Index: 34
view all 11 authors...
Background The role of muscarinic receptors in mucosal homeostasis, response to enteric pathogens, and modulation of immune cell function is undefined.
9 CitationsSource
#1Nathalie H. Urrunaga (UMB: University of Maryland, Baltimore)H-Index: 6
#2Ravirajsinh N. Jadeja (Georgia Regents University)H-Index: 20
Last.Sandeep Khurana (Georgia Regents University)H-Index: 14
view all 10 authors...
The role of muscarinic receptor subtypes in modulating acute liver injury is unknown. We detected M1 muscarinic receptors (M1R) expression in human and murine hepatocytes, and investigated the consequences of M1R deficiency on acute liver injury in vivo and inhibiting M1R activation on hepatocyte injury in vitro. Age-matched wild-type (WT) and M1R-deficient (Chrm1−/−) male mice were injected intraperitoneally with 200 mg/kg acetaminophen (APAP) and euthanized 0, 2, 4, 16, 24 and 36 h later. Bioc...
15 CitationsSource
Source
#1Rex Sun (UMB: University of Maryland, Baltimore)H-Index: 11
#2Allen Smith (USDA: United States Department of Agriculture)H-Index: 17
Last.Terez Shea-Donohue (UMB: University of Maryland, Baltimore)H-Index: 34
view all 10 authors...
Local neutrophil influx occurs in response to enteric bacterial as well as nematode infection. Neutrophilic release of the serine protease, elastase (NE), is implicated in host defense as well as tissue injury. The aim of this study was to determine the contribution of elastase in host defense against enteric pathogens that induce a Th1/Th17 or a Th2 immune response. Elastase deficient (ELA1-/-) or C57BL/6 (WT) mice (n=5-7) were inoculated with Nippostrongylus brasiliensis (Nb) and studied 5 and...
1 Citations
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