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Hassan Ansari
Royan Institute
Induced pluripotent stem cellEmbryonic stem cellMolecular biologyBiologyCell biology
12Publications
5H-index
84Citations
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Publications 13
Newest
#1Anna Meyfour (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 2
#2Sara Pahlavan (Royan Institute)H-Index: 6
Last. Ghasem Hosseini Salekdeh (Macquarie University)H-Index: 39
view all 5 authors...
Despite the small number of Y chromosome genes, their adequate expression is required for regulation of transcription, translation, and protein stability in males, not just for sex determination. In addition to the role in male fertility, the Y chromosome has a significant role in the development and sexual dimorphism of healthy and disease phenotypes. We observed that KDM5D along with its X-counterpart, KDM5C, are up-regulated during the cardiac mesoderm stage of development. Down-regulation of...
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#1Sadaf Vahdat (UT: University of Tehran)H-Index: 4
#2Sara Pahlavan (Royan Institute)H-Index: 6
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 8 authors...
Cardiovascular progenitor cells (CPCs) derived from human pluripotent stem cells (hPSCs) are proposed to be invaluable cell sources for experimental and clinical studies. This wide range of applications necessitates large-scale production of CPCs in an in vitro culture system, which enables both expansion and maintenance of these cells. In this study, we aimed to develop a defined and efficient culture medium that uses signaling factors for large-scale expansion of early CPCs, called cardiogenic...
1 CitationsSource
#1Maryam Kay (TMU: Tarbiat Modares University)H-Index: 4
#2Bahram Mohammad Soltani (TMU: Tarbiat Modares University)H-Index: 10
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
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Background WNT and TGFβ signaling pathways play critical regulatory roles in cardiomyocyte fate determination and differentiation. MiRNAs are also known to regulate different biological processes and signaling pathways. Here, we intended to find candidate miRNAs that are involved in cardiac differentiation through regulation of WNT and TGFβ signaling pathways.
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#1Fahimeh Varzideh (Royan Institute)H-Index: 3
#2Sara Pahlavan (Royan Institute)H-Index: 6
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 10 authors...
Abstract Human cardiomyocytes (CM) differentiated from pluripotent stem cells (PSCs) are relatively immature when generated in two-dimensional (2D) in vitro cultures, which limits their biomedical applications. Here, we devised a strategy to enhance maturation of human CM in vitro by assembly of three-dimensional (3D) cardiac organoids (CO) containing human embryonic stem cell-derived cardiac progenitor cells (hESC-CPCs), endothelial cells (ECs), and mesenchymal stem cells (MSCs). In contrast to...
5 CitationsSource
#1Parisa Ghiasi (TMU: Tarbiat Modares University)H-Index: 3
#2Saman Hosseinkhani (TMU: Tarbiat Modares University)H-Index: 28
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 7 authors...
2 CitationsSource
#1Sarah RajabiH-Index: 4
#2Sara PahlavanH-Index: 6
Last. Hossein BaharvandH-Index: 44
view all 11 authors...
Abstract Bioengineering of whole hearts using human embryonic stem cells (hESCs)-derived cardiovascular progenitor cells (CPCs) and natural matrices is a promising approach to overcome organ donor shortage threatening millions of patients awaiting for heart transplantation. Here, we developed a novel strategy for generation of heart constructs by repopulating engineered decellularized rat hearts using hESCs-derived CPCs. Careful expansion of CPCs in a scalable stirred-suspension bioreactor combi...
8 CitationsSource
1 CitationsSource
Despite evidence for sex-specific cardiovascular physiology and pathophysiology, the biological basis for this dimorphism remains to be explored. Apart from hormonal factors, gender-related characteristics may reside in the function of sex chromosomes during cardiac development. In this study, we investigated the differential expression of the male-specific region of the Y chromosome (MSY) genes and their X counterparts during cardiac differentiation of human embryonic stem cells (hESC). We obse...
6 CitationsSource
#1Sara Pahlavan (Academic Center for Education, Culture and Research)H-Index: 6
#2Marziyeh Shalchi Tousi (Academic Center for Education, Culture and Research)H-Index: 1
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 7 authors...
Cardiac arrhythmias are major life-threatening conditions. The landmark discovery of induced pluripotent stem cells has provided a promising in vitro system for modeling hereditary cardiac arrhythmias as well as drug development and toxicity testing. Nowadays, nutraceuticals are frequently used as supplements for cardiovascular therapy. Here we studied the cardiac effects of hawthorn (Crataegus pentagyna) leaf extract using cardiomyocytes (CMs) differentiated from healthy human embryonic stem ce...
5 CitationsSource
#1Sara Pahlavan (Royan Institute)H-Index: 6
#2Mahdi Ayyari (TMU: Tarbiat Modares University)H-Index: 6
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 6 authors...
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