Steven R. Smith
Translational Research Institute
EndocrinologyAdipose tissueInsulin resistanceDiabetes mellitusMedicine
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Publications 29
#1Adeline Divoux (Translational Research Institute)H-Index: 1
#2Katalin Sándor (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
Last. Steven R. Smith (Translational Research Institute)H-Index: 8
view all 9 authors...
#1Léa GarneauH-Index: 1
Last. Céline AguerH-Index: 13
view all 6 authors...
Exercise and physical activity levels influence myokine release from skeletal muscle and contribute to circulating concentrations. Indeed, many myokines, including interleukin (IL-) 6, IL-15, secreted protein acidic rich in cysteine (SPARC) and fibroblast growth factor (FGF) 21 are higher in the circulation after an exercise bout. Since these peptides modulate muscle metabolism and can also be targeted towards other tissues to induce adaptations to energy demand, they are of great interest regar...
#1Stephen J. Gardell (Translational Research Institute)H-Index: 5
#2Meghan E. Hopf (Translational Research Institute)H-Index: 1
Last. Anthony B. Pinkerton (DI: Discovery Institute)H-Index: 9
view all 18 authors...
Pharmacological strategies that boost intracellular NAD+ are highly coveted for their therapeutic potential. One approach is activation of nicotinamide phosphoribosyltransferase (NAMPT) to increase production of nicotinamide mononucleotide (NMN), the predominant NAD+ precursor in mammalian cells. A high-throughput screen for NAMPT activators and hit-to-lead campaign yielded SBI-797812, a compound that is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these in...
1 CitationsSource
#1Adeline Divoux (Translational Research Institute)H-Index: 2
#2Katalin Sándor (DI: Discovery Institute)H-Index: 4
Last. Steven R. Smith (Translational Research Institute)H-Index: 8
view all 8 authors...
Increased lower body fat is associated with reduced cardiometabolic risk. The molecular basis for depot-specific differences in gluteofemoral (GF) compared with abdominal (A) subcutaneous adipocyte function is poorly understood. In the current report, we used a combination of Assay for Transposase-Accessible Chromatin followed by sequencing (ATAC-seq), RNA-seq, and chromatin immunoprecipitation (ChIP)-qPCR analyses that provide evidence that depot-specific gene expression patterns are associated...
#1Natalie A. Stephens (Translational Research Institute)H-Index: 2
#2Bram Brouwers (Translational Research Institute)H-Index: 7
Last. Lauren M. Sparks (Translational Research Institute)H-Index: 18
view all 10 authors...
OBJECTIVE Some individuals with type 2 diabetes do not reap metabolic benefits from exercise training, yet the underlying mechanisms of training response variation are largely unexplored. We classified individuals with type 2 diabetes ( n = 17) as nonresponders ( n = 6) or responders ( n = 11) based on changes in phosphocreatine (PCr) recovery rate after 10 weeks of aerobic training. We aimed to determine whether the training response variation in PCr recovery rate was marked by distinct epigeno...
3 CitationsSource
#1Erin A. Bohula (Harvard University)H-Index: 18
#2Stephen D. Wiviott (Harvard University)H-Index: 67
Last. Benjamin M. Scirica (Harvard University)H-Index: 47
view all 26 authors...
Abstract Background Lorcaserin, a selective serotonin 2C receptor agonist that modulates appetite, has proven efficacy for weight management in overweight or obese patients. The cardiovascular safety and efficacy of lorcaserin are undefined. Methods We randomly assigned 12,000 overweight or obese patients with atherosclerotic cardiovascular disease or multiple cardiovascular risk factors to receive either lorcaserin (10 mg twice daily) or placebo. The primary safety outcome of major cardiovascul...
50 CitationsSource
#1Rushita A. BagchiH-Index: 10
#2Bradley S. FergusonH-Index: 12
Last. Timothy A. McKinseyH-Index: 57
view all 17 authors...
4 CitationsSource
#1Bram Brouwers (Translational Research Institute)H-Index: 7
#2Natalie A. Stephens (Translational Research Institute)H-Index: 2
Last. Steven R. Smith (Translational Research Institute)H-Index: 8
view all 11 authors...
Mice overexpressing NAMPT in skeletal muscle (NamptTg mice) develop higher exercise endurance and maximal aerobic capacity (VO2max) following voluntary exercise training compared to wild-type (WT) mice. Here, we aimed to investigate the mechanisms underlying by determining skeletal muscle mitochondrial respiratory capacity in NamptTg and WT mice. Body weight and body composition, tissue weight (gastrocnemius, quadriceps, soleus, heart, liver and epidydimal white adipose tissue), skeletal muscle ...
#1Sheila R. Costford (Pennington Biomedical Research Center)H-Index: 13
#2Bram Brouwers (Translational Research Institute)H-Index: 7
Last. Steven R. Smith (Pennington Biomedical Research Center)H-Index: 8
view all 18 authors...
Abstract Objective Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD+), an essential co-substrate regulating a myriad of signaling pathways. We produced a mouse that overexpressed NAMPT in skeletal muscle (NamptTg) and hypothesized that NamptTg mice would have increased oxidative capacity, endurance performance, and mitochondrial gene expression, and would be rescued from metabolic abnormalities...
6 CitationsSource
#1Maria F. Pino (Translational Research Institute)H-Index: 3
#2A Divoux (Translational Research Institute)H-Index: 1
Last. Lauren M. Sparks (Translational Research Institute)H-Index: 18
view all 5 authors...
Despite successful preclinical testing, 85% of early clinical trials for novel drugs fail. Most futilities originate from molecular mechanisms of the drug(s) tested. It is critically important to develop validated human cell-based model systems in which animal-based research can be translated in order to complement the preclinical in vivo findings prior to implementation of a clinical trial. Obesity is associated with reduced circulating levels of Orexin-A (OX-A) in humans. OX-A increases thermo...
8 CitationsSource