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Steven R. Smith
Translational Research Institute
319Publications
71H-index
18.6kCitations
Publications 319
Newest
#1Stephen J. Gardell (Translational Research Institute)H-Index: 4
#2Meghan E. Hopf (Translational Research Institute)H-Index: 1
Last.Chris Petucci (DI: Discovery Institute)H-Index: 3
view all 18 authors...
Pharmacological strategies that boost intracellular NAD+ are highly coveted for their therapeutic potential. One approach is activation of nicotinamide phosphoribosyltransferase (NAMPT) to increase production of nicotinamide mononucleotide (NMN), the predominant NAD+ precursor in mammalian cells. A high-throughput screen for NAMPT activators and hit-to-lead campaign yielded SBI-797812, a compound that is structurally similar to active-site directed NAMPT inhibitors and blocks binding of these in...
#1Adeline Divoux (Translational Research Institute)H-Index: 2
#2Katalin Sandor (DI: Discovery Institute)
Last.Steven R. Smith (Translational Research Institute)H-Index: 71
view all 8 authors...
Background Increased lower body fat is associated with reduced cardiometabolic risk. The molecular basis for depot-specific differences in gluteofemoral (GF) compared with abdominal (A) subcutaneous adipocyte function is poorly understood. In the current report, we used a combination of Assay for Transposase-Accessible Chromatin followed by sequencing (ATAC-seq), RNA-seq, and chromatin immunoprecipitation (ChIP)-qPCR analyses that provide evidence that depot-specific gene expression patterns are...
#1Natalie A. Stephens (Translational Research Institute)H-Index: 2
#2Bram Brouwers (Translational Research Institute)H-Index: 6
Last.Lauren M. Sparks (Translational Research Institute)H-Index: 19
view all 10 authors...
OBJECTIVE Some individuals with type 2 diabetes do not reap metabolic benefits from exercise training, yet the underlying mechanisms of training response variation are largely unexplored. We classified individuals with type 2 diabetes ( n = 17) as nonresponders ( n = 6) or responders ( n = 11) based on changes in phosphocreatine (PCr) recovery rate after 10 weeks of aerobic training. We aimed to determine whether the training response variation in PCr recovery rate was marked by distinct epigeno...
#1Erin A. Bohula (Harvard University)H-Index: 17
#2Stephen D. Wiviott (Harvard University)H-Index: 67
Last.Andrzej BudajH-Index: 76
view all 26 authors...
Abstract Background Lorcaserin, a selective serotonin 2C receptor agonist that modulates appetite, has proven efficacy for weight management in overweight or obese patients. The cardiovascular safety and efficacy of lorcaserin are undefined. Methods We randomly assigned 12,000 overweight or obese patients with atherosclerotic cardiovascular disease or multiple cardiovascular risk factors to receive either lorcaserin (10 mg twice daily) or placebo. The primary safety outcome of major cardiovascul...
#1Rushita Bagchi (CU: University of Colorado Boulder)H-Index: 9
#2Bradley S. Ferguson (CU: University of Colorado Boulder)H-Index: 11
Last.Kunhua Song (CU: University of Colorado Boulder)H-Index: 10
view all 17 authors...
Little is known about the biological function of histone deacetylase 11 (HDAC11), which is the lone class IV HDAC. Here, we demonstrate that deletion of HDAC11 in mice stimulates brown adipose tissue (BAT) formation and beiging of white adipose tissue (WAT). Consequently, HDAC11-deficient mice exhibit dramatically enhanced thermogenic potential and, in response to high fat feeding, attenuated obesity, insulin resistance, and hepatic steatosis. Ex vivo and cell-based assays revealed that HDAC11 c...
#1Bram Brouwers (Translational Research Institute)H-Index: 6
#2Natalie A. Stephens (Translational Research Institute)H-Index: 2
Last.Lauren M. Sparks (Translational Research Institute)H-Index: 19
view all 11 authors...
Mice overexpressing NAMPT in skeletal muscle (NamptTg mice) develop higher exercise endurance and maximal aerobic capacity (VO2max) following voluntary exercise training compared to wild-type (WT) mice. Here, we aimed to investigate the mechanisms underlying by determining skeletal muscle mitochondrial respiratory capacity in NamptTg and WT mice. Body weight and body composition, tissue weight (gastrocnemius, quadriceps, soleus, heart, liver and epidydimal white adipose tissue), skeletal muscle ...
#1Sheila R. Costford (Pennington Biomedical Research Center)H-Index: 11
#2Bram Brouwers (Translational Research Institute)H-Index: 6
Last.Hui Xie (Pennington Biomedical Research Center)H-Index: 20
view all 18 authors...
Abstract Objective Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD + ), an essential co-substrate regulating a myriad of signaling pathways. We produced a mouse that overexpressed NAMPT in skeletal muscle (NamptTg) and hypothesized that NamptTg mice would have increased oxidative capacity, endurance performance, and mitochondrial gene expression, and would be rescued from metabolic abnormaliti...
Investigating the effects of Orexin-A on thermogenesis in human deep neck brown adipose tissue
#1Adeline Divoux (Translational Research Institute)H-Index: 2
#2Hui Xie (Translational Research Institute)H-Index: 3
Last.Steven R. Smith (Translational Research Institute)H-Index: 71
view all 8 authors...
Objective Lower body fat is associated with diminishing cardiometabolic risk. Physiological differences between gluteofemoral and abdominal subcutaneous adipocyte functions are known, but the molecular basis for depot differences in adipocyte function is poorly understood. The objective of this study was to identify depot differences in microRNA (miRNA) expression in human abdominal and gluteofemoral subcutaneous adipose tissues and their implication in gene regulation. Methods Abdominal and glu...
#1Ryan D. Welch (SLU: Saint Louis University)H-Index: 2
#2Chun Guo (SLU: Saint Louis University)H-Index: 1
Last.Zhang J (SLU: Saint Louis University)H-Index: 63
view all 12 authors...
Abstract Objective The loss of skeletal muscle mass and strength are a central feature of traumatic injury and degenerative myopathies. Unfortunately, pharmacological interventions typically fail to stem the long-term decline in quality of life. Reduced Rev-Erb-mediated gene suppression in cultured C2C12 myoblasts has been shown to stimulate myoblast differentiation. Yet the mechanisms that allow Rev-Erb to pleiotropically inhibit muscle differentiation are not well understood. In this study, we...
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