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Soon-Sen Leow
Malaysian Palm Oil Board
EndocrinologyGene expressionMicroarrayBiochemistryBiology
12Publications
7H-index
132Citations
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Publications 11
Newest
#1Soon-Sen Leow (Malaysian Palm Oil Board)H-Index: 7
#2Alice Luu (Brandeis University)H-Index: 1
Last. Ravigadevi Sambanthamurthi (Malaysian Palm Oil Board)H-Index: 16
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Abstract Palm fruit juice (PFJ) containing oil palm phenolics is obtained as a by-product from oil palm ( Elaeis guineensis ) fruit milling. It contains shikimic acid, soluble fibre and various phenolic acids including p -hydroxybenzoic acid and three caffeoylshikimic acid isomers. PFJ has also demonstrated beneficial health properties in various biological models. Increasing concentrations of PFJ and different PFJ fractions were used to assess growth dynamics and possible anti-ageing properties...
2 CitationsSource
#1Soon-Sen LeowH-Index: 7
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#1Soon-Sen Leow (Malaysian Palm Oil Board)H-Index: 7
#2Julia Bolsinger (Brandeis University)H-Index: 4
Last. Ravigadevi Sambanthamurthi (Malaysian Palm Oil Board)H-Index: 16
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Background The Nile rat (NR, Arvicanthis niloticus) is a model of carbohydrate-induced type 2 diabetes mellitus (T2DM) and the metabolic syndrome. A previous study found that palm fruit juice (PFJ) delayed or prevented diabetes and in some cases even reversed its early stages in young NRs. However, the molecular mechanisms by which PFJ exerts these anti-diabetic effects are unknown. In this study, the transcriptomic effects of PFJ were studied in young male NRs, using microarray gene expression ...
9 CitationsSource
#1Che Anishas Che Idris (UKM: National University of Malaysia)H-Index: 2
#2Tilakavati Karupaiah (UKM: National University of Malaysia)H-Index: 9
Last. Ravigadevi Sambanthamurthi (Malaysian Palm Oil Board)H-Index: 16
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Abstract The protective effects of oil palm vitamin E and phenolics against atherosclerosis, either singly or in combination, were studied in an atherogenic rabbit model. Rabbits were either fed atherogenic diet only (CTR), or atherogenic diet with vitamin E (VIT E), or atherogenic diet with oil palm phenolics (OPP), or atherogenic diet with both vitamin E and oil palm phenolics (VIT E + OPP). Results from lipid profile and antioxidant analyses were not significantly different between groups (p ...
14 CitationsSource
#1Soon-Sen LeowH-Index: 7
#2Shamala Devi Sekaran (UM: University of Malaya)H-Index: 32
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AbstractObjectivesPhenolics are important phytochemicals which have positive effects on chronic diseases, including neurodegenerative ailments. The oil palm (Elaeis guineensis) is a rich source of water-soluble phenolics. This study was carried out to discover the effects of administering oil palm phenolics (OPP) to mice, with the aim of identifying whether these compounds possess significant neuroprotective properties.MethodsOPP was given to BALB/c mice on a normal diet as fluids for 6 weeks wh...
15 CitationsSource
#1Soon-Sen Leow (Malaysian Palm Oil Board)H-Index: 7
#2Shamala Devi Sekaran (UM: University of Malaya)H-Index: 32
Last. Ravigadevi Sambanthamurthi (Malaysian Palm Oil Board)H-Index: 16
view all 5 authors...
Background Water-soluble phenolics from the oil palm possess significant biological properties.
14 CitationsSource
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Background/Aim: Plant phenolics can inhibit, retard or reverse carcinogenesis, and may thus help prevent or treat cancer. Oil palm phenolics (OPP) previously showed anti-tumour activities in vivo via a cytostatic mechanism at 1,500 ppm gallic acid equivalent. Here, we report other possible molecular mechanisms by which this extract attenuates cancer, especially those concerning the immune response. Methods: We subcutaneously injected J558 myeloma cells in BALB/c mice and supplemented OPP orally ...
4 CitationsSource
#1Ravigadevi Sambanthamurthi (Malaysian Palm Oil Board)H-Index: 16
#2YewAi Tan (Malaysian Palm Oil Board)H-Index: 8
Last. Mohd Basri Wahid (Malaysian Palm Oil Board)H-Index: 11
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Waste from agricultural products represents a disposal liability, which needs to be addressed. Palm oil is the most widely traded edible oil globally, and its production generates 85 million tons of aqueous by-products annually. This aqueous stream is rich in phenolic antioxidants, which were investigated for their composition and potential in vitro biological activity. We have identified three isomers of caffeoylshikimic acid as major components of oil palm phenolics (OPP). The 2,2-diphenyl-1-p...
34 CitationsSource
#1Ravigadevi Sambanthamurthi (Malaysian Palm Oil Board)H-Index: 16
#2YewAi Tan (Malaysian Palm Oil Board)H-Index: 8
Last. Mohd Basri Wahid (Malaysian Palm Oil Board)H-Index: 11
view all 13 authors...
It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbit...
20 CitationsSource
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