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Kak K. Yeung
VU University Medical Center
33Publications
8H-index
365Citations
Publications 33
Newest
Published on May 2, 2019in Scientific Reports4.01
Natalija Bogunovic2
Estimated H-index: 2
(VUmc: VU University Medical Center),
Jorn P. Meekel1
Estimated H-index: 1
(VUmc: VU University Medical Center)
+ 3 AuthorsKak K. Yeung8
Estimated H-index: 8
(VUmc: VU University Medical Center)
Ruptured abdominal aortic aneurysms (AAA) are associated with overall mortality rates up to 90%. Despite extensive research, mechanisms leading to AAA formation and advancement are still poorly understood. Smooth muscle cells (SMC) are predominant in the aortic medial layer and maintain the wall structure. Apoptosis of SMC is a well-known phenomenon in the pathophysiology of AAA. However, remaining SMC function is less extensively studied. The aim of this study is to assess the in vitro contract...
Published on May 1, 2019in European Journal of Vascular and Endovascular Surgery3.64
Harm P. Ebben2
Estimated H-index: 2
,
V. Jongkind5
Estimated H-index: 5
+ 2 AuthorsKak K. Yeung8
Estimated H-index: 8
Objective Catheter directed thrombolysis (CDT) for peripheral arterial occlusions is a well established alternative to thrombo-embolectomy in patients with (sub)acute limb ischaemia. However, protocols are heterogeneous and need optimisation to improve results and lower bleeding risks. The objective was to review the results and outcomes of different CDT protocols for patients with peripheral arterial occlusions. Data sources Electronic information sources (MEDLINE, Embase, Cochrane) and referen...
Published on Feb 1, 2019in Journal of Endovascular Therapy2.99
Theodorus G. van Schaik (VUmc: VU University Medical Center), Jorn P. Meekel1
Estimated H-index: 1
(VUmc: VU University Medical Center)
+ 6 AuthorsKak K. Yeung8
Estimated H-index: 8
(VUmc: VU University Medical Center)
Purpose: To investigate in an in vitro model if secondary endobag filling can reduce gutter size during chimney endovascular aneurysm sealing (chEVAS). Materials and Methods: Nellix EVAS systems were deployed in 2 silicone juxtarenal aneurysm models with suprarenal aortic diameters of 19 and 24 mm. Four configurations were tested: EVAS with 6-mm balloon-expandable (BE) or self-expanding (SE) chimney grafts (CGs) in the renal branches of both models. Balloons were inflated simultaneously in the C...
Published on Jan 1, 2019in EJVES Short Reports
Jorn P. Meekel1
Estimated H-index: 1
(VUmc: VU University Medical Center),
Theodorus G. van Schaik (VUmc: VU University Medical Center)+ 2 AuthorsArjan W.J. Hoksbergen7
Estimated H-index: 7
(VUmc: VU University Medical Center)
Introduction Ruptured abdominal aortic aneurysms (AAAs) are known to be associated with high fatal outcomes. Giant AAAs are often defined as having a maximum diameter over 13 cm. Large AAAs over 8 cm have demonstrated a yearly rupture rate of 30–50%, which explains the rarity of giant AAAs. Endovascular repair of ruptured AAAs (rAAAs) is increasingly advocated because of the shorter hospital stay and fewer post-operative complications. Nonetheless, outcomes regarding mortality and cost-effective...
Published on Dec 1, 2018in Scientific Reports4.01
Jorn P. Meekel1
Estimated H-index: 1
(VUmc: VU University Medical Center),
Menno E. Groeneveld2
Estimated H-index: 2
(VUmc: VU University Medical Center)
+ 12 AuthorsArno M. Wiersema3
Estimated H-index: 3
The pathophysiology of aortic aneurysms (AA) is far from being understood. One reason for this lack of understanding is basic research being constrained to fixated cells or isolated cell cultures, by which cell-to-cell and cell-to-matrix communications are missed. We present a new, in vitro method for extended preservation of aortic wall sections to study pathophysiological processes. Intraoperatively harvested, live aortic specimens were cut into 150 μm sections and cultured. Viability was quan...
Published on Nov 1, 2018in European Journal of Vascular and Endovascular Surgery3.64
Marina Dias-Neto4
Estimated H-index: 4
(University of Porto),
Jorn P. Meekel (VU: VU University Amsterdam)+ 7 AuthorsKak K. Yeung8
Estimated H-index: 8
Objectives: Perivascular adipose tissue (PVAT) is currently seen as a paracrine organ that produces vasoactive substances, including inflammatory agents, which may have an impact on the vasculature. In this study PVAT density was quantified in patients with an aortic aneurysm and compared with those with a non-dilated aorta. Since chronic inflammation, as the pathway to medial thinning, is a hallmark of abdominal aortic aneurysms (AAAs), it was hypothesised that PVAT density is higher in AAA pat...
Published on Sep 1, 2018in Human Mutation4.45
Eline Overwater1
Estimated H-index: 1
(UvA: University of Amsterdam),
Luisa Marsili1
Estimated H-index: 1
(VUmc: VU University Medical Center)
+ 18 AuthorsMarlies Kempers13
Estimated H-index: 13
(Radboud University Nijmegen)
Simultaneous analysis of multiple genes using next-generation sequencing (NGS) technology has become widely available. Copy-number variations (CNVs) in disease-associated genes have emerged as a cause for several hereditary disorders. CNVs are, however, not routinely detected using NGS analysis. The aim of this study was to assess the diagnostic yield and the prevalence of CNVs using our panel of Hereditary Thoracic Aortic Disease (H-TAD)-associated genes. Eight hundred ten patients suspected of...
Published on Jul 3, 2018in Journal of the American Heart Association4.66
Menno E. Groeneveld2
Estimated H-index: 2
(VUmc: VU University Medical Center),
Jorn P. Meekel1
Estimated H-index: 1
(VUmc: VU University Medical Center)
+ 5 AuthorsKak K. Yeung8
Estimated H-index: 8
(VUmc: VU University Medical Center)
Background The natural course of abdominal aortic aneurysms (AAA) is growth and rupture if left untreated. Numerous markers have been investigated; however, none are broadly acknowledged. Our aim w...
Published on Jan 1, 2018in Cardiovascular Pathology1.76
Menno E. Groeneveld2
Estimated H-index: 2
(VUmc: VU University Medical Center),
Natalija Bogunovic2
Estimated H-index: 2
(VUmc: VU University Medical Center)
+ 5 AuthorsKak K. Yeung8
Estimated H-index: 8
(VUmc: VU University Medical Center)
Abstract Background Marfan syndrome (MFS), a congenital connective tissue disorder leading to aortic aneurysm development, is caused by fibrillin-1 ( FBN1 ) gene mutations. Transforming growth factor beta (TGF-β) might play a role in the pathogenesis. It is still a matter of discussion if and how TGF-β up-regulates the intracellular downstream pathway, although TGF-β receptor 3 ( TGFBR3 or Betaglycan) is thought to be involved. We aimed to elucidate the role of TGFBR3 protein in TGF-β signaling ...
Published on Nov 1, 2017in Journal of Vascular Surgery3.24
Theodorus G. van Schaik1
Estimated H-index: 1
,
Kak K. Yeung8
Estimated H-index: 8
+ 74 AuthorsD.E. Grobbee1
Estimated H-index: 1
Abstract Objective Randomized trials have shown an initial survival benefit of endovascular over conventional open abdominal aortic aneurysm repair but no long-term difference up to 6 years after repair. Longer follow-up may be required to demonstrate the cumulative negative impact on survival of higher reintervention rates associated with endovascular repair. Methods We updated the results of the Dutch Randomized Endovascular Aneurysm Management (DREAM) trial, a multicenter, randomized controll...
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