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Amanda Jager
Radboud University Nijmegen
13Publications
3H-index
57Citations
Publications 13
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#1Amanda Jager (Radboud University Nijmegen)H-Index: 3
#2Sarita A. Dam (Radboud University Nijmegen)
Last.Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
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Abstract Learning from feedback is one of the key mechanisms within cognitive flexibility, which is needed to react swiftly to constantly changing environments. The motivation to change behavior is highly dependent on the expectancy of positive (reward) or negative (punishment) feedback. Individuals with conduct disorder (CD) with high callous unemotional traits show decreased sensitivity to negative feedback and increased reward seeking. Previous studies have modelled traits associated with CD ...
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#1Sarita Dam (Radboud University Nijmegen)H-Index: 1
#2Amanda Jager (Radboud University Nijmegen)H-Index: 3
Last.Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
view all 6 authors...
Abstract Dysregulation of executive function (EF) involves alterations in cognitive flexibility / control and is underscored by learning impairments in neurodevelopmental disorders. Here, we examine cognitive inflexibility in BALB/cJ mice (a mouse model showing diminished sociability, increased anxiety and inattentive behaviour) and closely related “reference” BALB/cByJ mice. We used an appetitive extinction paradigm to investigate if cognitive flexibility measures are different between learning...
1 CitationsSource
Anterior cingulate cortex (ACC) and midcingulate cortex (MCC) have been implicated in the regulation of aggressive behaviour. For instance, patients with conduct disorder (CD) show increased levels of aggression accompanied by changes in ACC and MCC volume. However, accounts of ACC/MCC changes in CD patients have been conflicting, likely due to the heterogeneity of the studied populations. Here, we address these discrepancies by studying volumetric changes of ACC/MCC in the BALB/cJ mouse, a mode...
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#1Joana VianaH-Index: 9
#2Georgina MansellH-Index: 2
Last.Jonathan MillH-Index: 60
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#1F. MogaveroH-Index: 1
#2Amanda JagerH-Index: 3
Last.J.C. GlennonH-Index: 8
view all 5 authors...
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#1Amanda Jager (Radboud University Nijmegen)H-Index: 3
#2Dorien A. Maas (Radboud University Nijmegen)H-Index: 1
Last.Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
view all 6 authors...
Abstract Aggressive behavior is often core or comorbid to psychiatric and neurodegenerative disorders. Transgenic animal models are commonly used to study the neurobiological mechanisms underlying aggressive phenotypes and have led to new insights into aggression. This systematic review critically evaluates the available literature on transgenic animal models tested for aggression with the resident-intruder test. By combining the available literature on this topic, we sought to highlight effecti...
2 CitationsSource
A balanced integration of emotional and cognitive information is essential for flexible behaviour, which involves the anterior cingulate cortex (ACC) and the midcingulate cortex (MCC) [1]. Both clinical and preclinical researchers have been interested in studying the role of ACC and MCC in health and disease but preclinical rodent studies so far have suffered from a severe misconception: The definition of ACC/MCC used for rodents is not homologous to the human definition of ACC/MCC. Due to this,...
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#1Amanda Jager (Radboud University Nijmegen)H-Index: 3
#2Houshang Amiri (Radboud University Nijmegen)H-Index: 10
Last.Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
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Abstract Reduced top-down control by cortical areas is assumed to underlie pathological forms of aggression. While the precise underlying molecular mechanisms are still elusive, it seems that balancing the excitatory and inhibitory tones of cortical brain areas has a role in aggression control. The molecular mechanisms underpinning aggression control were examined in the BALB/cJ mouse model. First, these mice were extensively phenotyped for aggression and anxiety in comparison to BALB/cByJ contr...
6 CitationsSource
#1Floriana Mogavero (UvA: University of Amsterdam)H-Index: 1
#2Amanda Jager (Radboud University Nijmegen)H-Index: 3
Last.Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
view all 3 authors...
Abstract Attention deficit/hyperactivity disorder (ADHD) is frequently associated with comorbid aggression and sleep disturbances. The sleep/wake cycle is under the control of the circadian system which is moderated by clock genes. Clock genes can regulate the transcription of monoamine oxidase A, which is involved in the degradation of monoamines. Disturbances in monoamine interaction with clock genes in those with monoamine gene polymorphisms may regulate susceptibility of ADHD and comorbid ag...
3 CitationsSource
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