Jonas Schroeder
Boston Children's Hospital
Publications 5
#1Patricia Hafner (Boston Children's Hospital)H-Index: 10
#2Ulrike Bonati (Boston Children's Hospital)H-Index: 8
Last.Dirk Fischer (Boston Children's Hospital)H-Index: 20
view all 18 authors...
Importance Nitric oxide precursors, such as the amino acidl-arginine and the biguanide antidiabetic drug metformin, have been associated with metabolism and muscle function in patients with Duchenne muscular dystrophy (DMD). The treatment of DMD remains an unmet medical need. Objective To evaluate the benefits and harms of a combination ofl-citrulline and metformin treatment among patients with DMD. Design, Setting, and Participants A single-center randomized double-blind placebo-controlled para...
#1Patricia HafnerH-Index: 10
#2Ulrike BonatiH-Index: 8
Last.Dirk FischerH-Index: 20
view all 18 authors...
Introduction: Quantitative magnetic resonance imaging (MRI) methods to quantify muscle tissue fat content are increasingly used in the evaluation of patients with inherited neuromuscular disorders. Recently, these techniques gained importance to detect disease progression and possible treatment responses. In this study, two widely used fat quantification MRI sequences (two- and three- point Dixon) were applied to assess the reproducibility and reliability of the techniques. Methods: For this cli...
#1Simone Schmidt (University of Basel)H-Index: 2
#2Patricia Hafner (Boston Children's Hospital)H-Index: 10
Last.Ulrike Bonati (University of Basel)H-Index: 8
view all 20 authors...
The development of new therapeutic agents for the treatment of Duchenne muscular dystrophy has put a focus on defining outcome measures most sensitive to capture treatment effects. This cross-sectional analysis investigates the relation between validated clinical assessments such as the 6-minute walk test, motor function measure and quantitative muscle MRI of thigh muscles in ambulant Duchenne muscular dystrophy patients, aged 6.5 to 10.8 years (mean 8.2, SD 1.1). Quantitative muscle MRI include...
4 CitationsSource
#1Ulrike Bonati (University of Basel)H-Index: 8
#2Patricia Hafner (University of Basel)H-Index: 10
Last.Dirk Fischer (University of Basel)H-Index: 20
view all 16 authors...
Abstract In muscular dystrophies quantitative muscle MRI (qMRI) detects disease progression more sensitively than clinical scores. This prospective one year observational study compared qMRI with clinical scores in Duchenne muscular dystrophy (DMD) to investigate if qMRI can serve as a surrogate outcome measure in clinical trials. In 20 DMD patients the motor function measure (MFM) total and subscores (D1–D3) were done for physical examination, and the fat fraction (MFF) of thigh muscle qMRI was...
39 CitationsSource