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Jian Meng
Xiamen University
2Publications
1H-index
6Citations
Publications 2
Newest
Published on Aug 1, 2018in Biological Psychiatry11.50
Dongdong Zhao1
Estimated H-index: 1
(Ha Tai: Xiamen University),
Jian Meng1
Estimated H-index: 1
(Ha Tai: Xiamen University)
+ 21 AuthorsHao Sun3
Estimated H-index: 3
(Ha Tai: Xiamen University)
Abstract Background Although synaptic impairment is a prerequisite to cognitive deficiencies in Alzheimer’s disease (AD), mechanisms underlying the dysregulation of essential synaptic scaffolding components and their integrity remain elusive. RPS23RG1 is a newly identified protein implicated in AD. However, the physiological function of RPS23RG1 has yet to be determined. Methods We investigated the role of RPS23RG1 in maintaining synaptic structure and function in cell cultures and in Rps23rg1 k...
Published on Aug 1, 2017in Molecular Neurobiology4.59
Qiuyang Zheng6
Estimated H-index: 6
(Ha Tai: Xiamen University),
Xiaoyuan Zheng3
Estimated H-index: 3
(Ha Tai: Xiamen University)
+ 11 AuthorsJian Meng1
Estimated H-index: 1
(Ha Tai: Xiamen University)
TMEM59L is a newly identified brain-specific membrane-anchored protein with unknown functions. Herein we found that both TMEM59L and its homolog, TMEM59, are localized in Golgi and endosomes. However, in contrast to a ubiquitous and relatively stable temporal expression of TMEM59, TMEM59L expression was limited in neurons and increased during development. We also found that both TMEM59L and TMEM59 interacted with ATG5 and ATG16L1, and that overexpression of them triggered cell autophagy. However...
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