Jian Meng
Xiamen University
Downregulation and upregulationNeuroprotectionProgrammed cell deathMorris water navigation taskSynaptic plasticity
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Publications 2
#1Dongdong Zhao (Ha Tai: Xiamen University)H-Index: 1
#2Jian Meng (Ha Tai: Xiamen University)H-Index: 2
Last. Yun Wu Zhang (Ha Tai: Xiamen University)H-Index: 23
view all 24 authors...
Abstract Background Although synaptic impairment is a prerequisite to cognitive deficiencies in Alzheimer’s disease (AD), mechanisms underlying the dysregulation of essential synaptic scaffolding components and their integrity remain elusive. RPS23RG1 is a newly identified protein implicated in AD. However, the physiological function of RPS23RG1 has yet to be determined. Methods We investigated the role of RPS23RG1 in maintaining synaptic structure and function in cell cultures and in Rps23rg1 k...
2 CitationsSource
#1Qiuyang Zheng (Ha Tai: Xiamen University)H-Index: 7
#2Xiaoyuan Zheng (Ha Tai: Xiamen University)H-Index: 3
Last. Yun Wu Zhang (Ha Tai: Xiamen University)H-Index: 23
view all 14 authors...
TMEM59L is a newly identified brain-specific membrane-anchored protein with unknown functions. Herein we found that both TMEM59L and its homolog, TMEM59, are localized in Golgi and endosomes. However, in contrast to a ubiquitous and relatively stable temporal expression of TMEM59, TMEM59L expression was limited in neurons and increased during development. We also found that both TMEM59L and TMEM59 interacted with ATG5 and ATG16L1, and that overexpression of them triggered cell autophagy. However...
17 CitationsSource