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Mikhail Korzinkin
Johns Hopkins University
14Publications
9H-index
276Citations
Publications 12
Newest
#2Pamela Leal-Rojas (UFRO: University of La Frontera)H-Index: 6
Last.Aditi ChatterjeeH-Index: 28
view all 24 authors...
Gallbladder cancer (GBC) is a rare malignancy, associated with poor disease prognosis with a 5-year survival of only 20%. This has been attributed to late presentation of the disease, lack of early diagnostic markers and limited efficacy of therapeutic interventions. Elucidation of molecular events in GBC can contribute to better management of the disease by aiding in the identification of therapeutic targets. To identify aberrantly activated signaling events in GBC, tandem mass tag-based quanti...
1 CitationsSource
#1Michael D. WestH-Index: 32
#2Ivan LabatH-Index: 4
Last.Alex Zhavoronkov (Johns Hopkins University)H-Index: 26
view all 23 authors...
// Michael D. West 1 , Ivan Labat 1 , Hal Sternberg 1 , Dana Larocca 1 , Igor Nasonkin 2 , Karen B. Chapman 3 , Ratnesh Singh 2 , Eugene Makarev 4 , Alex Aliper 4 , Andrey Kazennov 4, 5 , Andrey Alekseenko 4, 10 , Nikolai Shuvalov 4, 5 , Evgenia Cheskidova 4, 5 , Aleksandr Alekseev 4, 5 , Artem Artemov 4 , Evgeny Putin 4, 6 , Polina Mamoshina 4 , Nikita Pryanichnikov 4 , Jacob Larocca 1 , Karen Copeland 7 , Evgeny Izumchenko 8 , Mikhail Korzinkin 4 and Alex Zhavoronkov 4, 9 1 AgeX Therapeutics, ...
10 CitationsSource
#1Nicolas Borisov (Kurchatov Institute)H-Index: 8
#2Maria SuntsovaH-Index: 9
Last.Anton Buzdin (Kurchatov Institute)H-Index: 9
view all 21 authors...
ABSTRACTHigh throughput technologies opened a new era in biomedicine by enabling massive analysis of gene expression at both RNA and protein levels. Unfortunately, expression data obtained in different experiments are often poorly compatible, even for the same biologic samples. Here, using experimental and bioinformatic investigation of major experimental platforms, we show that aggregation of gene expression data at the level of molecular pathways helps to diminish cross- and intra-platform bia...
17 CitationsSource
#1Evgeny PutinH-Index: 8
#2Polina MamoshinaH-Index: 7
Last.Alex ZhavoronkovH-Index: 26
view all 10 authors...
One of the major impediments in human aging research is the absence of a comprehensive and actionable set of biomarkers that may be targeted and measured to track the effectiveness of therapeutic interventions. In this study, we designed a modular ensemble of 21 deep neural networks (DNNs) of varying depth, structure and optimization to predict human chronological age using a basic blood test. To train the DNNs, we used over 60,000 samples from common blood biochemistry and cell count tests from...
74 CitationsSource
#2Mikhail KorzinkinH-Index: 9
Last.Anton Buzdin (Kurchatov Institute)H-Index: 9
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ABSTRACTMicroRNAs (miRs) are short noncoding RNA molecules that regulate expression of target mRNAs. Many published sources provide information about miRs and their targets. However, bioinformatic tools elucidating higher level impact of the established total miR profiles, are still largely missing. Recently, we developed a method termed OncoFinder enabling quantification of the activities of intracellular molecular pathways basing on gene expression data. Here we propose a new technique, MiRImp...
13 CitationsSource
#1Denis ShepelinH-Index: 3
#2Mikhail KorzinkinH-Index: 9
Last.Anton BuzdinH-Index: 26
view all 13 authors...
// Denis Shepelin 1, 2 , Mikhail Korzinkin 1, 3 , Anna Vanyushina 4 , Alexander Aliper 4 , Nicolas Borisov 3, 5 , Raif Vasilov 5 , Nikolay Zhukov 3, 6 , Dmitry Sokov 7 , Vladimir Prassolov 8 , Nurshat Gaifullin 9 , Alex Zhavoronkov 10 , Bhupinder Bhullar 11 , Anton Buzdin 1, 4, 5 1 Pathway Pharmaceuticals, Wan Chai, Hong Kong, Hong Kong SAR 2 Group for Genomic Analysis of Cell Signaling Systems, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia 3 First Oncology Research and...
13 CitationsSource
#1Nicolas BorisovH-Index: 8
#2Maria SuntsovaH-Index: 9
Last.Anton BuzdinH-Index: 9
view all 11 authors...
#1Nikolay M. BorisovH-Index: 14
Last.Anton BuzdinH-Index: 26
view all 9 authors...
// Nikolay M. Borisov 1, 2 , Nadezhda V. Terekhanova 1, 3 , Alexander M. Aliper 1, 3 , Larisa S. Venkova 1, 2 , Philip Yu Smirnov 1, 2 , Sergey Roumiantsev 1, 3 , Mikhail B. Korzinkin 1, 2 , Alex A. Zhavoronkov 1, 3, 4 , Anton A. Buzdin 1, 3, 4 1 Pathway Pharmaceuticals, Wan Chai, Hong Kong, Hong Kong SAR 2 Laboratory of Systems Biology, A.I. Burnasyan Federal Medical Biophysical Center, Moscow, 123182, Russia 3 Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hema...
43 CitationsSource
#1Ksenia LezhninaH-Index: 7
#2Olga KovalchukH-Index: 10
Last.Anton BuzdinH-Index: 26
view all 14 authors...
// Ksenia Lezhnina 1,2 , Olga Kovalchuk 3,4 , Alexander A. Zhavoronkov, 2,5,6 , Mikhail B. Korzinkin 1 , Anastasia A. Zabolotneva 7 , Peter V. Shegay 8 , Dmitry G. Sokov 9 , Nurshat M. Gaifullin 10,11 , Igor G. Rusakov 8 , Alexander M. Aliper 1,2 , Sergey A. Roumiantsev 2 , Boris Y. Alekseev 8 , Nikolay M. Borisov 12 and Anton A. Buzdin 1,2,7 1 Pathway Pharmaceuticals, Wan Chai, Hong Kong, Hong Kong SAR 2 Laboratory of Bioinformatics, D. Rogachyov Federal Research Center of Pediatric Hematology,...
23 CitationsSource
#1Anton Buzdin (RAS: Russian Academy of Sciences)H-Index: 26
#2Alex ZhavoronkovH-Index: 26
Last.Nikolay M. BorisovH-Index: 14
view all 8 authors...
The diversity of the installed sequencing and microarray equipment make it increasingly difficult to compare and analyze the gene expression datasets obtained using the different methods. Many applications requiring high-quality and low error rates can not make use of available data using traditional analytical approaches. Recently, we proposed a new concept of signalome-wide analysis of functional changes in the intracellular pathways termed OncoFinder, a bioinformatic tool for quantitative est...
34 CitationsSource
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