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Defang Ouyang
University of Macau
SolubilityChemistryDrug deliveryChromatographyMolecular dynamics
57Publications
12H-index
546Citations
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Publications 63
Newest
#1Nikhila MiriyalaH-Index: 2
#2Daniel KirbyH-Index: 18
Last. Haitao YeH-Index: 17
view all 7 authors...
Given the great potential of porous carrier-based drug delivery for stabilising the amorphous form of drugs and enhancing dissolution profiles, this work is focussed on the synthesis and application of carbon onion or onion-like carbon (OLC) as a porous carrier for oral amorphous drug delivery, using paracetamol (PA) and ibuprofen (IBU) as model drugs. Annealing of nanodiamonds at 1100 °C produced OLC with a diamond core that exhibited low cytotoxicity on Caco-2 cells. Solution adsorption follow...
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#1Yuan HeH-Index: 1
#2Zhuyifan Ye (UM: University of Macau)H-Index: 2
Last. Defang OuyangH-Index: 12
view all 8 authors...
Abstract Nanocrystals have exhibited great advantage for enhancing the dissolution rate of water insoluble drugs due to the reduced size to nanoscale. However, current pharmaceutical approaches for nanocrystals formulation development highly depend on the expert experience and trial-and-error attempts which remain time and resource consuming. In this research, we utilized machine learning techniques to predict the particle size and polydispersity index (PDI) of nanocrystals. Firstly, 910 nanocry...
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#1Haoshi Gao (UM: University of Macau)H-Index: 1
#2Zhuyifan Ye (UM: University of Macau)
Last. Defang Ouyang (UM: University of Macau)H-Index: 12
view all 7 authors...
Abstract This research aims to predict the complexation performance of phospholipid complex by machine learning methods. 341 drugs/ phospholipid complex formulations were collected from the literature. The datasets were trained by the lightGBM method. To validate the prediction modeling, berberine (BBR) was used as the model drug to form the complex with phospholipid. Molecular dynamics simulation was used to investigate the molecular mechanism for self-aggregation of BBR in solution and BBR-pho...
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#1Ming-Yue Wu (UM: University of Macau)H-Index: 4
#2Le Liu (Southern Medical University)
Last. Zhuohua Zhang (CSU: Central South University)H-Index: 15
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ABSTRACTNRBF2, a regulatory subunit of the ATG14-BECN1/Beclin 1-PIK3C3/VPS34 complex, positively regulates macroautophagy/autophagy. In this study, we report that NRBF2 is required for the clearanc...
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Magnetization measurements and time-of-flight neutron powder-diffraction studies on the high-temperature (300--980 K) magnetism and crystal structure (321--1200 K) of a pulverized YCrO_3single crystal have been performed. Temperature-dependent inverse magnetic susceptibility coincides with a piecewise linear function with five regimes, with which we fit a Curie-Weiss law and calculate the frustration factor f The fit results indicate a formation of magnetic polarons between 300 and 540 K a...
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#1Qianqian Zhao (UM: University of Macau)H-Index: 3
#2Haoshi Gao (UM: University of Macau)H-Index: 1
Last. Defang Ouyang (UM: University of Macau)H-Index: 12
view all 7 authors...
Abstract Traditional experimental methods have their own limitations to obtain a deep understanding about the molecular mechanism of drug-cyclodextrin (CD) complexes. Thus, present research investigated the molecular interactions between poorly water-soluble drug Ketoprofen (KTP) and six commonly used CDs by combined experimental and modeling methods. Experimental characterizations of prepared KTP-CD complexes observed the crystalline changes and hydrogen bonding formations of KTP. The molecular...
1 CitationsSource
#1Tianhe Huang (UM: University of Macau)H-Index: 1
#2Qianqian Zhao (UM: University of Macau)H-Index: 3
Last. Defang Ouyang (UM: University of Macau)H-Index: 12
view all 4 authors...
Abstract Cyclodextrin complexation is a wise strategy to enhance aqueous solubility of water-insoluble drugs. However, the aggregation mechanism of drug-cyclodextrin complexes is still unclear. This research aimed to investigate the molecular aggregation mechanism of glipizide/cyclodextrin complexation by the combination of experimental and modeling methods. Binding free energies between glipizide and cyclodextrins from modeling calculations were higher than those by the phase solubility diagram...
1 CitationsSource
#1Run Han (UM: University of Macau)H-Index: 2
#2Hui Xiong (ECUST: East China University of Science and Technology)H-Index: 3
Last. Defang Ouyang (UM: University of Macau)H-Index: 12
view all 10 authors...
Abstract Amorphous solid dispersion (SD) is an effective solubilization technique for water-insoluble drugs. However, physical stability issue of solid dispersions still heavily hindered the development of this technique. Traditional stability experiments need to be tested at least three to six months, which is time-consuming and unpredictable. In this research, a novel prediction model for physical stability of solid dispersion formulations was developed by machine learning techniques. 646 stab...
2 CitationsSource
#1Run Han (UM: University of Macau)H-Index: 2
#2Tianhe Huang (UM: University of Macau)H-Index: 1
Last. Defang Ouyang (UM: University of Macau)H-Index: 12
view all 9 authors...
With the increase concern of solubilization for insoluble drug, ternary solid dispersion (SD) formulations developed more rapidly than binary systems. However, rational formulation design of ternary systems and their dissolution molecular mechanism were still under development. Current research aimed to develop the effective ternary formulations and investigate their molecular mechanism by integrated experimental and modeling techniques. Glipizide (GLI) was selected as the model drug and PEG was...
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#1Qiang Li (ECUST: East China University of Science and Technology)H-Index: 1
#2Qianqian Zhao (UM: University of Macau)
Last. Fuzheng Ren (ECUST: East China University of Science and Technology)H-Index: 4
view all 8 authors...
Abstract Molecular interactions between drug and polymeric carriers are believed to be the key for high drug loading and better physical stability of micro-particles. However, molecular interactions between drug and polymer are still difficult to investigate using only experimental tools. In this study, high-loaded glipizide (GLP)/hydroxypropyl methylcellulose acetate succinate (HPMCAS) (1/1 w/w) micro-particles were prepared using an in situ pH-dependent solubility method. Molecular interaction...
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