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Seong-Ok Lee
Seoul National University
Molecular biologyMHC class ISignal peptide peptidaseProtein disulfide-isomeraseBiology
2Publications
2H-index
62Citations
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Publications 2
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#1Min-Ji Seo (SNU: Seoul National University)H-Index: 3
#2Seong-Ok Lee (SNU: Seoul National University)H-Index: 2
Last. Kwangseog Ahn (SNU: Seoul National University)H-Index: 25
view all 10 authors...
The innate immune system detects viral nucleic acids and induces type I interferon (IFN) responses. The RNA- and DNA-sensing pathways converge on the protein kinase TANK-binding kinase 1 (TBK1) and the transcription factor IFN-regulatory factor 3 (IRF3). Activation of the IFN signaling pathway is known to trigger the redistribution of key signaling molecules to punctate perinuclear structures, but the mediators of this spatiotemporal regulation have yet to be defined. Here we identify butyrophil...
9 CitationsSource
#1Seong-Ok Lee (SNU: Seoul National University)H-Index: 2
#2Kwangmin Cho (SNU: Seoul National University)H-Index: 8
Last. Kwangseog Ahn (SNU: Seoul National University)H-Index: 25
view all 6 authors...
The human cytomegalovirus glycoprotein US2 induces dislocation of MHC class I heavy chains from the endoplasmic reticulum (ER) into the cytosol and targets them for proteasomal degradation. Signal peptide peptidase (SPP) has been shown to be integral for US2-induced dislocation of MHC class I heavy chains although its mechanism of action remains poorly understood. Here, we show that knockdown of protein disulphide isomerase (PDI) by RNA-mediated interference inhibited the degradation of MHC clas...
53 CitationsSource
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