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Lee H. Harrison
University of Pittsburgh
EpidemiologyVirologyImmunologyPopulationMedicine
362Publications
85H-index
32.1kCitations
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Publications 378
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#1Praveen Kumar (University of Pittsburgh)
#2Alexander J. Sundermann (University of Pittsburgh)H-Index: 3
Last. Mark S. Roberts (University of Pittsburgh)H-Index: 49
view all 7 authors...
BACKGROUND: Whole genome sequencing (WGS) surveillance and electronic health record data mining have the potential to greatly enhance the identification and control of hospital outbreaks. The objective was to develop methods for examining economic value of a WGS surveillance-based infection prevention (IP) program compared to Standard of Care (SoC). METHODS: The economic value of a WGS surveillance-based IP program was assessed from a hospital's perspective using historical outbreaks from 2011-2...
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#1Daniel R. Evans (University of Pittsburgh)H-Index: 2
#2Marissa P. Griffith (University of Pittsburgh)H-Index: 1
Last. Daria Van Tyne (University of Pittsburgh)H-Index: 1
view all 10 authors...
Multidrug-resistant bacteria pose a serious health threat, especially in hospitals. Horizontal gene transfer (HGT) of mobile genetic elements (MGEs) facilitates the spread of antibiotic resistance, virulence, and environmental persistence genes between nosocomial pathogens. We screened the genomes of 2173 bacterial isolates from healthcare-associated infections from a single hospital over 18 months, and identified identical nucleotide regions in bacteria belonging to distinct genera. To further ...
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#1Daniel R. Evans (University of Pittsburgh)H-Index: 2
#2Marissa P. Griffith (University of Pittsburgh)H-Index: 1
Last. Daria Van Tyne (University of Pittsburgh)H-Index: 1
view all 10 authors...
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#1Sharon TsayH-Index: 5
#2Yi MuH-Index: 17
Last. Sasha HarbH-Index: 1
view all 30 authors...
BACKGROUND: Candidemia is a common healthcare-associated bloodstream infection with high morbidity and mortality. There are no current estimates of candidemia burden in the United States. METHODS: In 2017, the Centers for Disease Control and Prevention (CDC) conducted active population-based surveillance for candidemia through the Emerging Infections Program (EIP) in 45 counties in nine states encompassing ~17 million persons (5% of the national population). Laboratories serving the catchment ar...
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#1Ahmed Babiker (Emory University)H-Index: 2
#2Daniel R. Evans (University of Pittsburgh)H-Index: 2
Last. Ryan K. Shields (University of Pittsburgh)H-Index: 31
view all 11 authors...
Carbapenem-non-susceptible Citrobacter spp. (CNSC) are increasingly recognized as healthcare-associated pathogens. Information regarding their clinical epidemiology, genetic diversity, and mechanisms of carbapenem resistance is lacking. We examined microbiology records of adult patients at the University of Pittsburgh Medical Center (UMPC) Presbyterian Hospital (PUH) from 2000-2018 for CNSC, as defined by ertapenem non-susceptibility. Over this timeframe, the proportion of CNSC increased from 4%...
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#1Angela R. Wateska (University of Pittsburgh)H-Index: 16
#2Mary Patricia Nowalk (University of Pittsburgh)H-Index: 36
Last. Kenneth J. Smith (University of Pittsburgh)H-Index: 27
view all 7 authors...
BACKGROUND/OBJECTIVES: Recently revised vaccination recommendations for US adults, aged 65 years and older, include both 23-valent pneumococcal polysaccharide vaccine (PPSV23) and 13-valent pneumococcal conjugate vaccine (PCV13), with PCV13 now recommended for immunocompetent older people based on shared decision making. The public health impact and cost-effectiveness of this recommendation or of pneumococcal vaccine uptake improvement interventions are unclear. DESIGN: Markov decision analysis....
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#1Lesley McGee (CDC: Centers for Disease Control and Prevention)H-Index: 24
#2Sopio Chochua (CDC: Centers for Disease Control and Prevention)H-Index: 10
Last. Lee H. Harrison (Johns Hopkins University)H-Index: 85
view all 17 authors...
BACKGROUND: Group B Streptococcus (GBS) is a leading cause of neonatal sepsis and meningitis and an important cause of invasive infections in pregnant and nonpregnant adults. Vaccines targeting capsule polysaccharides and common proteins are under development. METHODS: Using whole genome sequencing (WGS), a validated bioinformatics pipeline, and targeted antimicrobial susceptibility testing, we characterized 6,340 invasive GBS recovered during 2015-2017 through population-based Active Bacterial ...
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#1Tolulope Adebanjo (National Center for Immunization and Respiratory Diseases)H-Index: 1
#2Tracy PondoH-Index: 12
Last. Lee H. Harrison (Johns Hopkins University)H-Index: 85
view all 19 authors...
BACKGROUND: Most countries use 3-dose pneumococcal conjugate vaccine (PCV) schedules; a 4-dose (3 primary and 1 booster) schedule is licensed for US infants. We evaluated the invasive pneumococcal disease (IPD) breakthrough infection incidence in children receiving 2 vs 3 primary PCV doses with and without booster doses (2 + 1 vs 3 + 1; 2 + 0 vs 3 + 0). METHODS: We used 2001–2016 Active Bacterial Core surveillance data to identify breakthrough infections (vaccine-type IPD in children receiving ≥...
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#1Angela R. Wateska (University of Pittsburgh)H-Index: 16
#2Mary Patricia Nowalk (University of Pittsburgh)H-Index: 36
Last. Kenneth J. Smith (University of Pittsburgh)H-Index: 27
view all 7 authors...
In US adults aged < 65 years, pneumococcal vaccination is recommended when high-risk conditions are present, but vaccine uptake is low. Additionally, there are race-based differences in illness risk and vaccination rates. The cost-effectiveness of programs to improve vaccine uptake or of alternative vaccination policies to increase protection is unclear. A decision analysis compared, in US black and general population cohorts aged 50 years, the public health impact and cost-effectiveness of pneu...
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We describe 2 human cases of infection with a new Neisseria species (putatively N. brasiliensis), 1 of which involved bacteremia. Genomic analyses found that both isolates were distinct strains of the same species, were closely related to N. iguanae, and contained a capsule synthesis operon similar to N. meningitidis.
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