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Lee H. Harrison
University of Pittsburgh
354Publications
83H-index
31.9kCitations
Publications 354
Newest
#1Nicholas Usher (USU: Uniformed Services University of the Health Sciences)H-Index: 1
#2Suyoung Chang (FDA: Food and Drug Administration)
Last.Naomi E. Aronson (USU: Uniformed Services University of the Health Sciences)H-Index: 20
view all 7 authors...
Importance The BCG vaccine is currently the only approved tuberculosis vaccine and is widely administered worldwide, usually during infancy. Previous studies found increased rates of lymphoma and leukemia in BCG-vaccinated populations. Objective To determine whether BCG vaccination was associated with cancer rates in a secondary analysis of a BCG vaccine trial. Design, Setting, and Participants Retrospective review (60-year follow-up) of a clinical trial in which participants were assigned to th...
#1Jane W. MarshH-Index: 20
Last.Ryan K. ShieldsH-Index: 30
view all 10 authors...
ABSTRACT Carbapenem-resistant Klebsiella pneumoniae (CRKP) strains belonging to sequence type 258 (ST258) are frequent causes of hospital-associated outbreaks and are a major contributor to the spread of carbapenemases. This genetic lineage emerged several decades ago and remains a major global health care challenge. In this study, genomic epidemiology was used to investigate the emergence, evolution, and persistence of ST258 carbapenem-resistant K. pneumoniae outbreak-causing lineages at a larg...
#1Angela R. Wateska (University of Pittsburgh)H-Index: 16
#2Mary Patricia Nowalk (University of Pittsburgh)H-Index: 36
Last.Kenneth J. Smith (University of Pittsburgh)H-Index: 26
view all 7 authors...
In US adults aged < 65 years, pneumococcal vaccination is recommended when high-risk conditions are present, but vaccine uptake is low. Additionally, there are race-based differences in illness risk and vaccination rates. The cost-effectiveness of programs to improve vaccine uptake or of alternative vaccination policies to increase protection is unclear. A decision analysis compared, in US black and general population cohorts aged 50 years, the public health impact and cost-effectiveness of pneu...
#1Mary Patricia Nowalk (University of Pittsburgh)H-Index: 36
#2Angela R. Wateska (University of Pittsburgh)H-Index: 16
Last.Kenneth J. Smith (University of Pittsburgh)H-Index: 26
view all 7 authors...
Abstract Background Racial disparities in U.S. adult pneumococcal vaccination rates persist despite reduced barriers to access. Consequently, racial and ethnic minorities experience pneumococcal disease at higher rates than whites. This study examined prevalence of high-risk conditions and pneumococcal hospitalizations among U.S. black and non-black populations aged ≥50 years. Methods National Health Interview Survey, National Center for Health Statistics and National Inpatient Sample data were ...
#1Lucy A. McNamara (National Center for Immunization and Respiratory Diseases)H-Index: 14
#2Caelin C. Potts (National Center for Immunization and Respiratory Diseases)H-Index: 2
view all 10 authors...
#1Angela R. Wateska (University of Pittsburgh)H-Index: 16
#2Mary Patricia Nowalk (University of Pittsburgh)H-Index: 36
Last.Kenneth J. Smith (University of Pittsburgh)H-Index: 26
view all 7 authors...
ABSTRACTIn the U.S., pneumococcal polysaccharide vaccine (PPSV23) uptake among high-risk adults aged <65 years is consistently low and improvement is needed. One barrier to improved vaccine coverage is the complexity of the adult vaccination schedule. This exploratory analysis compared the cost-effectiveness of strategies to increase pneumococcal vaccine uptake in high-risk adults aged 50–64 years. We used a Markov model to compare strategies for non-immunocompromised 50–64 year olds: 1) current...
#1Louise Francois Watkins (CDC: Centers for Disease Control and Prevention)H-Index: 5
#2Lesley McGee (CDC: Centers for Disease Control and Prevention)H-Index: 22
Last.Joan Baumbach (New Mexico Department of Health)H-Index: 26
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Importance Group B Streptococcus (GBS) is an important cause of invasive bacterial disease. Previous studies have shown a substantial and increasing burden of GBS infections among nonpregnant adults, particularly older adults and those with underlying medical conditions. Objective To update trends of invasive GBS disease among US adults using population-based surveillance data. Design, Setting, and Participants In this population-based surveillance study, a case was defined as isolation of GBS f...
Abstract Objectives The antimicrobial resistance (AMR) crisis represents a serious threat to public health and has resulted in concentrated efforts to accelerate development of rapid molecular diagnostics for AMR. In combination with publicly-available web-based AMR databases, whole genome sequencing (WGS) offers the capacity for rapid detection of antibiotic resistance genes. Here we studied the concordance between WGS-based resistance prediction and phenotypic susceptibility testing results fo...
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