Henrik Wolff
Finnish Institute of Occupational Health
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Publications 118
#1Sabina Halappanavar (Health Canada)H-Index: 24
#2Sybille van den Brule (UCL: Université catholique de Louvain)H-Index: 15
Last. Henrik Wolff (Finnish Institute of Occupational Health)H-Index: 31
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Toxicity testing and regulation of advanced materials at the nanoscale, i.e. nanosafety, is challenged by the growing number of nanomaterials and their property variants requiring assessment for potential human health impacts. The existing animal-reliant toxicity testing tools are onerous in terms of time and resources and are less and less in line with the international effort to reduce animal experiments. Thus, there is a need for faster, cheaper, sensitive and effective animal alternatives th...
2 CitationsSource
#1Juuso PaajanenH-Index: 1
#2Sanna LaaksonenH-Index: 2
Last. Henrik WolffH-Index: 31
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#1Juuso Paajanen (UH: University of Helsinki)H-Index: 1
#2Sanna Laaksonen (UH: University of Helsinki)H-Index: 2
Last. Mikko I. Mäyränpää (UH: University of Helsinki)H-Index: 23
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Abstract Diffuse malignant mesothelioma (DMM) of the pleura is a rare and aggressive disease, where the long-term survival (LTS) rate is low. The epithelioid subtype is the most prevalent form of DMM with the best prognosis. In order to study prognostic histopathologic factors associated with extended survival in epithelioid DMM, we examined 43 tumors from patients with survival over five years (long-term survivals [LTS]) and compared the findings with 84 tumors from a reference group with avera...
#2Anders Brostrøm (DTU: Technical University of Denmark)H-Index: 2
Last. Ulla Vogel (DTU: Technical University of Denmark)H-Index: 64
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Little is known about the exposure levels and adverse health effects of occupational exposure to airplane emissions. Diesel exhaust particles are classified as carcinogenic to humans and jet engines produce potentially similar soot particles. Here, we evaluated the potential occupational exposure risk by analyzing particles from a non-commercial airfield and from the apron of a commercial airport. Toxicity of the collected particles was evaluated alongside NIST standard reference diesel exhaust ...
#1Kukka Aimonen (Finnish Institute of Occupational Health)H-Index: 3
Last. Hannu Norppa (Finnish Institute of Occupational Health)H-Index: 56
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#1Laurent Gaté (Institut national de recherche et de sécurité)H-Index: 8
Last. Frédéric Cosnier (Institut national de recherche et de sécurité)H-Index: 8
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Abstract Multi-walled carbon nanotubes (MWCNTs), which vary in length, diameter, functionalization and specific surface area, are used in diverse industrial processes. Since these nanomaterials have a high aspect ratio and are biopersistant in the lung, there is a need for a rapid identification of their potential health hazard. We assessed in Sprague-Dawley rats the pulmonary toxicity of two pristine MWCNTs (the “long and thick” NM-401 and the “short and thin” NM-403) following either intratrac...
2 CitationsSource
#1Eeva Kettunen (Finnish Institute of Occupational Health)H-Index: 17
#2Sauli Savukoski (Finnish Institute of Occupational Health)H-Index: 2
Last. Henrik Wolff (Finnish Institute of Occupational Health)H-Index: 31
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Deletion of the CDKN2A locus is centrally involved in the development of several malignancies. In malignant pleural mesothelioma (MPM), it is one of the most frequently reported genomic alteration. MPM is strongly associated with a patients’ asbestos exposure. However, the status of CDKN2A and the expression of the corresponding protein, p16, in relation to MPM patient’s asbestos exposure is poorly known. Copy number alterations in 2p16, 9q33.1 and 19p13 have earlier been shown to accumulate in ...
#1Piia Karisola (UH: University of Helsinki)H-Index: 19
#2Alina Suomalainen (UH: University of Helsinki)H-Index: 2
Last. Harri Alenius (KI: Karolinska Institutet)H-Index: 54
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: Multi-walled carbon nanotubes (MWCNT) are widely used nanomaterials that cause pulmonary toxicity upon inhalation. The physicochemical properties of MWCNT vary greatly, which makes general safety evaluation challenging to conduct. Identification of the toxicity-inducing physicochemical properties of MWCNT is therefore of great importance. We have evaluated histological changes in lung tissue 1 year after a single intratracheal instillation of 11 well-characterized MWCNT in female C57BL/6N BomT...
9 CitationsSource
#1Niels HadrupH-Index: 17
Last. Ulla Vogel (DTU: Technical University of Denmark)H-Index: 64
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Abstract We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE NFC, 2–20 μm in length, 2–15 nm in width, 2) AS (−COOH), carboxylated, 0.5–10 μm in length, 4–10 nm in width, containing the biocide BIM MC4901 and 3) BIOCID FINE NFC: as (1) but containing BIM MC4901. FINE NFC administration increased neutrophil influx in BAL and induced...
4 CitationsSource