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Phillip J. Hendrickson
University of Southern California
17Publications
5H-index
62Citations
Publications 17
Newest
#1Gene J. Yu (SC: University of Southern California)H-Index: 5
#2Phillip J. Hendrickson (SC: University of Southern California)H-Index: 5
Last.Theodore W. Berger (SC: University of Southern California)H-Index: 50
view all 4 authors...
Interest in the hippocampus has generated vast amounts of experimental data describing hippocampal properties, including anatomical, morphological, biophysical, and synaptic transmission levels of analysis. However, this wealth of structural and functional detail has not guaranteed insight into higher levels of system operation.
Source
Aug 1, 2016 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
#1Phillip J. Hendrickson (SC: University of Southern California)H-Index: 5
#2Clayton S. Bingham (SC: University of Southern California)H-Index: 2
Last.Theodore W. Berger (SC: University of Southern California)H-Index: 50
view all 4 authors...
In order to accurately model the pattern of activation due to electrical stimulation of the hippocampus, a multi-scale computational approach is necessary. At the system level, the Admittance Method (ADM) is used to calculate the extracellular voltages created by a stimulating electrode. At the network and cellular levels, a large-scale multi-compartmental neuron network is used to calculate cellular activation. This paper presents a bi-directional communication paradigm between the NEURON model...
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#1Phillip J. Hendrickson (SC: University of Southern California)H-Index: 5
#2Gene J. Yu (SC: University of Southern California)H-Index: 5
Last.Theodore W. Berger (SC: University of Southern California)H-Index: 50
view all 4 authors...
Goal: This paper describes a million-plus granule cell compartmental model of the rat hippocampal dentate gyrus, including excitatory, perforant path input from the entorhinal cortex, and feedforward and feedback inhibitory input from dentate interneurons. Methods: The model includes experimentally determined morphological and biophysical properties of granule cells, together with glutamatergic AMPA-like EPSP and GABAergic GABAA-like IPSP synaptic excitatory and inhibitory inputs, respectively. ...
15 CitationsSource
#1Phillip J. Hendrickson (SC: University of Southern California)H-Index: 5
#2Gene J. Yu (SC: University of Southern California)H-Index: 5
Last.Theodore W. Berger (SC: University of Southern California)H-Index: 50
view all 4 authors...
This paper reports on findings from a million-cell granule cell model of the rat dentate gyrus that was used to explore the contributions of local interneuronal and associational circuits to network-level activity. The model contains experimentally derived morphological parameters for granule cells, which each contain approximately 200 compartments, and biophysical parameters for granule cells, basket cells, and mossy cells that were based both on electrophysiological data and previously publish...
11 CitationsSource
Aug 1, 2015 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
#1Gene J. Yu (SC: University of Southern California)H-Index: 5
#2Phillip J. Hendrickson (SC: University of Southern California)H-Index: 5
Last.Theodore W. Berger (SC: University of Southern California)H-Index: 50
view all 4 authors...
The correlation due to different topographies was characterized in a large-scale, biologically-realistic, computational model of the rat hippocampus using a spatio-temporal correlation analysis. The effect of the topographical projection between the following subregions of the hippocampus was investigated: the entorhinal to dentate projection, the entorhinal to CA3 projection, and the mossy fiber to CA3 projection. Through this work, analysis was performed on the individual and combined effects ...
2 CitationsSource
Aug 1, 2015 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
#1Phillip J. Hendrickson (SC: University of Southern California)H-Index: 5
#2Gene J. Yu (SC: University of Southern California)H-Index: 5
Last.Theodore W. Berger (SC: University of Southern California)H-Index: 50
view all 4 authors...
This paper describes a million-plus granule cell compartmental model of the rat hippocampal dentate gyrus, including excitatory, perforant path input from the entorhinal cortex, and feedforward and feedback inhibitory input from dentate interneurons. The model includes experimentally determined morphological and biophysical properties of granule cells, together with glutamatergic AMPA-like EPSP and GABAergic GABAA-like IPSP synaptic excitatory and inhibitory inputs, respectively. Each granule ce...
1 CitationsSource
Aug 1, 2015 in EMBC (International Conference of the IEEE Engineering in Medicine and Biology Society)
#1Andrew Gilbert (UofU: University of Utah)H-Index: 1
#2Kyle Loizos (UofU: University of Utah)H-Index: 2
Last.Theodore W. Berger (SC: University of Southern California)H-Index: 50
view all 6 authors...
Hippocampal prosthetic devices have been developed to bridge the gap between functioning portions of the hippocampus, in order to restore lost memory functionality in those suffering from brain injury or diseases. One approach taken in recent neuroprosthetic design is to use a multi-input, multi-output device that reads data from the CA3 in the hippocampus and electrically stimulates the CA1 in an attempt to mimic the appropriate firing pattern that would occur naturally between the two areas. H...
Source
#1Andy Gilbert (UofU: University of Utah)
#2Kyle Loizos (UofU: University of Utah)H-Index: 2
Last.Ted Berger (SC: University of Southern California)
view all 6 authors...
The hippocampus is associated with consolidating short-term memory into long-term memory. Therefore, damage to the hippocampus can result in neurological conditions such as Alzheimer's, dementia, and other diseases that affect memory. One way of helping patients affected by these conditions is to create a neural prosthesis that replicates the function of the damaged section of the hippocampus. This prosthetic device is built by a) creating an input-output model of the transformation between the ...
Source
#1Jordan W. Cline (UofU: University of Utah)
#2Clayton S. Bingham (SC: University of Southern California)H-Index: 2
Last.Gianluca Lazzi (UofU: University of Utah)H-Index: 28
view all 8 authors...
In order to decode the relationship between the activity of neuronal networks in the brain and the physiological response, multiple recording methods are available to monitor the spatial-temporal response of the neurons. Compared to single neuron recording that is useful for finding neuronal response, local field potential (LFP) recording allows for analysis of a larger neuronal network response. LFP is a combinational effect of the asynchronous action potentials from multiple neurons and can be...
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#1Clayton S. BinghamH-Index: 2
#2Kyle LoizosH-Index: 2
Last.Theodore W. BergerH-Index: 50
view all 8 authors...
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