John H. Stone
Harvard University
PathologyImmunologyVasculitisDiabetes mellitusMedicine
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Publications 541
PURPOSE OF REVIEW: Giant cell arteritis (GCA) has classically been diagnosed by temporal artery biopsy and treated with high-dose, long-term glucocorticoid therapy. Noninvasive imaging increasingly is employed for diagnostic purposes, but further studies are needed to determine the role of imaging in monitoring longitudinal disease activity. Glucocorticoid-sparing therapy mitigates the numerous adverse effects of glucocorticoids. This review addresses new developments in these areas. RECENT FIND...
1 CitationsSource
#1Lucia Sobrin (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 29
#2John H. Stone (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 70
Last. Rosalynn M. Nazarian (MEE: Massachusetts Eye and Ear Infirmary)
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A Man with Joint Pain and Eye Redness A 37-year-old man presented with arthralgias, rash, calf pain, and redness in both eyes. The C-reactive protein level was elevated, and the erythrocyte sedimen...
#1Zachary S. Wallace (Harvard University)H-Index: 18
#2Tyler Harkness (Harvard University)H-Index: 1
Last. Rochelle P. Walensky (Harvard University)H-Index: 53
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OBJECTIVE: Originator intravenous rituximab is an important rheumatology treatment but is costly, and administration requires several hours. Because biosimilar rituximab may cost less and subcutaneous rituximab requires a shorter visit, both may reduce costs and increase treatment capacity (infusions per year). METHODS: We implemented time-driven activity-based costing (TDABC), a method to assess costs and opportunities to increase capacity, throughout the care pathway for 26 patients receiving ...
#1Greg McDermott (Harvard University)
#2Xiaoqing Fu (Harvard University)
Last. Zachary S. WallaceH-Index: 18
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Importance Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic small vessel vasculitis characterized by circulating ANCAs targeting proteinase 3 (PR3) or myeloperoxidase (MPO) and associated with excess morbidity and mortality. Myeloperoxidase-ANCA–positive AAV and PR3-ANCA–positive AAV are increasingly recognized to have differences in genetic risk, pathogenesis, and response to treatment. Risk factors for AAV, including cigarette smoking, are poorly understood....
#1Mark Matza (Harvard University)
#2Ana D. Fernandes (Harvard University)
Last. Sebastian Unizony (Harvard University)H-Index: 14
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OBJECTIVE: To evaluate the efficacy and safety of ustekinumab (UST) in giant cell arteritis (GCA). METHODS: We conducted a prospective, open-label trial of UST in patients with active new-onset or relapsing GCA. Active disease was defined as the presence of GCA symptoms and erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) elevation within 6 weeks of baseline. All patients received a 24-week prednisone taper and subcutaneous UST 90mg at baseline, weeks 4, 12, 20, 28, 36 and 44. Th...
#1Zachary S. WallaceH-Index: 18
#2Hyon K. ChoiH-Index: 85
Last. John H. Stone (Harvard University)H-Index: 70
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We read with interest the article ‘Trimethoprim–sulfamethoxazole prophylaxis prevents severe/life-threatening infections following rituximab in antineutrophil cytoplasm antibody-associated vasculitis’ by Kronbichler et al .1 Severe infections continue to be a significant cause of morbidity and mortality in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), and we commend the authors for pursuing this study. However, we have several concerns regarding their methodolog...
2 CitationsSource
#1John H. Stone (Harvard University)H-Index: 70
#1Tyler Harkness (Harvard University)H-Index: 1
#2Xiaoqing Fu (Harvard University)
Last. Zachary S. Wallace (Harvard University)H-Index: 18
view all 7 authors...
BACKGROUND: Serum immunoglobulin G (IgG) concentrations are integral to the workup of immune deficiencies and IgG4-related disease (IgG4-RD). Demographic differences in IgG concentrations are poorly described but could influence test interpretation, contribute to racial disparities in primary immunodeficiency diagnosis, and explain demographic differences in IgG concentrations in IgG4-RD. OBJECTIVE: To assess differences in IgG and IgG subclass concentrations according to sex and race. METHODS: ...
1 CitationsSource
#1Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 14
#2Elena Rigamonti (UniSR: Vita-Salute San Raffaele University)H-Index: 8
Last. Shiv Pillai (Ragon Institute of MGH, MIT and Harvard)H-Index: 55
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Background IgG4-related disease (IgG4-RD) is a fibroinflammatory condition marked by rapid clinical improvement after selective depletion of B lymphocytes with rituximab. This feature suggests that B cells might participate in fibrogenesis and wound healing. Objective In the present work we aimed to demonstrate that B lymphocytes contribute directly to tissue fibrosis in patients with IgG4-RD. Methods Total circulating CD19+ B lymphocytes, naive B cells, memory B cells, or plasmablasts from pati...
#1Hang Liu (Ragon Institute of MGH, MIT and Harvard)
#1Hang Liu (PRC: China Medical University (PRC))H-Index: 1
Last. Shiv Pillai (Ragon Institute of MGH, MIT and Harvard)H-Index: 55
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OBJECTIVE: Four autoantigens have been described recently in IgG4-related disease (IgG4-RD): prohibitin, annexin A11, laminin 511-E8, and galectin-3. However, no external validation has been performed, and the possibility that some individuals break tolerance to more than 1 autoantigen has not been explored. We undertook this study to evaluate the relative frequencies of antibody responses against these autoantigens in order to explore the role of adaptive immune response in IgG4-RD. METHODS: Au...