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Christopher E. Ramsden
National Institutes of Health
52Publications
16H-index
1,614Citations
Publications 52
Newest
#1Christopher E. Ramsden (University of Adelaide)H-Index: 16
#2Zhi-Xin Yuan (NIH: National Institutes of Health)H-Index: 4
Last.Robert A. Gibson (University of Adelaide)H-Index: 58
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Abstract BACKGROUND Oxidized derivatives of polyunsaturated fatty acids, collectively known as oxylipins, are labile bioactive mediators with diverse roles in human physiology and pathology. Oxylipins are increasingly being measured in plasma collected in clinical studies to investigate biological mechanisms and as pharmacodynamic biomarkers for nutrient-based and drug-based interventions. Whole blood is generally stored either on ice or at room temperature prior to processing. However, the pote...
#1Anthony F. Domenichiello (NIH: National Institutes of Health)H-Index: 12
#2Anthony F. Domenichiello (NIH: National Institutes of Health)
Last.Christopher E. Ramsden (NIH: National Institutes of Health)H-Index: 16
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Abstract Chronic pain is highly prevalent among older adults where it is associated with significant suffering, disability, social isolation, and greater costs and burden to health care systems. Pharmaceutical treatment of chronic pain in older adults is usually only partially effective and is often limited by side effects including urinary retention, constipation, sedation, cognitive impairment, and increased risk of falls. Since older adults are underrepresented in clinical trials testing trea...
#1Richard D. SembaH-Index: 65
#2Ruin MoaddelH-Index: 30
Last.Luigi FerruciH-Index: 142
view all 5 authors...
Abstract Sarcopenia, the progressive loss of muscle mass, strength, and physical performance that occurs during aging, is highly prevalent among the elderly. Sarcopenia increases the risk of falls, disability, and death. The biological basis for sarcopenia is not well understood. There are no specific preventive or therapeutic strategies for sarcopenia except exercise. The elucidation of biological pathways and identification of therapeutic targets for treating or preventing sarcopenia remain a ...
#1Christopher E. Ramsden (University of Adelaide)H-Index: 16
#2Marie Hennebelle (UC Davis: University of California, Davis)H-Index: 5
Last.Daisy Zamora (NIH: National Institutes of Health)
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Abstract Background Linoleic acid (LA) is abundant in modern industrialized diets. Oxidized LA metabolites (OXLAMs) and reactive aldehydes, such as 4-hydroxy-2-nonenal (4-HNE), are present in heated vegetable oils and can be endogenously synthesized following consumption of dietary LA. OXLAMs have been implicated in cerebellar degeneration in chicks; 4-HNE is linked to neurodegenerative conditions in mammals. It unknown whether increasing dietary LA or OXLAMs alters the levels of oxidized fatty ...
#1Susanne Schuster (UCSD: University of California, San Diego)H-Index: 12
#2Casey D. Johnson (UCSD: University of California, San Diego)H-Index: 9
Last.Craig J. McClainH-Index: 63
view all 11 authors...
Author(s): Schuster, S; Johnson, CD; Hennebelle, M; Holtmann, T; Taha, AY; Kirpich, IA; Eguchi, A; Ramsden, CE; Papouchado, BG; McClain, CJ; Feldstein, AE | Abstract: © 2018 American Society for Biochemistry and Molecular Biology Inc. All Rights Reserved. Circulating oxidized linoleic acid (LA) metabolites (OXLAMs) are increased in patients with nonalcoholic steatohepatitis (NASH) and their levels correlate with disease severity. However, the mechanisms by which OXLAMs contribute to NASH develop...
#1J.R. Jensen (NIH: National Institutes of Health)H-Index: 1
#2Mark H. PitcherH-Index: 5
Last.Anthony F. Domenichiello (NIH: National Institutes of Health)H-Index: 12
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Abstract Chronic pain is both a global public health concern and a serious source of personal suffering for which current treatments have limited efficacy. Recently, oxylipins derived from linoleic acid (LA), the most abundantly consumed polyunsaturated fatty acid in the modern diet, have been implicated as mediators of pain in the periphery and spinal cord. However, oxidized linoleic acid derived mediators (OXLAMs) remain understudied in the brain, particularly during pain states. In this study...
#1Yuhong Lin (NIH: National Institutes of Health)H-Index: 5
#2Joseph R. Hibbeln (NIH: National Institutes of Health)H-Index: 46
Last.Stanley I. Rapoport (NIH: National Institutes of Health)H-Index: 94
view all 12 authors...
#1Danielle M. LaPaglia (NIH: National Institutes of Health)H-Index: 2
#2Matthew R. Sapio (NIH: National Institutes of Health)H-Index: 4
Last.Andrew J. Mannes (NIH: National Institutes of Health)H-Index: 2
view all 9 authors...
BackgroundThe trigeminal ganglion contains neurons that relay sensations of pain, touch, pressure, and many other somatosensory modalities to the central nervous system. The ganglion is also a reservoir for latent herpes virus 1 infection. To gain a better understanding of molecular factors contributing to migraine and headache, transcriptome analyses were performed on postmortem human trigeminal ganglia.MethodsRNA-Seq measurements of gene expression were conducted on small sub-regions of 16 hum...
#1Alexander V. Sorokin (NIH: National Institutes of Health)H-Index: 11
#2Anthony F. Domenichiello (NIH: National Institutes of Health)H-Index: 12
Last.Nehal N. Mehta (NIH: National Institutes of Health)H-Index: 37
view all 9 authors...
Psoriasis is a chronic immune-mediated disease that represents a unique model for investigating inflammation at local and systemic levels. Bioactive lipid mediators (LMs) are potent compounds reported to play a role in the development and resolution of inflammation. Currently, it is not known to what extent these LMs are involved in psoriasis pathophysiology and related metabolic dysfunction. Here, we use targeted and untargeted liquid chromatography-tandem mass spectrometry approaches to quanti...
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