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Christopher E. Ramsden
National Institutes of Health
50Publications
16H-index
1,610Citations
Publications 50
Newest
Anthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health),
Christopher E. Ramsden16
Estimated H-index: 16
(National Institutes of Health)
Abstract Chronic pain is highly prevalent among older adults where it is associated with significant suffering, disability, social isolation, and greater costs and burden to health care systems. Pharmaceutical treatment of chronic pain in older adults is usually only partially effective and is often limited by side effects including urinary retention, constipation, sedation, cognitive impairment, and increased risk of falls. Since older adults are underrepresented in clinical trials testing trea...
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Published on Oct 1, 2018in Biochimica et Biophysica Acta 3.44
Christopher E. Ramsden16
Estimated H-index: 16
(University of Adelaide),
Marie Hennebelle5
Estimated H-index: 5
(University of California, Davis)
+ 12 AuthorsAriel E. Feldstein55
Estimated H-index: 55
(University of California, San Diego)
Abstract Background Linoleic acid (LA) is abundant in modern industrialized diets. Oxidized LA metabolites (OXLAMs) and reactive aldehydes, such as 4-hydroxy-2-nonenal (4-HNE), are present in heated vegetable oils and can be endogenously synthesized following consumption of dietary LA. OXLAMs have been implicated in cerebellar degeneration in chicks; 4-HNE is linked to neurodegenerative conditions in mammals. It unknown whether increasing dietary LA or OXLAMs alters the levels of oxidized fatty ...
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Published on Sep 1, 2018in Analytical and Bioanalytical Chemistry 3.31
Zhi-Xin Yuan4
Estimated H-index: 4
(National Institutes of Health),
Sharon Majchrzak-Hong8
Estimated H-index: 8
(National Institutes of Health)
+ 3 AuthorsChristopher E. Ramsden16
Estimated H-index: 16
Oxylipins are bioactive mediators that play diverse roles in (patho)physiology. We developed a sensitive and selective ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous profiling of 57 targeted oxylipins derived from five major n-6 and n-3 polyunsaturated fatty acids (PUFAs) that serve as oxylipin precursors, including linoleic (LA), arachidonic (AA), alpha-linolenic (ALA), eicosapentaenoic (EPA), and docosahexaenoic (DHA) acids. The target...
4 Citations Source Cite
Published on Sep 1, 2018in Journal of Lipid Research 4.50
Susanne Schuster12
Estimated H-index: 12
(University of California, San Diego),
Casey D. Johnson9
Estimated H-index: 9
(University of California, San Diego)
+ 8 AuthorsCraig J. McClain63
Estimated H-index: 63
Author(s): Schuster, S; Johnson, CD; Hennebelle, M; Holtmann, T; Taha, AY; Kirpich, IA; Eguchi, A; Ramsden, CE; Papouchado, BG; McClain, CJ; Feldstein, AE | Abstract: © 2018 American Society for Biochemistry and Molecular Biology Inc. All Rights Reserved. Circulating oxidized linoleic acid (LA) metabolites (OXLAMs) are increased in patients with nonalcoholic steatohepatitis (NASH) and their levels correlate with disease severity. However, the mechanisms by which OXLAMs contribute to NASH develop...
1 Citations Source Cite
J.R. Jensen1
Estimated H-index: 1
(National Institutes of Health),
Mark H. Pitcher5
Estimated H-index: 5
+ 2 AuthorsAnthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health)
Abstract Chronic pain is both a global public health concern and a serious source of personal suffering for which current treatments have limited efficacy. Recently, oxylipins derived from linoleic acid (LA), the most abundantly consumed polyunsaturated fatty acid in the modern diet, have been implicated as mediators of pain in the periphery and spinal cord. However, oxidized linoleic acid derived mediators (OXLAMs) remain understudied in the brain, particularly during pain states. In this study...
1 Citations Source Cite
Published on May 1, 2018in Lipids 1.94
Yuhong Lin5
Estimated H-index: 5
(National Institutes of Health),
Joseph R. Hibbeln46
Estimated H-index: 46
(National Institutes of Health)
+ 9 AuthorsStanley I. Rapoport94
Estimated H-index: 94
(National Institutes of Health)
2 Citations Source Cite
Published on Apr 1, 2018in Cephalalgia 3.89
Danielle M. LaPaglia2
Estimated H-index: 2
(National Institutes of Health),
Matthew R. Sapio4
Estimated H-index: 4
(National Institutes of Health)
+ 6 AuthorsAndrew J. Mannes2
Estimated H-index: 2
(National Institutes of Health)
BackgroundThe trigeminal ganglion contains neurons that relay sensations of pain, touch, pressure, and many other somatosensory modalities to the central nervous system. The ganglion is also a reservoir for latent herpes virus 1 infection. To gain a better understanding of molecular factors contributing to migraine and headache, transcriptome analyses were performed on postmortem human trigeminal ganglia.MethodsRNA-Seq measurements of gene expression were conducted on small sub-regions of 16 hum...
11 Citations Source Cite
Published on Feb 1, 2018in Journal of Investigative Dermatology 6.45
Alexander V. Sorokin11
Estimated H-index: 11
(National Institutes of Health),
Anthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health)
+ 6 AuthorsNehal N. Mehta37
Estimated H-index: 37
(National Institutes of Health)
Psoriasis is a chronic immune-mediated disease that represents a unique model for investigating inflammation at local and systemic levels. Bioactive lipid mediators (LMs) are potent compounds reported to play a role in the development and resolution of inflammation. Currently, it is not known to what extent these LMs are involved in psoriasis pathophysiology and related metabolic dysfunction. Here, we use targeted and untargeted liquid chromatography-tandem mass spectrometry approaches to quanti...
4 Citations Source Cite
John Douglas Mann4
Estimated H-index: 4
,
Keturah R. Faurot15
Estimated H-index: 15
(University of North Carolina at Chapel Hill)
+ 9 AuthorsDavid A. Barrow14
Estimated H-index: 14
Abstract Migraine is a prevalent neurological disorder, affecting over 16% of adult women and 7% of adult men in the U.S., causing significant pain, disability, and medical expense, with incomplete benefits from conventional medical management. Migraine, as a chronic pain syndrome, provides a practical model for investigating the impact of dietary modifications in omega-3 (n-3) and omega-6 (n-6) fatty acids. This paper reports the protocol of a trial to assess whether targeted dietary modificati...
2 Citations Source Cite
Anthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health),
Breanne C. Wilhite1
Estimated H-index: 1
(National Institutes of Health)
+ 1 AuthorsChristopher E. Ramsden16
Estimated H-index: 16
(National Institutes of Health)
Abstract Inhibition of prostaglandin (PG) biosynthesis has been used to relieve pain for thousands of years. Today non-steroidal anti-inflammatory drugs (which largely inhibit PG synthesis) are widely used to treat pain. Four main types of PGs (PGD2, PGE2, PGF2 and PGI2) are synthesized from arachidonic acid during inflammation and have been demonstrated to impact nociception. PGE2 has been the most studied and utilized for its pain producing properties and has been demonstrated to increase hype...
1 Citations Source Cite
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