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J.W. Von den Hoff
Radboud University Nijmegen Medical Centre
45Publications
19H-index
1,045Citations
Publications 46
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#1D.H. Rosero Salazar (Radboud University Nijmegen)
#2P.L. Carvajal Monroy (Radboud University Nijmegen)
Last.J.W. Von den Hoff (Radboud University Nijmegen)H-Index: 19
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Orofacial congenital defects such as cleft lip and/or palate are associated with impaired muscle regeneration and fibrosis after surgery. Also, other orofacial reconstructions or trauma may end up ...
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#1I. G. E. Gebuijs (Radboud University Nijmegen)
#2S. T. Raterman (Radboud University Nijmegen)
Last.J.W. Von den HoffH-Index: 19
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ABSTRACT Craniofacial development is tightly regulated and therefore highly vulnerable to disturbance by genetic and environmental factors. Fibroblast growth factors (FGFs) direct migration, proliferation and survival of cranial neural crest cells (CNCCs) forming the human face. In this study, we analyzed bone and cartilage formation in the head of five dpf fgf8ati282 zebrafish larvae and assessed gene expression levels for 11 genes involved in these processes. In addition, in situ hybridization...
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#1C.D. Schoen (Radboud University Nijmegen)H-Index: 1
#2Jeffrey C. Glennon (Radboud University Nijmegen)H-Index: 14
Last.J.W. Von den Hoff (Radboud University Nijmegen)H-Index: 19
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6 CitationsSource
#1J Zhu (WHU: Wuhan University)H-Index: 1
#2Xinhuan Wang (WHU: Wuhan University)H-Index: 3
Last.Liuyan Meng (WHU: Wuhan University)H-Index: 8
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Dens invaginatus is a malformation with varying anatomical features, posing challenges to treatment. Early and accurate diagnosis plays a significant role in selecting the appropriate treatment. The diagnosis of teeth with a complex root canal system including dens invaginatus has made progress with the application of three-dimensional imaging techniques in endodontics. Advanced treatment options provide hope for teeth that could not be saved before. This review discusses diagnostic methods and ...
3 CitationsSource
Although palatal muscle reconstruction in patients with cleft palate takes place during early childhood, normal speech development is often not achieved. We hypothesized that the intrinsic properties of head satellite cells (SCs) and the young age of these patients contribute to the poor muscle regeneration after surgery. First, we studied the fiber type distribution and the expression of SC markers in ex vivo muscle tissue from head (branchiomeric) and limb (somite-derived) muscles from neonata...
4 CitationsSource
#1J.W. Von den HoffH-Index: 19
Last.P.L. Carvajal MonroyH-Index: 2
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Last.Carine CarelsH-Index: 29
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1 Citations
#1P.L. Carvajal Monroy (Radboud University Nijmegen)H-Index: 2
#2Sander Grefte (WUR: Wageningen University and Research Centre)H-Index: 13
Last.J.W. Von den Hoff (Radboud University Nijmegen)H-Index: 19
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Muscle repair is a crucial component of palatoplasty but little is known about muscle regeneration after cleft palate repair. We hypothesized that the formation of new myofibers is hampered by collagen accumulation after experimental injury of the soft palate of rats. One-millimeter excisional defects were made in the soft palates of 32 rats. The wound area was evaluated after 3, 7, 28, and 56 days using azocarmine G and aniline blue to stain for collagen and immunohistochemistry to identify myo...
5 CitationsSource
#1Katrien M. Brouwer (Radboud University Nijmegen)H-Index: 9
#2Ditte M. S. Lundvig (Radboud University Nijmegen)H-Index: 7
Last.J.W. Von den Hoff (Radboud University Nijmegen)H-Index: 19
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Cleft lip and palate patients suffer from functional, aesthetical, and psychosocial problems due to suboptimal regeneration of skin, mucosa, and skeletal muscle after restorative cleft surgery. The field of tissue engineering and regenerative medicine (TE/RM) aims to restore the normal physiology of tissues and organs in conditions such as birth defects or after injury. A crucial factor in cell differentiation, tissue formation, and tissue function is mechanical strain. Regardless of this, mecha...
9 CitationsSource
#1Mette A. R. Kuijpers (University of Geneva)H-Index: 9
#2Sander Grefte (Radboud University Nijmegen Medical Centre)H-Index: 13
Last.J.W. Von den Hoff (Radboud University Nijmegen Medical Centre)H-Index: 19
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summary The physiology of masseter muscles is known to change in response to functional demands, but the effect on the satellite cell (SC) population is not known. In this study, the hypothesis is tested that a decreased functional demand of the masseter muscle causes a reduction of SCs. To this end, twelve 5-week-old male Sprague–Dawley rats were put on a soft diet (SD, n = 6) or a hard diet (HD, n = 6) and sacrificed after 14 days. Paraffin sections of the superficial masseter and the m. digas...
1 CitationsSource
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