Giancarlo Marra
University of Zurich
Publications 158
#1Riccardo Schiavina (UNIBO: University of Bologna)H-Index: 30
#2Andrea Mari (UniFI: University of Florence)H-Index: 13
Last.Fabrizio Di Maida (UniFI: University of Florence)H-Index: 2
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Abstract Purpose to evaluate clinical predictors of positive surgical margins (PSMs) in a large multicenter prospective observational study and to develop a clinic nomogram to predict the likelihood of PSMs after partial nephrectomy (PN). Materials and methods We prospectively evaluated 4308 patients who had surgical treatment for renal tumors between January 2013 and December 2016 at 26 urological Italian Centers (RECORd 2 project). Two multivariable logistic models were evaluated to predict th...
#1Faiza Noreen (University of Basel)H-Index: 4
#2Taya Küng (University of Basel)
Last.Primo Schär (University of Basel)H-Index: 35
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Background Aberrations in DNA methylation are widespread in colon cancer (CC). Understanding origin and progression of DNA methylation aberrations is essential to develop effective preventive and therapeutic strategies. Here, we aimed to dissect CC subtype-specific methylation instability to understand underlying mechanisms and functions.
#1Stephany Orjuela (UZH: University of Zurich)H-Index: 1
#2Dania Machlab (FMI: Friedrich Miescher Institute for Biomedical Research)H-Index: 1
Last.Mark D. Robinson (UZH: University of Zurich)H-Index: 47
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DNA methylation is a highly studied epigenetic signature that is associated with regulation of gene expression, whereby genes with high levels of promoter methylation are generally repressed. Genomic imprinting occurs when one of the parental alleles is methylated, i.e, when there is inherited allele-specific methylation (ASM). A special case of imprinting occurs during X chromosome inactivation in females, where one of the two X chromosomes is silenced, in order to achieve dosage compensation b...
1 CitationsSource
#2Ilaria GregnaninH-Index: 2
Last.Giovanna ChiorinoH-Index: 31
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The dosage of prostate-specific antigen (PSA), an easily evaluable and non-invasive biomarker, has made early detection of prostate cancer (PCa) possible. However, it leads to high percentages of unnecessary biopsies and may miss aggressive tumors in men with PSA levels below 4 ng/ml. Therefore, we propose to combine circulating microRNAs (miRs) with PSA, to improve the diagnostic route for PCa. Plasma miR profiling identified candidate diagnostic miRs in a discovery cohort of 60 tumors and 60 c...
4 CitationsSource
#1Marco OderdaH-Index: 13
#2Giancarlo MarraH-Index: 44
Last.Paolo GonteroH-Index: 32
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INTRODUCTION AND OBJECTIVES:In a large multicenter series, we assessed the impact of performing a standard systematic sampling of the prostate in addition to mpMRI-targeted biopsies, in terms of prostate cancer (PCa) and clinically significant (cs) PCa detection.METHODS:We retrospectively enrolled 1.119 patients out of a multicenter retrospective database of 2.115 mpMRI-targeted biopsies. Biopsies were performed using the KoelisTM platform between 2010 and 2017 and consisted in targeted (median ...
#1Paolo GonteroH-Index: 32
#2Giancarlo MarraH-Index: 44
Last.R.J. Karnes (UR: University of Rochester)H-Index: 1
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