Nicolas A. Menzies
Harvard University
ImmunologyTuberculosisPopulationMedicineEnvironmental health
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Publications 55
BACKGROUND: Baltimore and San Francisco represent high burden areas for gonorrhea in the United States. We explored different gonorrhea screening strategies and their comparative impact in the 2 cities. METHODS: We used a compartmental transmission model of gonorrhea stratified by sex, sexual orientation, age, and race/ethnicity, calibrated to city-level surveillance data for 2010 to 2017. We analyzed the benefits of 5-year interventions which improved retention in care cascade or increased scre...
#1Matthew Quaife (Lond: University of London)H-Index: 6
#2Rein M. G. J. Houben (Lond: University of London)H-Index: 21
Last. Robert S. WallisH-Index: 52
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#1Nicolas A. Menzies (Harvard University)H-Index: 11
#2Andrea Parriott (UCSF: University of California, San Francisco)H-Index: 3
Last. Priya B. Shete (UCSF: University of California, San Francisco)H-Index: 8
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Rationale Mathematical modelling is used to understand disease dynamics, forecast trends, and inform public health prioritization. We conducted a comparative analysis of tuberculosis (TB) epidemiol...
1 CitationsSource
#1Nicolas A. MenziesH-Index: 11
#2Christian SuharlimH-Index: 4
Last. Logan BrenzelH-Index: 7
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Abstract Background Few studies have systematically examined the efficiency of routine infant immunization services. Using a representative sample of infant immunization sites in Benin, Ghana, Honduras, Moldova, Uganda and Zambia (316 total), we estimated average efficiency levels and variation in efficiency within each country, and investigated the properties of published efficiency estimation techniques. Methods Using a dataset describing 316 immunization sites we estimated site-level efficien...
#1Cristina Munk (Harvard University)
#2Allison Portnoy (Harvard University)H-Index: 6
Last. Nicolas A. Menzies (Harvard University)H-Index: 11
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Background In recent years, several large studies have assessed the costs of national infant immunization programs, and the results of these studies are used to support planning and budgeting in low- and middle-income countries. However, few studies have addressed the costs and cost-effectiveness of interventions to improve immunization coverage, despite this being a major focus of policy attention. Without this information, countries and international stakeholders have little objective evidence...
Objectives: Value of information (VOI) analyses can help policy-makers make informed decisions about whether to conduct and how to design future studies. Historically, a computationally expensive method to compute the Expected Value of Sample Information (EVSI) restricted the use of VOI to simple decision models and study designs. Recently, four EVSI approximation methods have made such analyses more feasible and accessible. We provide practical recommendations for analysts computing EVSI by eva...
#1Minttu M Rönn (Harvard University)H-Index: 6
#2Nicolas A. Menzies (Harvard University)H-Index: 11
Last. Joshua A. Salomon (Stanford University)H-Index: 84
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#1Emma Clarke-Deelder (Harvard University)
#2Anna Vassall (Lond: University of London)H-Index: 2
Last. Nicolas A. Menzies (Harvard University)H-Index: 11
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Abstract Background In low- and middle-income countries, multisite costing studies are increasingly used to estimate healthcare program costs. These studies have employed a variety of estimators to summarize sample data and make inferences about overall program costs. Objective We conducted a systematic review and simulation study to describe these estimation methods and quantify their performance in terms of expected bias and variance. Methods We reviewed the published literature through Januar...
#1James M. Trauer (Monash University)H-Index: 11
#2Peter J. Dodd (University of Sheffield)H-Index: 15
Last. David Wesley Dowdy (Johns Hopkins University)H-Index: 38
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Although less well-recognised than for other infectious diseases, heterogeneity is a defining feature of TB epidemiology. To advance toward TB elimination, this heterogeneity must be better understood and addressed. Drivers of heterogeneity in TB epidemiology act at the level of the infectious host, organism, susceptible host, environment and distal determinants. These effects may be amplified by social mixing patterns, while the variable latent period between infection and disease may mask hete...
4 CitationsSource
#1Sarah F. McGough (Harvard University)H-Index: 2
#2Michael A. Johansson (CDC: Centers for Disease Control and Prevention)H-Index: 25
Last. Nicolas A. Menzies (Harvard University)H-Index: 11
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Abstract Delays in case reporting are common to disease surveillance systems, making it difficult to track diseases in real-time. “Nowcast” approaches attempt to estimate the complete case counts for a given reporting date, using a time series of case reports that is known to be incomplete due to reporting delays. Modeling the reporting delay distribution is a common feature of nowcast approaches. However, many nowcast approaches ignore a crucial feature of infectious disease transmission—that f...