Bernhard Hellmich
University of Tübingen
PathologyPhysical therapyImmunologyVasculitisMedicine
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Publications 137
#1E. Csernok (University of Tübingen)H-Index: 1
#2Bernhard Hellmich (University of Tübingen)H-Index: 35
The cornerstone of the laboratory diagnostics of small vessel vasculitis is the detection of antineutrophil cytoplasmic antibodies (ANCA). The current international consensus recommendations suggest that proteinase 3 (PR3) and myeloperoxidase (MPO) ANCA immunoassays should be used as a first-line test if there is a justified suspicion of ANCA-associated vasculitis (AAV). A second method is only recommendable when the immunoassay shows a negative or borderline result. The precise identification o...
: Despite advances in the diagnosis and treatment, the mortality rate of Takayasu arteritis (TAK) is still elevated even today. The diagnosis is often made after a long time delay and the course of the disease is characterized by progressive structural vascular lesions. Recently, new recommendations for the management of large vessel vasculitis were published by the European League Against Rheumatism (EULAR). For induction of remission oral glucocorticoids (GC) are administered in an initial dai...
#1Elena Csernok (University of Tübingen)H-Index: 2
#1Elena Csernok (University of Tübingen)H-Index: 50
Last. Bernhard Hellmich (University of Tübingen)H-Index: 35
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Abstract In recent years, insight into immune pathogenesis and treatment of primary systemic vasculitides (PSV) has increased considerably, and has led to the development of many clinically relevant biomarkers. This review aims to provide an update on the main biomarkers discovered and their potential application to precision medicine in vasculitis. Genetic and molecular profiling of patients and promising biomarkers discoveries are very important for personalized medicine; however, there are ve...
#1Lena Horvath (University of Tübingen)
#2Bernhard Hellmich (University of Tübingen)H-Index: 35
Patienten mit unbehandelter aktiver Riesenzellarteriitis sind durch das Risiko eines permanenten Visusverlusts akut gefahrdet, sodass umgehend eine Therapie mit Glukokortikoiden in einer Initialdosis von 40–60 mg Prednisolonaquivalent pro Tag begonnen werden sollte. Sobald eine Remission eingetreten ist, sollte die Prednisolon-Dosis innerhalb von 2 bis 3 Monaten auf 15–20 mg und danach innerhalb 1 Jahres auf ≤5 mg pro Tag reduziert werden. Bei Patienten mit erhohtem Risiko fur oder bereits beste...
Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are the most frequent primary necrotizing small vessel vasculitides. In these formerly fatal diseases remission can be induced by stage- and activity-adapted immunosuppressive regimens in the majority of patients. This does not lead to drug-free long-term remission or even cure. Consequently, maintenance of remission medication is needed. Recent randomized controlled trials demonstrated that maintenance treatment with the ...
#1Bernhard Hellmich (University of Tübingen)H-Index: 35
#2Ana Filipa ÁguedaH-Index: 3
Last. Raashid Luqmani (University of Oxford)H-Index: 53
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Background Since the publication of the European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis (LVV) in 2009, several relevant randomised clinical trials and cohort analyses have been published, which have the potential to change clinical care and therefore supporting the need to update the original recommendations. Methods Using EULAR standardised operating procedures for EULAR-endorsed recommendations, the EULAR task force undertook a systemati...
7 CitationsSource
#1Matthias PapoH-Index: 4
Last. B. TerrierH-Index: 3
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Introduction La granulomatose eosinophilique avec polyangeite (GEPA) (Churg-Strauss) est une vascularite necrosante des vaisseaux de petit calibre caracterisee par une eosinophilie sanguine et tissulaire associee a un asthme. Les ANCA sont positifs dans seulement un tiers des cas, le plus souvent diriges contre la myeloperoxydase (MPO). Les patients ANCA+ ont plus de manifestations neurologiques et renales, et moins de manifestations cardiaques que les patients ANCA−. Les ANCA diriges contre la ...
#1Bernhard Hellmich (University of Tübingen)H-Index: 35
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Severe, organ-threatening and life-threatening manifestations of inflammatory rheumatic diseases, such as diffuse alveolar hemorrhage in the context of small vessel vasculitis, sometimes inadequately respond to immunosuppressive treatment. In the case of an immanent or already occurring organ failure, immunosuppressive treatment may need to be supplemented with rapidly effective rescue treatment procedures. Due to the rarity of many rheumatic diseases, the evidence for the use of rescue treatmen...
#1E. EdelmannH-Index: 3
#2H.-J. Lakomek (RUB: Ruhr University Bochum)H-Index: 1
Last. S. ZinkeH-Index: 3
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Mit der ambulanten spezialfacharztlichen Versorgung (ASV) nach § 116b SGB (Sozialgesetzbuch) V besteht seit April 2018 eine dritte Versorgungsebene, in der Patienten mit chronisch entzundlichen Rheumaerkrankungen behandelt werden konnen. Die Kooperation von verschiedenen Facharztgruppen, die an der Rheumaversorgung beteiligt sind, wird gefordert, auch die sektorenubergreifende Kooperation zwischen Rheumatologen wie auch anderen Facharzten in der Praxis und im Krankenhaus. Durch den Wegfall der B...
#1Christian Löffler (University of Tübingen)H-Index: 2
#2Bernhard Hellmich (University of Tübingen)H-Index: 35
Die Sonografie spielt in der rheumatologischen Diagnostik neben Anamnese, korperlicher Untersuchung und Labor eine zentrale Rolle. In der Klinik ermoglicht die rasche Verfugbarkeit der Sonografie eine zeitnahe Diagnostik bei unterschiedlichen Fragestellungen in der Rheumatologie und liefert durch die Moglichkeit dynamischer Untersuchungen zusatzliche Informationen, welche gegebenenfalls andere bildgebende Verfahren erganzen. Die Arthrosonografie grenzt nicht nur entzundliche von nicht entzundlic...