Margaret A. Taub
Johns Hopkins University
Publications 62
#1Michelle Daya (University of Colorado Denver)H-Index: 10
#2Nicholas Rafaels (University of Colorado Denver)H-Index: 26
Last.Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
view all 65 authors...
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find ...
3 CitationsSource
#1Meher Preethi Boorgula (University of Colorado Denver)H-Index: 9
#2Margaret A. Taub (Johns Hopkins University)H-Index: 18
Last.Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
view all 21 authors...
Although epigenetic mechanisms are important risk factors for allergic disease, few studies have evaluated DNA methylation differences associated with atopic dermatitis (AD), and none has focused on AD with eczema herpeticum (ADEH+). We will determine how methylation varies in AD individuals with/without EH and associated traits. We modeled differences in genome-wide DNA methylation in whole blood cells from 90 ADEH+, 83 ADEH−, and 84 non-atopic, healthy control subjects, replicating in 36 ADEH+...
#1Michelle Daya (University of Colorado Denver)H-Index: 10
#2Caapa (University of Colorado Denver)
Last.Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
view all 66 authors...
#1Alexander G. Bick (Harvard University)H-Index: 19
#2Joshua S. Weinstock (UM: University of Michigan)H-Index: 1
Last.Sekar Kathiresan (Broad Institute)H-Index: 106
view all 123 authors...
Age is the dominant risk factor for most chronic human diseases; yet the mechanisms by which aging confers this risk are largely unknown. Recently, the age-related acquisition of somatic mutations in regenerating hematopoietic stem cell populations was associated with both hematologic cancer incidence and coronary heart disease prevalence. Somatic mutations with leukemogenic potential may confer selective cellular advantages leading to clonal expansion, a phenomenon termed 9Clonal Hematopoiesis ...
1 CitationsSource
#1Margaret A. Taub (Johns Hopkins University)H-Index: 18
#2Joshua S. Weinstock (UM: University of Michigan)H-Index: 1
Last.Rasika A. Mathias (Johns Hopkins University)H-Index: 44
view all 125 authors...
Telomeres shorten in replicating somatic cells and with age; in human leukocytes, telomere length (TL) is associated with a host of aging-related diseases. To date, 16 genome-wide association studies (GWAS) have identified twenty-three loci associated with leukocyte TL, but prior studies were primarily in individuals of European and Asian ancestry and relied on laboratory assays including Southern Blot and qPCR to quantify TL. Here, we estimated TL bioinformatically, leveraging whole genome sequ...
#1Nandita Mukhopadhyay (University of Pittsburgh)H-Index: 7
#2Madison Bishop (Emory University)
Last.Mary L. Marazita (University of Pittsburgh)H-Index: 55
view all 19 authors...
Orofacial clefts (OFCs) are one of the most common birth defects worldwide and create a significant health burden. The majority of OFCs are non-syndromic, and the genetic component has been only partially determined. Here, we analyze whole genome sequence (WGS) data for association with risk of OFCs in European and Colombian families selected from a multicenter family-based OFC study. Part of the Gabriella Miller Kids First Pediatric Research Program, this is the first large-scale WGS study of O...
#1Jacob Fiksel (Johns Hopkins University)H-Index: 3
#2Leah Ruth Jager (Johns Hopkins University)H-Index: 6
Last.Margaret A. Taub (Johns Hopkins University)H-Index: 18
view all 4 authors...
AbstractGit and GitHub are common tools for keeping track of multiple versions of data analytic content, which allow for more than one person to simultaneously work on a project. GitHub Classroom a...
#1Ali R. Keramati (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 7
#2Lisa R. Yanek (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 44
Last.Rasika A. Mathias (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 44
view all 9 authors...
AbstractCoronary artery disease (CAD) remains a major cause of mortality and morbidity worldwide. The aggregation of activated platelets on a ruptured atherosclerotic plaque is a critical step in m...
3 CitationsSource
#1Candelaria Vergara (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 18
#2Chloe L. Thio (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 45
Last.Priya Duggal (Johns Hopkins University)H-Index: 32
view all 30 authors...
Background & Aims Spontaneous clearance of hepatitis C virus (HCV) occurs in approximately 30% of infected persons and less often in populations of African ancestry. Variants in major histocompatibility complex (MHC) and in interferon lambda genes are associated with spontaneous HCV clearance, but there have been few studies of these variants in persons of African ancestry. We performed a dense multi-ancestry genome-wide association study of spontaneous clearance of HCV, focusing on individuals ...
#1Rachel M. Sherman (Johns Hopkins University)H-Index: 2
#2Juliet Forman (HMC: Harvey Mudd College)H-Index: 1
Last.Steven L. SalzbergH-Index: 128
view all 46 authors...
In the version of this article initially published, the statement “there are no pan-genomes for any other animal or plant species” was incorrect. The statement has been corrected to “there are no reported pan-genomes for any other animal species, to our knowledge.” We thank David Edwards for bringing this error to our attention. The error has been corrected in the HTML and PDF versions of the article.
1 CitationsSource