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Jason L. Sanders
Harvard University
47Publications
18H-index
914Citations
Publications 47
Newest
Published on Jun 25, 2019in JAMA 51.27
Surya P. Bhatt19
Estimated H-index: 19
(UAB: University of Alabama at Birmingham),
Pallavi Balte4
Estimated H-index: 4
(CUMC: Columbia University Medical Center)
+ 12 AuthorsJason L. Sanders18
Estimated H-index: 18
(Brigham and Women's Hospital)
Importance According to numerous current guidelines, the diagnosis of chronic obstructive pulmonary disease (COPD) requires a ratio of the forced expiratory volume in the first second to the forced vital capacity (FEV 1 :FVC) of less than 0.70, yet this fixed threshold is based on expert opinion and remains controversial. Objective To determine the discriminative accuracy of various FEV 1 :FVC fixed thresholds for predicting COPD-related hospitalization and mortality. Design, Setting, and Partic...
Published on Apr 30, 2019in Metabolites
Megan M. Marron4
Estimated H-index: 4
,
Tamara B. Harris170
Estimated H-index: 170
+ 10 AuthorsRavi V. Shah36
Estimated H-index: 36
Black versus white older Americans are more likely to experience frailty, a condition associated with adverse health outcomes. To reduce racial disparities in health, a complete understanding of the pathophysiology of frailty is needed. Metabolomics may further our understanding by characterizing differences in the body during a vigorous versus frail state. We sought to identify metabolites and biological pathways associated with vigor to frailty among 287 black men ages 70–81 from the Health, A...
Matthew D.L. O’Connell8
Estimated H-index: 8
(Warw.: University of Warwick),
Megan M. Marron4
Estimated H-index: 4
(University of Pittsburgh)
+ 6 AuthorsA. B. Newman140
Estimated H-index: 140
(University of Pittsburgh)
Background Baseline scores on a Healthy Aging Index (HAI), including five key physiologic domains, strongly predict health outcomes. This study aimed to characterize 9-year changes in a HAI and explore their relationship to subsequent mortality. Methods Data are from the Health, Aging, and Body Composition study of well-functioning adults aged 70–79 years. A HAI, which ranges from 0 to 10, was constructed at years 1 and 10 of the study including systolic blood pressure, forced expiratory volume,...
Jason L. Sanders18
Estimated H-index: 18
(Harvard University),
Alice M. Arnold58
Estimated H-index: 58
(UW: University of Washington)
+ 8 AuthorsStephen B. Kritchevsky96
Estimated H-index: 96
(Wake Forest University)
Published on Jan 1, 2019in Experimental Gerontology 3.08
Carlos A. Vaz Fragoso18
Estimated H-index: 18
(Yale University),
Todd M. Manini44
Estimated H-index: 44
(UF: University of Florida)
+ 8 AuthorsSteve Cummings152
Estimated H-index: 152
(CPMC: California Pacific Medical Center)
Abstract Background We provide the first examination of mitochondrial DNA (mtDNA) variants and pulmonary function in older persons. Methods Cross-sectional associations between mtDNA variants and pulmonary function were evaluated as a combined p -values meta-analysis, using data from two independent cohorts of older persons. The latter included white and black participants, aged ≥70 years, from the Lifestyle Interventions and Independence for Elders study (LIFE) ( N = 1247) and the Health, Aging...
Published on Dec 1, 2018in Nature Communications 11.88
Annah B. Wyss5
Estimated H-index: 5
(NIH: National Institutes of Health),
Tamar Sofer15
Estimated H-index: 15
(Harvard University)
+ 99 AuthorsMary F. Feitosa46
Estimated H-index: 46
(WashU: Washington University in St. Louis)
Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in anc...
Jason L. Sanders18
Estimated H-index: 18
(Harvard University),
Wensheng Guo28
Estimated H-index: 28
(UPenn: University of Pennsylvania)
+ 6 AuthorsAnne R. Cappola40
Estimated H-index: 40
(UPenn: University of Pennsylvania)
Published on Oct 5, 2017in bioRxiv
Annah B. Wyss5
Estimated H-index: 5
(NIH: National Institutes of Health),
Tamar Sofer15
Estimated H-index: 15
(UW: University of Washington)
+ 88 AuthorsMary F. Feitosa46
Estimated H-index: 46
(WashU: Washington University in St. Louis)
Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N=60,552), African (N=8,429), Asian (N=9,959), and Hispanic/Latino (N=11,775) ethnicities. We identified over 50 novel loci at genome-wide significance in ancestry-spe...
Chenkai Wu5
Estimated H-index: 5
(OSU: Oregon State University),
Ellen Smit17
Estimated H-index: 17
(OSU: Oregon State University)
+ 2 AuthorsMichelle C. Odden25
Estimated H-index: 25
(OSU: Oregon State University)
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