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Fabiana Seguin
State University of Campinas
6Publications
4H-index
222Citations
Publications 6
Newest
Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model
8 CitationsSource
#1Michelle Agostini (State University of Campinas)H-Index: 11
#2Luciana Yamamoto Almeida (State University of Campinas)H-Index: 5
Last.Edgard Graner (State University of Campinas)H-Index: 36
view all 13 authors...
Fatty acid synthase (FASN) is the biosynthetic enzyme responsible for the endogenous synthesis of fatty acids. It is downregulated in most normal cells, except in lipogenic tissues such as liver, lactating breast, fetal lung, and adipose tissue. Conversely, several human cancers, including head and neck squamous cell carcinomas (HNSCC), overexpress FASN, which has been associated with poor prognosis and recently suggested as a metabolic oncoprotein. Orlistat is an irreversible inhibitor of FASN ...
46 CitationsSource
The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas
69 CitationsSource
#1Fabiana SeguinH-Index: 4
#2Edgard GranerH-Index: 36
A enzima acido graxo sintase (FASN), cuja expressao e atividade estao elevadas em varias neoplasias malignas humanas, e responsavel pela sintese endogena de acidos graxos saturados de cadeia longa e, consequentemente, pela a producao de fosfolipidios das membranas celulares. A inibicao de FASN com orlistat (Xenical), uma droga anti-obesidade, e descrita como tendo propriedades anti-neoplasicas nos cânceres de prostata, mama, bem como no melanoma. Este composto parece desempenhar tambem um papel ...
#1Fabiana SeguinH-Index: 4
#2Edgard GranerH-Index: 36
A enzima acido graxo sintase (FASN), cuja expressao e atividade estao elevadas em varias neoplasias malignas humanas, e responsavel pela sintese endogena de acidos graxos saturados de cadeia longa e consequentemente para a sintese de fosfolipidios de membrana. A inibicao de FASN por orlistat (Xenical), uma droga anti-obesidade, e descrita como tendo propriedades anti-neoplasicas no câncer de prostata e mama e no melanoma, alem de desempenhar um provavel papel anti-angiogenico, uma vez que tambem...
#1Marco Aurélio Carvalho (State University of Campinas)H-Index: 4
#2Karina G. Zecchin (State University of Campinas)H-Index: 19
Last.Edgard Graner (State University of Campinas)H-Index: 36
view all 12 authors...
Fatty acid synthase (FASN) is the enzyme responsible for the endogenous synthesis of the saturated fatty acid palmitate. In contrast to most normal cells, malignant cells depend on FASN activity for growth and survival. In fact, FASN is overexpressed in a variety of human cancers including cutaneous melanoma, in which its levels of expression are associated with a poor prognosis and depth of invasion. Here, we show that the specific inhibition of FASN activity by the antiobesity drug Orlistat or...
99 CitationsSource
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