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Greg Rubin
Newcastle University
115Publications
21H-index
1,307Citations
Publications 115
Newest
#1Fiona M Walter (University of Cambridge)H-Index: 33
#2Matthew Thompson (UW: University of Washington)H-Index: 43
Last.Greg Rubin (RVI: Royal Victoria Infirmary)H-Index: 21
view all 15 authors...
Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance in real-world, low prevalence populations such as primary care or general community populations. They should therefore be systematically evaluated before implementation to determine whether they lead to earlier detection, are cost-effective, and improve patient safety and quality of care, ...
#1Silvia C Mendonca (University of Cambridge)H-Index: 7
#2Gary A. Abel (University of Exeter)H-Index: 29
Last.Martin Roland (University of Cambridge)H-Index: 67
view all 11 authors...
Cancer Research UK / National Awareness and Early Diagnosis Initiative Project Grant No. C18081/A17854; Cancer Research UK Advanced Clinician Scientist Fellowship No. C18081/A18180
#1Mm Koo (UCL: University College London)H-Index: 3
#2Greg Rubin (Newcastle University)H-Index: 21
Last.Georgios Lyratzopoulos (UCL: University College London)H-Index: 21
view all 4 authors...
Objectives Cancer can be diagnosed in the absence of tumour-related symptoms, but little is known about the frequency and circumstances preceding such diagnoses which occur outside participation in screening programmes. We aimed to examine incidentally diagnosed cancer among a cohort of cancer patients diagnosed in England. Design Cross-sectional study of national primary care audit data on an incident cancer patient population. Setting We analysed free-text information on the presenting feature...
#1Cristina Renzi (UCL: University College London)H-Index: 10
#2A Kaushal (UCL: University College London)H-Index: 2
Last.Niek J. de Wit (UU: Utrecht University)H-Index: 28
view all 11 authors...
An earlier diagnosis is a key strategy for improving the outcomes of patients with cancer. However, achieving this goal can be challenging, particularly for the growing number of people with one or more chronic conditions (comorbidity/multimorbidity) at the time of diagnosis. Pre-existing chronic diseases might affect patient participation in cancer screening, help-seeking for new and/or changing symptoms and clinicians’ decision-making on the use of diagnostic investigations. Evidence suggests,...
#1Elka Humphrys (University of Cambridge)H-Index: 4
#2Jenni Burt (University of Cambridge)H-Index: 11
Last.Fiona M Walter (University of Cambridge)H-Index: 33
view all 5 authors...
#1Domenica Coxon (Edin.: University of Edinburgh)H-Index: 2
#2Christine Campbell (Edin.: University of Edinburgh)H-Index: 21
Last.David Weller (Edin.: University of Edinburgh)H-Index: 52
view all 10 authors...
Background Over recent years there has been a growth in cancer early diagnosis (ED) research, which requires valid measurement of routes to diagnosis and diagnostic intervals. The Aarhus Statement, published in 2012, provided methodological guidance to generate valid data on these key pre-diagnostic measures. However, there is still a wide variety of measuring instruments of varying quality in published research. In this paper we test comprehension of self-completion ED questionnaire items, base...
#1Judith Offman ('KCL': King's College London)H-Index: 6
#2Beth Muldrew (QMUL: Queen Mary University of London)H-Index: 1
Last.Zohrah Khan (QMUL: Queen Mary University of London)H-Index: 1
view all 17 authors...
Background Early detection of oesophageal cancer improves outcomes; however, the optimal strategy for identifying patients at increased risk from the pre-cancerous lesion Barrett’s oesophagus (BE) is not clear. The Cytosponge, a novel non-endoscopic sponge device, combined with the biomarker Trefoil Factor 3 (TFF3) has been tested in four clinical studies. It was found to be safe, accurate and acceptable to patients. The aim of the BEST3 trial is to evaluate if the offer of a Cytosponge-TFF3 tes...
#1Diane J. StevensonH-Index: 3
Last.Christopher J. HawkeyH-Index: 76
view all 10 authors...
Introduction The Helicobacter Eradication Aspirin Trial (HEAT) is a multicentre, double blind, randomised controlled trial investigating whether Helicobacter pylori eradication reduces the incidence of hospitalisation for peptic ulcer bleeding [1]. Participants are subjects aged over 60, taking low dose aspirin for at least four months at the time of recruitment; all participants were recruited from primary care. H. pylori positive participants were randomised to receive one week active trial tr...
#1Mm Koo (UCL: University College London)H-Index: 3
#2Christian von Wagner (UCL: University College London)H-Index: 29
Last.Georgios Lyratzopoulos (UCL: University College London)H-Index: 21
view all 7 authors...
Background: Abdominal symptoms at presentation are common among patients subsequently diagnosed with cancer. While public health education campaigns in England and other countries have traditionally focused on 'red flag' symptoms associated with a single common cancer (e.g., 'blood in poo' and colorectal cancer), there is increasing interest in raising awareness of symptoms grouped by body area or system (eg 'abdominal symptoms'). Evidence regarding the frequency and nature of abdominal symptoms...
#1Mm Koo (UCL: University College London)H-Index: 3
#2Greg Rubin (UCL: University College London)H-Index: 21
Last.Georgios Lyratzopoulos (UCL: University College London)H-Index: 21
view all 3 authors...
Background: Cancer control strategies in different countries increasingly encompass public health education campaigns that aim to promote earlier presentation and diagnosis of cancer by raising awareness of possible cancer symptoms. However, the theoretical understanding that underpins these complex early diagnosis interventions remains underdeveloped. Aim: To propose a theoretical framework to guide the design, implementation, and evaluation of cancer symptom awareness campaigns and motivate fu...
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