Greg Rubin
Royal Victoria Infirmary
CancerPathologyReferralFamily medicineMedicine
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Publications 160
Last. Fiona M WalterH-Index: 34
view all 15 authors...
Evidence has shown for over 20 years that patients residing in rural areas face poorer outcomes for cancer. The inequalities in survival that rural cancer patients face are observed throughout the developed world, yet this issue remains under-examined and unexplained. There is evidence to suggest that rural patients are more likely to be diagnosed as a result of an emergency presentation and that rural patients may take longer to seek help for symptoms. However, research to date has been predomi...
#1Ruth Swann (PHE: Public Health England)H-Index: 2
#2Georgios Lyratzopoulos (UCL: University College London)H-Index: 35
Last. Sean McPhail (PHE: Public Health England)H-Index: 12
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Abstract Background There is a growing emphasis on the speed of diagnosis as an aspect of cancer prognosis. While epidemiological data in the last decade have quantified diagnostic timeliness and its variation, whether and how often prolonged diagnostic intervals can be considered avoidable is unknown. Methods We used data from the English National Cancer Diagnosis Audit (NCDA) on 17,042 patients diagnosed with cancer in 2014. Participating primary care physicians were asked to identify delays i...
2 CitationsSource
#1Elka Humphrys (University of Cambridge)H-Index: 4
#2Fiona M Walter (University of Cambridge)H-Index: 34
Last. Jenni Burt (University of Cambridge)H-Index: 14
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Background Late stage diagnosis of oesophageal and gastric cancer is common, which limits treatment options and contributes to poor survival. Aim To explore patients9 understanding, experience and presentation of symptoms before a diagnosis of oesophageal or gastric cancer. Design & setting Between May 2016 and October 2017, all patients newly diagnosed with oesophageal or gastric cancer were identified at weekly multidisciplinary team meetings at two large hospitals in England. A total of 321 p...
#1M.M. Koo (UCL: University College London)H-Index: 3
#2Ruth Swann (PHE: Public Health England)H-Index: 2
Last. Georgios Lyratzopoulos (UCL: University College London)H-Index: 35
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Summary Background Early diagnosis interventions such as symptom awareness campaigns increasingly form part of global cancer control strategies. However, these strategies will have little impact in improving cancer outcomes if the targeted symptoms represent advanced stage of disease. Therefore, we aimed to examine associations between common presenting symptoms of cancer and stage at diagnosis. Methods In this cross-sectional study, we analysed population-level data from the English National Ca...
7 CitationsSource
#1Clare PearsonH-Index: 6
#1Clare PearsonH-Index: 1
Last. Willie Hamilton (University of Exeter)H-Index: 59
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Introduction Patients presenting to primary care with site-specific alarm symptoms can be referred onto urgent suspected cancer pathways, whereas those with non-specific symptoms currently have no dedicated referral routes leading to delays in cancer diagnosis and poorer outcomes. Pilot Multidisciplinary Diagnostic Centres (MDCs) provide a referral route for such patients in England. Objectives This work aimed to use linked primary care and cancer registration data to describe diagnostic pathway...
#1Silvia C Mendonca (University of Cambridge)H-Index: 7
#2Gary A. Abel (University of Exeter)H-Index: 30
Last. Georgios Lyratzopoulos (University of Cambridge)H-Index: 35
view all 11 authors...
Cancer Research UK / National Awareness and Early Diagnosis Initiative Project Grant No. C18081/A17854; Cancer Research UK Advanced Clinician Scientist Fellowship No. C18081/A18180
1 CitationsSource
#1M.M. Koo (UCL: University College London)H-Index: 3
#2Greg Rubin (Newcastle University)H-Index: 28
Last. Georgios Lyratzopoulos (UCL: University College London)H-Index: 35
view all 4 authors...
Objectives Cancer can be diagnosed in the absence of tumour-related symptoms, but little is known about the frequency and circumstances preceding such diagnoses which occur outside participation in screening programmes. We aimed to examine incidentally diagnosed cancer among a cohort of cancer patients diagnosed in England. Design Cross-sectional study of national primary care audit data on an incident cancer patient population. Setting We analysed free-text information on the presenting feature...
3 CitationsSource
#1Cristina Renzi (UCL: University College London)H-Index: 11
#2A Kaushal (UCL: University College London)H-Index: 3
Last. Georgios Lyratzopoulos (University of Cambridge)H-Index: 35
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An earlier diagnosis is a key strategy for improving the outcomes of patients with cancer. However, achieving this goal can be challenging, particularly for the growing number of people with one or more chronic conditions (comorbidity/multimorbidity) at the time of diagnosis. Pre-existing chronic diseases might affect patient participation in cancer screening, help-seeking for new and/or changing symptoms and clinicians’ decision-making on the use of diagnostic investigations. Evidence suggests,...
5 CitationsSource
#1Fiona M Walter (University of Cambridge)H-Index: 34
#2Matthew Thompson (UW: University of Washington)H-Index: 32
Last. Jon Emery (University of Melbourne)H-Index: 42
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Background Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance in real-world, low prevalence populations such as primary care or general community populations. They should therefore be systematically evaluated before implementation to determine whether they lead to earlier detection, are cost-effective, and improve patient safety and qualit...