Yuko Nawa
Sapporo Medical University
Publications 33
#1Yusuke Yoshikawa (Sapporo Medical University)H-Index: 3
#2Naoyuki Hirata (Sapporo Medical University)H-Index: 4
Last.Michiaki Yamakage (Sapporo Medical University)H-Index: 9
view all 4 authors...
#1Tomohiro Chaki (Sapporo Medical University)H-Index: 2
#2Yuko Nawa (Sapporo Medical University)H-Index: 11
Last.Michiaki Yamakage (Sapporo Medical University)H-Index: 25
view all 6 authors...
Introduction: Cardiopulmonary bypass (CPB) can cause stress response that increases levels of cytokine and catecholamine in plasma, resulting in hyperglycemia. In adults, it has been demonstrated that remifentanil infusion during CPB could prevent increases of cytokine, catecholamine, and blood glucose levels, but such effects of remifentanil in children have not been elucidated. Aim: In this study, we investigated the preventive effects of remifentanil on blood glucose and lactate levels during...
1 CitationsSource
High mobility group box 1 (HMGB1) is tightly connected to the process of tissue organization upon tissue injury. Here we show that HMGB1 controls epithelium and connective tissue regeneration both in vivo and in vitro during palatal wound healing. Heterozygous HMGB1 (Hmgb1+/−) mice and Wild-type (WT) mice were subjected to palatal injury. Maxillary tissues were stained with Mallory Azan or immunostained with anti-HMGB1, anti-proliferating cell nuclear antigen (PCNA), anti-nuclear factor-κB (NF-κ...
4 CitationsSource
#1Xiaojie Meng (Kadai: Kagoshima University)H-Index: 7
#2Salunya Tancharoen (MU: Mahidol University)H-Index: 18
Last.Ikuro Maruyama (Kadai: Kagoshima University)H-Index: 38
view all 7 authors...
1,5-anhydroglucitol (1,5-AG) decreases in diabetic patients and is used as a marker of glycemic control. Type 2 diabetic patients are susceptibile to lipopolysaccharides (LPS), which stimulate macr...
12 CitationsSource
#1Kiyoshi Kikuchi (Kadai: Kagoshima University)H-Index: 15
#2Ko-ichi KawaharaH-Index: 30
Last.Ikuro MaruyamaH-Index: 50
view all 30 authors...
7 CitationsSource
#1Kiyoshi Kikuchi (Kadai: Kagoshima University)H-Index: 15
#2Salunya Tancharoen (MU: Mahidol University)H-Index: 18
Last.Ko-ichi Kawahara (Kadai: Kagoshima University)H-Index: 30
view all 28 authors...
Aquaporin-4 (AQP4) plays a role in the generation of post-ischemic edema. Pharmacological modulation of AQP4 function may thus provide a novel therapeutic strategy for the treatment of stroke, tumor-associated edema, epilepsy, traumatic brain injury, and other disorders of the central nervous system (CNS) associated with altered brain water balance. Edaravone, a free radical scavenger, is used for the treatment of acute ischemic stroke (AIS) in Japan. In this study, edaravone significantly reduc...
50 CitationsSource
#1Yuko Nawa (Kadai: Kagoshima University)H-Index: 11
#2Ko-ichi Kawahara (Kadai: Kagoshima University)H-Index: 30
Last.Ikuro Maruyama (Kadai: Kagoshima University)H-Index: 38
view all 10 authors...
NPM is a major nucleolar multifunctional protein involved in ribosome biogenesis, centrosome duplication, cell-cycle progression, apoptosis, cell differentiation, and sensing cellular stress. Alarmins are endogenous molecules released from activated cells and/or dying cells, which activate the immune system and cause severe damage to cells and tissue organs. In the present work, stimulation of cells with the alarmin-inducible molecule endotoxin, for 16 h, resulted in NPM release into the culture...
24 CitationsSource
#1Xiaojie Meng (Kadai: Kagoshima University)H-Index: 7
#2Ko-ichi Kawahara (Kadai: Kagoshima University)H-Index: 30
Last.Ikuro Maruyama (Kadai: Kagoshima University)H-Index: 38
view all 9 authors...
Abstract 1,5-anhydro- d -fructose (1,5-AF), a monosaccharide formed from starch and glycogen, exhibits antioxidant and antibacterial activity, and inhibits cytokine release by attenuating NF-κB activation in LPS-stimulated mice. The present study examined whether 1,5-AF inhibits lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) in vitro and in vivo . We found that 1,5-AF significantly blocked the production of NO, and protein and mRNA expression of iNOS, and up-regulated IL...
6 CitationsSource