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Jean-Jacques Schott
University of Nantes
164Publications
43H-index
6,919Citations
Publications 165
Newest
#1Thierry Le Tourneau (French Institute of Health and Medical Research)H-Index: 31
#2C Cueff (French Institute of Health and Medical Research)
Last.Jean-Jacques Schott (French Institute of Health and Medical Research)H-Index: 43
view all 8 authors...
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#1Thierry Le Tourneau (French Institute of Health and Medical Research)H-Index: 31
#2C Cueff (French Institute of Health and Medical Research)
Last.Jean-Jacques Schott (French Institute of Health and Medical Research)H-Index: 43
view all 7 authors...
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#1Nadjet Belbachir (Stanford University)H-Index: 1
#2Vincent Portero (University of Nantes)H-Index: 7
Last.Solena Le Scouarnec (University of Nantes)H-Index: 5
view all 33 authors...
AIMS: The Brugada syndrome (BrS) is an inherited cardiac disorder predisposing to ventricular arrhythmias. Despite considerable efforts, its genetic basis and cellular mechanisms remain largely unknown. The objective of this study was to identify a new susceptibility gene for BrS through familial investigation. METHODS AND RESULTS: Whole-exome sequencing performed in a three-generation pedigree with five affected members allowed the identification of one rare non-synonymous substitution (p.R211H...
2 CitationsSource
#1Sébastien Thériault (Laval University)H-Index: 12
#2Christian Dina (University of Nantes)H-Index: 15
Last.Jean-Jacques Schott (University of Nantes)H-Index: 43
view all 31 authors...
Background: Calcific aortic valve stenosis (CAVS) is a frequent and life-threatening cardiovascular disease for which there is currently no medical treatment available. To date, only 2 genes, LPA a...
Source
#1Nicolas Perrot (Laval University)H-Index: 3
#2Sébastien Thériault (Laval University)H-Index: 12
Last.Benoit J. Arsenault (Laval University)H-Index: 30
view all 26 authors...
Importance Genetic variants at theLPAlocus are associated with both calcific aortic valve stenosis (CAVS) and coronary artery disease (CAD). Whether these variants are associated with CAVS in patients with CAD vs those without CAD is unknown. Objective To study the associations ofLPAvariants with CAVS in a cohort of patients undergoing heart surgery andLPAwith CAVS in patients with CAD vs those without CAD and to determine whether first-degree relatives of patients with CAVS and high lipoprotein...
Source
#1Katelynn Toomer (MUSC: Medical University of South Carolina)H-Index: 8
#2Mengyao Yu (Paris V: Paris Descartes University)H-Index: 1
Last.Russell A. Norris (MUSC: Medical University of South Carolina)H-Index: 30
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Mitral valve prolapse (MVP) affects 1 in 40 people and is the most common indication for mitral valve surgery. MVP can cause arrhythmias, heart failure, and sudden cardiac death, and to date, the causes of this disease are poorly understood. We now demonstrate that defects in primary cilia genes and their regulated pathways can cause MVP in familial and sporadic nonsyndromic MVP cases. Our expression studies and genetic ablation experiments confirmed a role for primary cilia in regulating ECM de...
2 CitationsSource
#1Mattia Bosio (UPF: Pompeu Fabra University)H-Index: 5
#2Oliver Drechsel (RKI: Robert Koch Institute)H-Index: 6
Last.Stephan Ossowski (University of Tübingen)H-Index: 34
view all 14 authors...
1 CitationsSource
#1Mengyao Yu (Paris V: Paris Descartes University)H-Index: 1
#2Adrien Georges (Paris V: Paris Descartes University)H-Index: 1
Last.Nabila Bouatia-Naji (Paris V: Paris Descartes University)H-Index: 12
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Background Mitral valve prolapse (MVP) is a common heart valve disease, the most frequent indication for valve repair or replacement. MVP is characterized by excess extracellular matrix secretion a...
Source
#1Lilong Guo (MUSC: Medical University of South Carolina)H-Index: 3
#2Katelynn Toomer (MUSC: Medical University of South Carolina)H-Index: 8
Last.Russell A. Norris (MUSC: Medical University of South Carolina)H-Index: 30
view all 42 authors...
Source
#1Sébastien Thériault (Laval University)H-Index: 12
#2Christian Dina (University of Nantes)H-Index: 15
Last.Jean-Jacques Schott (University of Nantes)H-Index: 43
view all 31 authors...
To date, only two replicated loci, LPA and PALMD , have been identified as causal genes for calcific aortic valve stenosis (CAVS) using genome-wide and transcriptome-wide association study (TWAS). To identify additional susceptibility genes for CAVS, we performed a GWAS meta-analysis totaling 5,115 cases and 354,072 controls of European descent. Four loci achieved genome-wide significance, including two new loci: IL6 (interleukin 6) on 7p15.3 and ALPL (alkaline phosphatase) on 1p36.12. A TWAS in...
1 CitationsSource
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